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Assessment of hindlimb motor recovery affer severe thoracic spinal cord injury in rats: classification of CatWalk XT■ gait analysis parameters

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Neural Regeneration Research 2023年第5期18卷 1084-1089页

作者： Guoli Zheng Hao Zhang Mohamed Tail Hao Wang Johannes Walter Thomas Skutella Andreas Unterberg Klaus Zweckberger Alexander Younsi Department of Neurosurgery University Hospital HeidelbergHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyUniversity of HeidelbergHeidelbergGermany

Assessment of locomotion recovery in preclinical studies of experimental spinal cord injury remains challenging. We studied the CatWalk XT■gait analysis for evaluating hindlimb functional recovery in a widely used and clinically relevant thoracic contusion/compression spinal cord injury model in rats. Rats were randomly assigned to either a T9 spinal cord injury or sham laminectomy. Locomotion recovery was assessed using the Basso, beattie, and Bresnahan open field rating scale and the CatWalk XT■gait analysis. To determine the potential bias from weight changes, corrected hindlimb(H) values(divided by the unaffected forelimb(F) values) were calculated. Six weeks after injury, cyst formation, astrogliosis, and the deposition of chondroitin sulfate glycosaminoglycans were assessed by immunohistochemistry staining. Compared with the baseline, a significant spontaneous recovery could be observed in the CatWalk XT■parameters max intensity, mean intensity, max intensity at%, and max contact mean intensity from 4 weeks after injury onwards. Of note, corrected values(H/F) of CatWalk XT■parameters showed a significantly less vulnerability to the weight changes than absolute values, specifically in static parameters. The corrected CatWalk XT■parameters were positively correlated with the Basso, beattie, and Bresnahan rating scale scores, cyst formation, the immunointensity of astrogliosis and chondroitin sulfate glycosaminoglycan deposition. The CatWalk XT■gait analysis and especially its static parameters, therefore, seem to be highly useful in assessing spontaneous recovery of hindlimb function after severe thoracic spinal cord injury. Because many CatWalk XT■parameters of the hindlimbs seem to be affected by body weight changes, using their corrected values might be a valuable option to improve this dependency.

关键词： Basso beattie and Bresnahan rating scale behavioral assessment CatWalk XT■gait analysis contusive and compressive injury hindlimb motor function histological changes spinal cord injury spontaneous recovery thoracic weight

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芝商所亚太区主管Russell beattie：深化沟通交流助推国际期货市场发展 A05

芝商所亚太区主管Russell Beattie：深化沟通交流助推国际期货...

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中国证券报

作者：李梦扬

“芝商所未来在亚太地区将保持稳健发展。”芝商所董事总经理兼亚太区主管Russell beattie在接受中国证券报记者采访时表示，近期在中国开展为期三周的考察交流，希望与中国期货期权市场各方进行深入交流与探讨，调整其未来在中国市场... 详细信息

“芝商所未来在亚太地区将保持稳健发展。”芝商所董事总经理兼亚太区主管Russell beattie在接受中国证券报记者采访时表示，近期在中国开展为期三周的考察交流，希望与中国期货期权市场各方进行深入交流与探讨，调整其未来在中国市场的发展计划，从而实现芝商所在中国市场长期

关键词：期货经纪公司国际期货 Russell beattie 沟通交流

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Local injection of bone morphogenetic protein 7 promotes neuronal regeneration and motor function recovery after acute spinal cord injury

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Neural Regeneration Research 2018年第6期13卷 1054-1060页

作者： Chen Chen Guang-Chao Bai Hong-Liang Jin Kun Lei Kuan-Xin Li Department of Joint and Spine Xinjiang Production and Construction Corps Hospital Urumqi

After spinal cord injury,the number of glial cells and motor neurons expressing bone morphogenetic protein 7（BMP7）increases,indicating that upregulation of BMP7 can promote nerve repair.We,therefore,tested whether direct injection of BMP7 into acutely injured ratalalo createrywith 50 ng BMP7（BMP7 group）or physiological saline（control group）for 7 consecutive days.Electrophysiological examination showed that the amplitude of N1 in motor evoked potentials（MEP）decreased after spinal cord injury.At 8 weeks post-operation,the amplitude of N1 in the BMP7 group was remarkably higher than that at 1 week post-operation and was higher than that of the control group.Basso,beattie,Bresnahan scale（BBB）scores,hematoxylin-eosin staining,and western blot assay showed that at 1,2,4 and 8 weeks post-operation,BBB scores were increased;Nissl body staining was stronger;the number of Nissl-stained bodies was increased;the number of vacuoles gradually decreased;the number of synapses was increased;and the expression of neuronal marker,neurofilament protein 200,was increased in the hind limbs of the BMP7 group compared with the control group.Western blot assay showed that the expression of GFAP protein in BMP7 group and control group did not change significantly and there was no significant difference between the BMP7 and control groups.These data confirmed that local injection of BMP7 can promote neuronal regeneration after spinal cord injury and promote recovery of motor function in rats.

关键词： nerve regeneration behavior Basso beattie Bresnahan scale score motor evoked potential wave Nissl staining neurons glial cells neurofilament protein 200 glial fibrillary acidic protein neural regeneration

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德凤凰公司收购英beattie公司

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中国橡胶 2000年第21期 36-36页

作者：谢立

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