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A biomimetic spore nanoplatform for boosting chemodynamic therapy and bacteria-mediated antitumor immunity for synergistic cancer treatment

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 106-118页

作者： Cuixia Zheng Lingling Sun Hongjuan Zhao Mengya Niu Dandan Zhang Xinxin Liu Qingling Song Weijie Zhong Baojin Wang Yun Zhang Lei Wang Huaihe Hospital of Henan University Translational medicine Center Weihai Municipal Hospital Cheeloo College of Medicine Shandong University School of Pharmaceutical Sciences Zhengzhou University Pingyuan Lab Henan Normal University Gynecology the Third Affiliated Hospital of Zhengzhou University

bacterial-based antitumor immunity has become a promising strategy to activate the immune system for fighting ***,the potential application of bacterial therapy is hindered by the presence of instability and susceptibility to infections within bacterial ***,monotherapy is ineffective in completely eliminating complex cancer with multiple contributing *** this study,based on our discovery that spore shell （SS） of Bacillus coagulans exhibits excellent tumor-targeting ability and adjuvant activity,we develop a biomimetic spore nanoplatform to boost bacteria-mediated antitumor therapy,chemodynamic therapy and antitumor immunity for synergistic cancer *** detail,SS is separated from probiotic spores and then attached to the surface of liposome （Lipo） that was loaded with hemoglobin （Hb）,glucose oxidase （GOx） and JQ1to construct SS@Lipo/Hb/GOx/*** tumor tissue,highly toxic hydroxyl radicals （·OH）are generated via sequential catalytic reactions:GOx catalyzing glucose into H2O2and Fe2+in Hb decomposing H2O2into·*** combination of·OH and SS adjuvant can improve tumor immunogenicity and activate immune ***,JQ1-mediated down-regulation of PD-L1 and Hb-induced hypoxia alleviation synergistically reshape immunosuppressive tumor microenvironment and potentiate immune *** this manner,SS@Lipo/Hb/GOx/JQ1 significantly suppresses tumor growth and *** summarize,the nanoplatform represents an optimum strategy to potentiate bacteria-based cancer immunotherapy.

关键词： Biomimetic spore shell bacteria-mediated antitumor therapy Chemodynamic therapy Immunotherapy Tumor microenvironment

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