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中华器官移植杂志 2018年第9期39卷 565-570页

作者：黄亚冰郭晖钟伟雄武汉大学人民医院病理科 430060 华中科技大学同济医学院附属同济医院器官移植研究所武汉430033 威斯康星大学医学与公共卫生学院病理与检验医学系美国53705

第十四届Banff移植病理学会议暨加泰罗尼亚移植年会于2017年3月27-31日在西班牙的巴塞罗那举行。来自23个国家的共计479名病理学家、免疫学家、移植外科及内科医生和遗传免疫学专家参加了此次会议。

关键词：移植外科 Banff 病理学诊断分类会议肾病理修订遗传免疫学

Banff-2017移植肾病理分类方案修订解读

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实用器官移植电子杂志 2019年第5期7卷 352-355页

作者：吴珊于金宇傅耀文吉林大学第一医院泌尿外科二科吉林长春130021 吉林大学基础医学院病理学系吉林长春130021

第14 届移植病理Banff会议2017年3月27-31日在西班牙巴塞罗那举行,来自23个国家的479名专家参会,会议内容发表于2018年1月美国移植杂志(Am J Transplant)[1]。本次会议:①对肾移植排斥病理诊断有新修订;②继续按2015年Banff会议规划探... 详细信息

第14 届移植病理Banff会议2017年3月27-31日在西班牙巴塞罗那举行,来自23个国家的479名专家参会,会议内容发表于2018年1月美国移植杂志(Am J Transplant)[1]。本次会议:①对肾移植排斥病理诊断有新修订;②继续按2015年Banff会议规划探讨有可能纳入Banff分类方案的“分子诊断”[2],包括在抗体介导排斥反应的诊断中,潜在“抗供体特异性抗体(donorspecific antibody,DSA)”的替代分子及其分子特性;③正式会议前一天的会前会,主要讨论新一代临床试验的终点或替代终点的界定;④本次会议照例有不同的Banff 工作组(BWG)继续有计划的进行有针对性研究。

关键词：移植排斥分类方案肾病理修订 Banff 解读病理诊断分子诊断

供肾移植术前活检的Banff组织病理学诊断共识解读

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实用器官移植电子杂志 2017年第6期5卷 401-404页

作者：郭晖陈实华中科技大学同济医学院附属医院器官移植研究所器官移植教育部重点实验室/卫生部器官移植重点实验室湖北武汉430030

1背景与意义随着全球范围内供者器官的严重短缺,尤其是此背景下越来越多边缘性供者器官的应用,供肾质量及其对移植术后存活的影响日益受到关注。对供肾的质量需要进行综合评估,在供者临床信息评估和机械灌注参数评估的基础上,

关键词：供肾移植组织病理学诊断 Banff 术前活检解读参数评估供肾质量移植术后

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2015年Banff会议肾移植报告解读

实用器官移植电子杂志 2017年第2期5卷 88-105页

作者：王政禄天津市第一中心医院病理科天津300192

第十三届Banff会议在加拿大温哥华举行,来自28个国家的共计451名病理学家、免疫学家、临床及外科专家参加本次会议。会议首先回顾分析了2013年修改的抗体介导性排斥（antibodymediated rejection,ABMR）诊断标准对临床的影响,随后,

关键词： Banff rejection tubular graft arteritis 性排斥 inflammation cortical 抗体介导 glomerular

移植肾慢性排斥反应的Banff评分及其发病机制

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解放军医学杂志 1999年第1期24卷 60-61页

作者：赵海潞李红芬陈光富游联璧李炎唐肖序仁解放军总医院

１９９３年的ＢＡＮＦＦ分类系统为移植肾病理提供了统一的形态学标准，为移植肾的管理提供了可靠的保证〔１～３〕。病理学上，慢性排斥反应缺乏特异的形态学标准，其发生机制也不清楚〔４〕。为此，本研究评价了移植肾慢性排斥反应Ｂ... 详细信息

１９９３年的ＢＡＮＦＦ分类系统为移植肾病理提供了统一的形态学标准，为移植肾的管理提供了可靠的保证〔１～３〕。病理学上，慢性排斥反应缺乏特异的形态学标准，其发生机制也不清楚〔４〕。为此，本研究评价了移植肾慢性排斥反应ＢＡＮＦＦ分级的准确性，确立移植肾慢...

关键词：肾移植免疫排斥反应 Banff

Abundance and Diversity of the Phototrophic Microbial Mat Communities of Sulphur Mountain Banff Springs and Their Significance to the Endangered Snail, <i>Physella johnsoni</i>

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Open Journal of Ecology 2014年第8期4卷 488-516页

作者： Michael Bilyj Dwayne Lepitzki Elizabeth Hughes Jolantha Swiderski Erko Stackebrandt Charlie Pacas Vladimir V. Yurkov Banff National Park Office Banff Canada Department of Microbiology University of Manitoba Winnipeg Canada DSMZ—Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH Braunschweig Germany

Seasonal population fluctuations and diversity of anoxygenic phototrophs and cyanobacteria at the Sulphur Mountain thermal springs, Banff, Canada were investigated and compared to drastic population changes of the endangered snail Physella johnsoni. The microbial community revealed new species of anoxygenic phototrophic bacteria with novel spectral and morphological characteristics. Major mat-forming organisms included densely growing Thiothrix-like species, oxygenic phototrophs of the genera Spirulina, Oscillatoria, and Phormidium and purple nonsulfur bacteria Rhodobacter, Rhodopseudomonas and Rhodomicrobium. Aerobic anoxygenic phototrophs comprised a significant portion, upwards of 9.6 × 104 CFU/cm2 of mat or 18.9% of total aerobic heterotrophic isolates, while PNSB and purple sulfur bacteria were quantified at maximum abundance of 3.2 × 105 and 2.0 × 106 CFU/cm2 of mat, respectively. Photosynthetic activity revealed incredibly productive carbon fixation rates, averaging 40.5 mg C/cm2/day at one studied spring system. A temporal mismatch was observed for mat area and available organics to the fluctuation of P. johnsoni population in a tracking inertia manner. Mat chlorophyll a content appeared directly proportional to snail numbers making it an appropriate indicator of population. This survey of the Sulphur springs microbial communities suggests that phototrophic species are among the main determinants to the proliferation of P. johnsoni.

关键词： Physella johnsoni Cyanobacterial Mats Thermal Springs Banff Canada Phototrophic Bacteria

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肾移植病理分类─—Banff分类方案

透析与人工器官 1994年第3期5卷 42-46页

作者：陈惠萍黎磊石金陵医院解放军肾脏病研究所

肾移植病理分类─—ＢＡＮＦＦ分类方案金陵医院解放军肾脏病研究所陈惠萍，黎磊石１９９１年８月２—４日，来自美国、法国、英国、和日本等国的肾脏病理、临床和外科器官移植专家，聚集在加拿大ＢＡＮＦＦ城，共同拟定了国际标准的肾... 详细信息

肾移植病理分类─—ＢＡＮＦＦ分类方案金陵医院解放军肾脏病研究所陈惠萍，黎磊石１９９１年８月２—４日，来自美国、法国、英国、和日本等国的肾脏病理、临床和外科器官移植专家，聚集在加拿大ＢＡＮＦＦ城，共同拟定了国际标准的肾移植病理分类方案（以下简称“方案”...

关键词： Banff 病理分类动脉内膜炎器官移植急性排异反应肾脏病理黎磊石超急性排异供肾活检小管

Biomarkers and a tailored approach for immune monitoring in kidney transplantation

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World Journal of Transplantation 2017年第6期7卷 276-284页

作者： Francisco Salcido-Ochoa John Carson Allen Jr Tregs and HLA Research Force Francisco Kidney and Medical CentreMount Elizabeth Novena Hospital Centre for Quantitative Medicine Duke-NUS Graduate Medical School

A literature review on immune monitoring in kidney transplantation produced dozens of research articles and a multitude of promising biomarkers,all in the quest for the much sought after-but perennially elusive-"holy grail" of kidney biomarkers able to unequivocally predict acute transplant rejection vs non-rejection.Detection methodologies and study designs were many and varied.Hence the motivation for this editorial,which espouses the notion that in today's kidney transplantation milieu,the judicious use of disease classifiers tailored to specific patient immune risks may be more achievable and productive in the long run and confer a greater advantage for patient treatment than the pursuit of a single "omniscient" biomarker.In addition,we desire to direct attention toward greater scrutiny of biomarker publications and decisions to implement biomarkers in practice,standardization of methods in the development of biomarkers and consideration for adoption of "biomarker-driven" biopsies.We propose "biomarkerdriven" biopsies as an adjunctive to and/or alternative to random surveillance(protocol) biopsies or belated indication biopsies.The discovery of a single kidney transplantation biomarker would represent a major breakthrough in kidney transplantation practice,but until that occurs-if ever it does occur,other approaches offer substantial potential for unlocking prognostic,diagnostic and therapeutic options.We conclude our editorial with suggestions and recommendations for productively incorporating current biomarkers into diagnostic algorithms and for testing future biomarkers of acute rejection in kidney transplantation.

关键词： Acute rejection Banff classification Biomarker Human leukocyte antigen matching Immune monitoring Immunological risk Kidney transplantation Protocol biopsy

Histopathological analysis of infiltrating T cell subsets in acute T cell-mediated rejection in the kidney transplant

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World Journal of Transplantation 2017年第4期7卷 222-234页

作者： Francisco Salcido-Ochoa Susan Swee-Shan Hue Siyu Peng Zhaoxiang Fan Reiko Lixiang Li Jabed Iqbal John Carson Allen Jr Alwin Hwai Liang Loh Tregs and HLA Research Force and Renal Medicine Department Singapore General Hospital Tregs and HLA Research Force and Department of Pathology National University Hospital Tregs and HLA Research Force and Yong Loo Lin School of Medicine National University of Singapore Department of Pathology and Laboratory Medicine KK Women’s and Children’s Hospital Department of Pathology Singapore General Hospital Centre for Quantitative Medicine Duke-NUS Graduate Medical School

AIM To compare the differential immune T cell subset com-position in patients with acute T cell-mediated rejection in the kidney transplant with subset composition in the absence of rejection, and to explore the association of their respective immune profiles with kidney transplant outcomes.METHODS A pilot cross-sectional histopathological analysis of the immune infiltrate was performed using immunohistochemistry in a cohort of 14 patients with acute T cellmediated rejection in the kidney transplant and 7 kidney transplant patients with no rejection subjected to biopsy to investigate acute kidney transplant dysfunction. All patients were recruited consecutively from 2012 to 2014 at the Singapore General Hospital. Association of the immune infiltrates with kidney transplant outcomes at up to 54 mo of follow up was also explored prospectively.RESULTS In a comparison to the absence of rejection, acute T cell-mediated rejection in the kidney transplant was characterised by numerical dominance of cytotoxic T lymphocytes over Foxp3^+ regulatory T cells, but did not reach statistical significance owing to the small sample size in our pilot study. There was no obvious difference in absolute numbers of infiltrating cytotoxic T lymphocytes, Foxp3^+ regulatory T cells and Th17 cells between the two patient groups when quantified separately. Our exploratory analysis on associations of T cell subset quantifications with kidney transplant outcomes revealed that the degree of Th17 cell infiltration was significantly associated with shorter time to doubling of creatinine and shorter time to transplant loss.CONCLUSION Although this was a small pilot study, results support our suspicion that in kidney transplant patients the immune balance in acute T cell-mediated rejection is tilted towards the pro-rejection forces and prompt larger and more sophisticated studies.

关键词： Acute T cell-mediated rejection in the kidney transplant Banff classification Cytotoxic T cell Regulatory T cell Th17 cell

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慢性移植物肾病的诊断和防治进展

中华肾脏病杂志 2008年第5期24卷 363-367页

作者：陆福明复旦大学附属华山医院肾脏科上海200040

慢性排异反应最早被普遍认为是晚期移植肾丧失功能的主要原因，随着移植学研究的不断深入，人们进一步认识到移植肾丧失功能包含了免疫和非免疫因素，提出了“慢性移植物肾病（chronic allograft nephropathy，CAN）”这个概念，为治疗... 详细信息

慢性排异反应最早被普遍认为是晚期移植肾丧失功能的主要原因，随着移植学研究的不断深入，人们进一步认识到移植肾丧失功能包含了免疫和非免疫因素，提出了“慢性移植物肾病（chronic allograft nephropathy，CAN）”这个概念，为治疗提供了理论依据。虽然最新的Banff会议取消“CAN”一词，提出“慢性移植物损伤（chronic allograft injury）和慢性抗体介导的排异反应（chronic antibody mediated rejection）”的概念，

关键词：慢性移植物肾病慢性排异反应非免疫因素防治诊断 Banff 移植物损伤抗体介导