检索结果-南通市图书馆

Therapeutic effect of regulating autophagy in spinal cord injury: a network meta-analysis of direct and indirect comparisons

引用

Neural Regeneration Research 2020年第6期15卷 1120-1132页

作者： Duo Zhang Di Zhu Fang Wang Ji-Chao Zhu Xu Zhai Yuan Yuan Chen-Xi Li Department of Orthopedics Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Orthopedics Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Emergency Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Spinal Cord Injury Rehabilitation China Rehabilitation Research CenterBeijingChina

Objective:An increasing number of studies indicate that autophagy plays an important role in the pathogenesis of spinal cord injury,and that regulating autophagy can enhance recovery from spinal cord ***,the effect of regulating autophagy and whether autophagy is detrimental or beneficial after spinal cord injury remain ***,in this study we evaluated the effects of autophagy regulation on spinal cord injury in rats by direct and indirect comparison,in an effort to provide a basis for further *** source:Relevant literature published from inception to February 1,2018 were included by searching Wanfang,CNKI,Web of Science,MEDLINE(OvidSP),PubMed and Google Scholar in English and *** keywords included"autophagy","spinal cord injury",and"rat".Data selection:The literature included in vivo experimental studies on autophagy regulation in the treatment of spinal cord injury(including intervention pre-and post-spinal cord injury).Meta-analyses were conducted at different time points to compare the therapeutic effects of promoting or inhibiting autophagy,and subgroup analyses were also *** measure:basso,beattie,and Bresnahan ***:Of the 622 studies,33 studies of median quality were included in the ***,beattie,and Bresnahan scores were higher at 1 day(MD=1.80,95%CI:0.81-2.79,P=0.0004),3 days(MD=0.92,95%CI:0.72-1.13,Pand 4 weeks(MD=3.18,95%CI:2.43-3.92,Pbasso,beattie,and Bresnahan scores were higher at 1 day(MD=6.48,95%CI:5.83-7.13,Pand 4 weeks(MD=4.41,95%CI:1.08-7.75,P=0.01)after spinal cord injury with downregulation of autophagy compared w

关键词： autophagy basso,beattie,and Bresnahan scores indirect comparison meta-analysis nerve regeneration neural regeneration neurological function rat models regulation spinal cord injury strategy analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of neural stem cell transplantation on the motor function of rats with contusion spinal cord injuries:a meta-analysis

引用

Neural Regeneration Research 2020年第4期15卷 748-758页

作者： Kai Qian Tuo-Ye Xu Xi Wang Tao Ma Kai-Xin Zhang Kun Yang Teng-Da Qian Jing Shi Li-Xin Li Zheng Wang Department of Neurosurgery the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Intensive Care Unit the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurosurgery the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu ProvinceChina Department of Neurosurgery Huangshan City People’s HospitalHuangshanAnhui ProvinceChina Department of Neurosurgery Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurosurgery Jintan Hospital Affiliated to Jiangsu UniversityJintanJiangsu ProvinceChina Department of Gerontology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Objective:To judge the efficacies of neural stem cell(NSC)transplantation on functional recovery following contusion spinal cord injuries(SCIs).Data sources:Studies in which NSCs were transplanted into a clinically relevant,standardized rat model of contusion SCI were identified by searching the PubMed,Embase and Cochrane databases,and the extracted data were analyzed by Stata *** selection:Inclusion criteria were that NSCs were used in in vivo animal studies to treat contusion SCIs and that behavioral assessment of locomotor functional recovery was performed using the basso,beattie,and Bresnahan lo-comotor rating *** criteria included a follow-up of less than 4 weeks and the lack of control *** measures:The restoration of motor function was assessed by the basso,beattie,and Bresnahan locomotor rating ***:We identified 1756 non-duplicated papers by searching the aforementioned electronic databases,and 30 full-text articles met the inclusion criteria.A total of 37 studies reported in the 30 articles were included in the *** meta-analysis results showed that transplanted NSCs could improve the motor function recovery of rats following contusion SCIs,to a moderate extent(pooled standardized mean difference(SMD)=0.73;95%confidence interval(CI):0.47–1.00;Pand from different origins(brain-derived:SMD=0.59;95%CI:0.27–0.91;spinal cord-derived:SMD=0.51;95%CI:0.22–0.79)had similar efficacies on improved functional recovery;however,adult induced pluripotent stem cell-derived NSCs showed no significant ***,the use of higher doses of transplanted NSCs or the administration of immunosuppressive agents did not promote better locomotor function recovery(SMD=0.45;95%CI:0.21–0.70).However,shorter periods between the co

关键词： basso,beattie,and Bresnahan locomotor rating scale cell transplantation meta-analysis motor functional recovery neural regeneration neural stem cell neural stem cell transplantation rat model spinal contusion spinal cord injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Serum and cerebrospinal fluid tau protein level as biomarkers for evaluating acute spinal cord injury severity and motor function outcome

引用

Neural Regeneration Research 2019年第5期14卷 896-902页

作者： Ying Tang Hong-Liang Liu Ling-Xia Min Hao-Shi Yuan Lei Guo Peng-Bo Han Yu-Xin Lu Jian-Feng Zhong Dong-Lin Wang Key Laboratory of Biorheological Science and Technology Ministry of Education (Chongqing University) Chongqing University Cancer Hospital Department of Rehabilitation Southwest Hospital Third Military Medical University Department of Spine Surgery Second Affiliated Hospital of Xi'an Medical University Department of Orthopedics Chinese PLA Beijing Army General Hospital

Tau protein, a microtubule-associated protein, has a high specific expression in neurons and axons. Because traumatic spinal cord injury mainly affects neurons and axons, we speculated that tau protein may be a promising biomarker to reflect the degree of spinal cord injury and prognosis of motor function. In this study, 160 female Sprague-Dawley rats were randomly divided into a sham group, and mild, moderate, and severe spinal cord injury groups. A laminectomy was performed at the T8 level to expose the spinal cord in all groups. A contusion lesion was made with the NYU-MASCIS impactor by dropping a 10 g rod from heights of 12.5 mm(mild), 25 mm(moderate) and 50 mm(severe) upon the exposed dorsal surface of the spinal cord. Tau protein levels were measured in serum and cerebrospinal fluid samples at 1, 6, 12, 24 hours, 3, 7, 14 and 28 days after operation. Locomotor function of all rats was assessed using the basso, beattie and Bresnahan locomotor rating scale. Tau protein concentration in the three spinal cord injury groups(both in serum and cerebrospinal fluid) rapidly increased and peaked at 12 hours after spinal cord injury. Statistically significant positive linear correlations were found between tau protein level and spinal cord injury severity in the three spinal cord injury groups, and between the tau protein level and basso, beattie, and Bresnahan locomotor rating scale scores. The tau protein level at 12 hours in the three spinal cord injury groups was negatively correlated with basso, beattie, and Bresnahan locomotor rating scale scores at 28 days(serum: r =-0.94; cerebrospinal fluid: r =-0.95). Our data suggest that tau protein levels in serum and cerebrospinal fluid might be a promising biomarker for predicting the severity and functional outcome of traumatic spinal cord injury.

关键词： nerve regeneration spinal cord injury tau injury severity outcome cerebrospinal fluid serum biomarker basso,beattie,and Bresnahan locomotor rating scale neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：