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Discrimination of TCM constitutions by biochemical and routine urine indexes

Journal of Traditional Chinese Medical Sciences 2022年第2期9卷 153-159页

作者： Xiaoling Liu Pengfei Zhao Jianhua Zhen Shen Zhang Hesong Wang Yuxiu Sun Wei Wang Tingjian Wang Kaiwen Hu Guangrui Huang School of Life Sciences Beijing University of Chinese MedicineBeijing102488China Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China Beijing Research Institute of Chinese Medicine Beijing University of Chinese MedicineBeijing100029China Department of Cancer Biology Dana-Farber Cancer InstituteBostonMA02215USA

Objective:To investigate whether the specific traditional Chinese medicine(TCM)constitution of individuals can be defined by certain biological indexes instead of answering the questionnaire,and to explore the possibility of discriminating nine TCM constitutions from each other simultaneously using biological ***:Blood and urine samples from 152 individuals with nine TCM constitutions were collected,and the related biological indexes were analyzed combining ANOVA,multiple comparison,discriminant analysis,and support vector ***:We found that 4 out of 24 blood routine indexes,7 out of 10 urine routine indexes,and 12 out of 32 biochemical indexes showed differences among the ***-sensitivity C-reactive protein,apolipoprotein A1,and alkaline phosphatase were potential candidates for screening out individuals with unbalanced *** uric acid,high-density lipoprotein,apolipoprotein A1,creatine kinase,total protein,aspartate aminotransferase,total bile acid,dehydrogenase,sodium,and calcium levels had the potential to directly distinguish the nine TCM constitutions from each *** these indexes,the highest ratio of discriminant analysis between two constitutions was 95.5%,while the lowest was 66.1%.Conclusion:Our results suggest that some biochemical and urine indexes are related to various TCM constitutions,and thus they have the potential to be used for TCM constitution classification.

关键词： Traditional Chinese medicine constitution classification balance constitution Unbalanced constitutions Biochemical indexes Routine urine indexes Linear discriminant analysis

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