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Engineered Biomimetic Platelet Membrane-Coated Nanoparticles Block Staphylococcus aureus Cytotoxicity and Protect Against Lethal Systemic Infection

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Engineering 2021年第8期7卷 1149-1156页

作者： Jwa-Kyung Kim Satoshi Uchiyama Hua Gong Alexandra Stream Liangfang Zhang Victor Nizet Division of Nephrology Department of Internal Medicine&Kidney Research InstituteHallym University Sacred Heart HospitalAnyang 14068Republic of Korea Department of Clinical Immunology Hallym University Sacred Heart HospitalAnyang 14068Republic of Korea Division of Host-Microbe Systems and Therapeutics Department of PediatricsUniversity of California San DiegoLa JollaCA 92093USA Department of NanoEngineering University of California San DiegoLa JollaCA 92093USA Moores Cancer Center University of California San Diego HealthLa JollaCA 92037USA Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San DiegoLa JollaCA 92093USA

Staphylococcus aureus(***)is a leading human pathogen capable of producing severe invasive infections such as bacteremia,sepsis,and endocarditis with high morbidity and mortality,exacerbated by the increasingly widespread antibiotic resistance exemplified by methicillin-resistant strains(MRSA).*** pathogenesis is fueled by the secretion of toxins—such as the membrane-damaging pore-forming atoxin,which have diverse cellular targets including the epithelium,endothelium,leukocytes,and ***,we examine the use of human platelet membrane-coated nanoparticles(PNPs)as a biomimetic decoy strategy to neutralize *** toxins and preserve host cell defense *** PNPs blocked platelet damage induced by *** secreted toxins,thereby supporting platelet activation and bactericidal ***,the PNPs blocked macrophage damage induced by *** secreted toxins,thus supporting macrophage oxidative burst,nitric oxide production,and bactericidal activity,and diminishing MRSA-induced neutrophil extracellular trap *** a mouse model of MRSA systemic infection,PNP administration reduced bacterial counts in the blood and protected against *** together,the results from the present work provide a proof of principle of the therapeutic benefit of PNPs in toxin neutralization,cytoprotection,and increased host resistance to invasive *** infection.

关键词： Nanoparticle Nanosponge Platelet Staphylococcus aureus bacterial toxins Sepsis

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Helicobacter pylori virulence genes

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World Journal of Gastroenterology 2019年第33期25卷 4870-4884页

作者： Anja Sterbenc Erika Jarc Mario Poljak Matjaz Homan Institute of Microbiology and Immunology Faculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia Department of Gastroenterology Hepatology and NutritionUniversity Children’s HospitalFaculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia

Helicobacter pylori(***)is one of the most important human pathogens,infecting approximately half of the global *** its high prevalence,only a subset of *** infected individuals develop serious gastroduodenal *** pathogenesis of *** infection and disease outcome is thus thought to be mediated by an intricate interplay between host,environmental and bacterial virulence *** has adapted to the harsh milieu of the human stomach through possession of various virulence genes that enable survival of the bacteria in the acidic environment,movement towards the gastric epithelium,and attachment to gastric epithelial *** virulence factors enable successful colonization of the gastric mucosa and sustain persistent *** infection,causing chronic inflammation and tissue damage,which may eventually lead to the development of peptic ulcers and gastric *** studies have focused on the prevalence and role of putative *** virulence genes in disease *** several virulence factors with various functions have been identified,disease associations appear to be less evident,especially among different study *** review presents key findings on the most important *** virulence genes,including several bacterial adhesins and toxins,in children and adults,and focuses on their prevalence,clinical significance and potential relationships.

关键词： Helicobacter pylori Virulence genes Disease association Children Adults Outer membrane proteins bacterial toxins

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