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Acute Toxicity and bactericidal property of Tetrakis Hydroxymethyl Phosphonium Sulfate in Japanese Eel

Animal Husbandry and Feed Science 2010年第10期2卷 19-21页

作者： LIN Ming-hui LIU Chun-hua CHEN Dao-yin HUANG Zhi-bin SUN Bao-xing Pearl River Fisheries Research Institute of Chinese Academy of Fishery Sciences Guangzhou 510280 China Liantang Fish Disease Control Institute of Nanchang County Nanchang 330200 China Guangzhou Changyang Green Veterinary Drugs Co. Ltd. Guangzhou 511450 China

[ Objective] To understand the toxicity and sterilization effects of the tetrakis hydroxmethyl phosphonium sulfate （THPS） as a novel quatemary phosphonium biocide. [ Method] Under hydrostatic conditions, the acute toxicity and bactericidal property of THPS on the Fiexibacter coiumnaris （ F. columnaris） were observed in Japanese eel. The semi-lethal concentration （LCso）, safe concentration （Sc）, minimum inhibitory concentration （MIC）, minimum bactericidal concentration （MBC） and the sterilization rate of THPS were calculated, respectively. [ Result ] The LCso of THPS at 24, 48 and 96 h were 11.9, 9.9 and 9.1 mg/L, respectively. The Sc of THPS at 24 h was 2.1 mg/L; the MIC and MBC of THPS to the F. columnaris were 0.36 and 0.72 mg/L; and the sterilization rate was 100% at a concentration of 0.7 mg/L at 12 h. The sterilization rate of THPS had no great change with pH values varying from 5.5 to 9.5. [ Condusion] The THPS is a novel, safe and effective biocide for prevention and treatment of bacterial diseases of Japanese eel.

关键词： T etrakis hydroxmethyl phosphonium sulfate Japanese eel （Anguil/a japonica） Fiexibacter coiumnads Toxicity bactericidal property

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Dual-function antibacterial surfaces to resist and kill bacteria:Painting a picture with two brushes simultaneously

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Journal of Materials Science & Technology 2021年第11期70卷 24-38页

作者： Yi Zou Yanxia Zhang Qian Yu Hong Chen Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital Soochow UniversitySuzhou 215007China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Attachment of bacteria and subsequent formation of biofilms on material surfaces lead to serious consequences including infection,contamination and biofouling,posing a prominent threat to human health and causing problems in many industries.Therefore,it is highly desirable to endow the surfaces with antibacterial properties.Traditional antibacterial surfaces are designed via either bacteria-resisting strategy to prevent the initial adhesion of bacteria or bacteria-killing strategy to eradicate any bacteria that attach to the surface.However,these single-function surfaces have their inherent shortcomings and cannot realize long-term efficacy against bacteria.In recent years,various dual-function antibacterial surfaces with both bacteria-resisting and bacteria-killing properties together have been developed,showing better performance for combating surface-attached bacteria and preventing formation of biofilms.In this review,we summarize the recent development of these dual-function antibacterial surfaces.We focus on the design principles and fabrication strategies of such surfaces and highlight the representative examples,which are categorized specifically into two types according to the anti-adhesive and bactericidal properties are simultaneous or switchable.A brief perspective is finally presented on current challenges and future research directions.

关键词： Antibacterial surfaces bactericidal property Biocides Anti-adhesive Antifouling

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