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The Experimental and Clinical Study on the Effect of Curcumin on Cell Cycle Proteins and Regulating Proteins of Apoptosis in Acute Myelogenous Leukemia

引用

Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第4期22卷 295-298页

作者：陈燕吴裕丹何静陈文娟 InstituteofHematology

To investigate whether the bcl- 2 gene family is involved in m odulating mechanism of apoptosis and change of cell cycle protein induced by curcumin in acute myeloid leukemia HL - 6 0 cell line and primary acute m yelogenous leukem ic cells,the bcl- 2 family member Mcl- 1,Bax and Bak and cell cycle proteins including P2 7kipl,P2 1wafl,cyclin D3and p Rbp- were selected and their ex- pression detected by SABC imm uno- histochem ical stain m *** attitude of sub- G1 peak in DNA histogram was determined by *** TU NEL positive cell percentage was identified by term inal deoxynucleotidyl transferase (Td T ) - m ediated Biotin d U NP end labeling *** was found that when HL - 6 0 cells were treated with 2 5μm ol/ L curcumin for 2 4 h,the expression level of Mcl- 1was down- regulated,but that of Bax and Bak up- regulated time- *** was significant difference in the expression level of Mcl- 1,Bax and Bak between the curcumin- treated groups and control group(Pbcl- 2 gene fam ily indeed participated in the regulatory process of apoptosis induced by curcumin in HL - 6 0 cells and AML *** can induce apoptosis of primary acute myelogenous leukemic cells and disturb cell cycle progression of HL - 6 0 *** m echanism appeared to be m ediated by perturbing G0 / G1 phases checkpoints which associated with up- regulation of P2 7kipl,P2 1wafl and p Rbp- expression,and down- regulation of cyclin D3.

关键词： curcum in bcl- 2 gene family cell cycle protein HL - 6 0 cell prim ary leukemic cell

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