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HIV-1 tropism

Protein & Cell 2010年第6期1卷 510-513页

作者： Aikichi Iwamoto Noriaki Hosoya Ai Kawana-Tachikawa Division of Infectious Diseases Advanced Clinical Research CenterInstitute of Medical ScienceThe University of TokyoTokyo 108-8639Japan International Research Center for Infectious Diseases Institute of Medical ScienceThe University of TokyoTokyo 108-8639Japan Research Center for Asian Infectious Diseases Institute of Medical ScienceThe University of TokyoTokyo 108-8639Japan

Acquired immunodeficiency syndrome(AIDS)was reported in 1981((CDC),1981).Human immunodeficiency virus type-1(HIV-1),the virus causing AIDS,was isolated in 1983(barré-Sinoussi et al.,1983).Since AIDS patients were characterized by a profound decrease in CD4-positive T cell count(Gottlieb et al.,1981),it was a logical consequence that CD4 would be the most probable receptor for the virus.Actually,it was confirmed that CD4 is the primary receptor for HIV-1 in 1986(Maddon et al.,1986).However,it was speculated that HIV-1 requires another factor to infect a cell,since CD4 alone could not support HIV-1 infection to nonhuman cells(Weiner et al.,1991).

关键词： immunodeficiency barr AIDS

In situ detection of Epsteinbarr virus in gastric carcinoma tissuein China highrisk area

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World Journal of Gastroenterology 1999年第6期5卷 531-532页

作者： WAN Rong, GAO Mei Qin, GAO Ling Yun, CHEN Bi Feng and CAI Qian Kun 福建医科大学福建福州 350004 福建医科大学福建福州

INTRODUCTIONEpstein-barr virus (EBV), a gammaherpesvirus, has been strongly associated with African Burkitt's lymphoma and nasopharyngeal carcinoma. Recently it has been identified in lymphoepithelioma-like carcinoma of thymus, tonsil, lung and in some gastric carcinoma[1-4]. The development of very sensitive methods for detection of EBV infection in archival pathologic tumor sections has allowed us to study the association of EBV with gastric adenocarcinomas by using in situ hybridization with EBER-1 oligoprobes and immunohistochemistry with anti-LMP1 antibodies.

关键词： stomach neoplasms Epstein barr virus in situ hybridization LMP 1 protein

Association between Guillain-barré syndrome and hepatitis E infection: A data-driven ecological study in Hong Kong

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Asian Pacific Journal of Tropical Medicine 2021年第1期14卷 47-48页

作者： Xue Liang Shi Zhao Department of Hematology The 989th Hospital of the Joint Logistics Support Force of Chinese PLALuoyang471031China JC School of Public Health and Primary Care Chinese University of Hong KongHong Kong SARChina Shenzhen Research Institute of Chinese University of Hong Kong ShenzhenChina

Guillain-barrésyndrome(GBS)is an uncommon neurological disorder that may cause damage to the peripheral nerves[1].The triggering of GBS is commonly caused by Campylobacter jejuni and other bacterial and viral infections.Hepatitis infections as the triggering factors including hepatitis A,B,C,E viruses are being increasingly recognized[2,3].Among all hepatitis,hepatitis E virus(HEV)is more likely to be under-diagnosed,most being subclinical infections.In developed countries,extra-hepatic manifestations as well as clinical disorders may occur[2].

关键词： barr hepatitis Guillain

Epstein barr virus-positive mucocutaneous ulcer of thecolon associated Hodgkin lymphoma in Crohn＇s disease

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World Journal of Gastroenterology 2015年第19期21卷 6072-6076页

作者： Neil R Moran Bradley Webster Kenneth M Lee Judith Trotman YiuLam Kwan John Napoli Rupert W Leong Neil R Moran Rupert gW Leong Gastroenterology and Liver Services Concord Repatriation General Hospital Sydney NSW 2137 Australia.

Epstein barr virus （EBV） positive mucocutaneous ulcers（EBVMCU） form part of a spectrum of EBV-associatedlymphoproliferative disease. They have been reportedin the setting of immunosenescence and iatrogenicimmunosuppression, affecting the oropharyngeal mucosa,skin and gastrointestinal tract （GIT）. Case reports andseries to date suggest a benign natural history respondingto conservative management, particularly in the GIT. Wereport an unusual case of EBVMCU in the colon, arisingin the setting of immunosuppression in the treatment ofCrohn＇s disease, with progression to Hodgkin lymphoma18 mo after cessation of infliximab. The patient presentedwith multiple areas of segmental colonic ulceration,histologically showing a polymorphous infiltrate withEBV positive Reed-Sternberg-like cells. A diagnosisof EBVMCU was made. The ulcers failed to regressupon cessation of infliximab and methotrexate for 18mo. Following commencement of prednisolone for herCrohn＇s disease, the patient developed widespreadHodgkin lymphoma which ultimately presented as alife-threatening lower GIT bleed requiring emergencycolectomy. This is the first report of progression ofEBVMCU to Hodgkin lymphoma, in the setting of ongoingiatrogenic immunosuppression and inflammatory boweldisease.

关键词： Epstein barr virus Mucocutaneous ulcer Hodgkin lymphoma Inflammatory bowel disease Crohn's disease

EB病毒阳性T／NK细胞淋巴组织增殖性疾病的研究进展

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中华病理学杂志 2011年第4期40卷 285-288页

作者：郑晓丹金妍周小鸽首都医科大学附属北京友谊医院病理科 100050

Epstein—barr病毒（EBV）属于疱疹病毒1亚科，1964年由Epstein和barr首次在Burkitt淋巴瘤细胞株中发现。EBV通过唾液传播，正常人群中感染率在90％以上，感染后终生携带EBV。EBV与多种疾病有关，有的仅有轻微症状，如同普通感冒；

关键词：淋巴组织增殖性疾病 EB病毒 T/NK细胞 t淋巴瘤细胞株阳性 barr EBV 疱疹病毒

Posttransplant lymphoproliferative disorders following liver transplantation: where are we now?

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World Journal of Gastroenterology 2015年第39期21卷 11034-11043页

作者： Daan Dierickx Nina Cardinaels Department of Hematology University Hospitals Leuven

Liver transplantation has emerged as a life-saving treatment for several patients with acute liver failure, end stage liver disease and primary hepatic malignancies. However, long term immunosuppressive therapy aiming to reduce the risk of transplant rejection increases the incidence of several com-plications including malignancies. This is illustrated by the observation of a high ratio between observed and expected cases of lymphoproliferative disorders following liver transplantation. Despite a huge heterogeneity in morphological appearance of these disorders ranging from reactive-like lesions to real lymphomas, they are collectively termed posttransplant lymphoproliferative disorders. In this review we will provide an overview of this rare but challenging disorder as a complication of liver transplantation.

关键词： Epstein barr virus Liver transplantation Posttrans

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EB病毒相关疾病免疫治疗的研究进展

中华儿科杂志 2016年第8期54卷 628-631页

作者：向征涂文伟香港大学医学院儿童及青少年医学系 999077

EB病毒（Epstein—barr virus，EBV）是属于人疱疹病毒1亚科的DNA病毒，可侵袭宿主的B淋巴细胞以及T细胞和NK细胞。EBV感染在全球范围内普遍存在，约90％以上的成年人EBV抗体检测呈阳性，其主要通过唾液传播，也可经输血传染。

关键词： EB病毒相关疾病免疫治疗 EBV感染 DNA病毒人疱疹病毒 B淋巴细胞 barr NK细胞

Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein barr virus encoded latent membrane protein 1

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Science China(Life Sciences) 2005年第1期48卷 70-80页

作者： Leo M.Lee Laboratory of Molecular Technology SAIC-Frederick

Epstein-barr virus (EBV) encoded latent membrane protein 1 (LMP1) may trigger the transcription factor AP-1 including c-Jun and c-fos. In this report, using a Tet-on LMP1 HNE2 cell line which is a dual-stable LMP1 integrated nasopharyngeal carcinoma (NPC) cell line and the expression of LMP1 in which could be regulated by the Tet-on system, we show that Jun B can efficiently form a new heterodimeric complex with the c-Jun protein under the regulation of LMP1, phosphorylation of c-Jun (ser 63, ser 73) and Jun B is involved in the process of the new heterodimeric formation. We also find that this heterodimeric form can bind to the AP-1 consensus sequence. Transfection studies suggest that JNK interaction protein (JIP) could inhibit the heterodimer formation of c-Jun and Jun B through blocking the AP-1 signaling pathway triggered by LMP1. The interaction and function between c-Jun protein and Jun B protein increase the repertoire of possible regulatory complexes by LMP1 that could play an important role in the regulation of transcription of specific cellular genes in the process of genesis of nasopharyngeal carcinoma.

关键词： Epstein barr virus, latent membrane protein 1, Jun B, c-Jun, heterodimer, DNA binding, JNK, JIP.

Rare presentation of post-transplant lymphoproliferative disorder isolated to gastroesophageal junction

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World Journal of Gastrointestinal Oncology 2013年第12期5卷 230-234页

作者： Brad M Haverkos Veeral M Oza Andrea Johnson Jon Walker Arwa Shana'ah Department of Medicine Division of He-matology and Medical Oncology Ohio State University Wexner Medical Center Department of Medicine Division of Gastroenterology Hepatology and Nutrition Ohio State University Wexner Medical Center Department of Medicine Division of Internal Medicine Ohio State University Wexner Medical Center Department of Medicine Division of Gastroenterology Hepatology and Nutrition Ohio State Uni- versity Wexner Medical Center Department of Pathology Ohio State University Wexner Medical Center

Post transplant lymphoproliferative disorder (PTLD) represents a life threatening disorder occurring after transplantation, ranging from a polyclonal mononucleo- sis like illness to a monomorphic high grade neoplasm with cytologic and histopathologic evidence indica- tive of transformation to lymphoma. PTLD of diffuse large B-cell lymphoma (DLBCL) subtype, isolated to the esophagus is a rare diagnosis. We describe the first case of an immunocompromised adult patient diagnosed with DLBCL-PTLD limited to his esophagus without an associated mass or locoregional lymphade-nopathy on imaging since the institution of the revised Cheson criteria, which includes positron emission tomography-computed tomography as the standard staging modality. Even more unique to our case was the suggestion of underlying cytomegalovirus (CMV) gastritis leading to a hypothesis about a less well understood relationship between CMV and Epstein barr virus (EBV). In the post transplant setting, im- munocompromised state, or EBV positive state, upper gastrointestinal symptoms should prompt investigation with an upper endoscopy (EGD). Additionally, specific to our case, the fact that the patients' presentation was suspicious for CMV gastritis raises the possibility that the CMV infection predated his PTLD increasing his risk of acquiring PTLD. This reemphasizes the im- portance and diagnostic utility of early screening with EGD in patients after transplantation.

关键词： B-cell lymphoma Esophageal Lymphopro-liferative Post-transplant Epstein barr virus