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Genome-Wide DNA Binding of GBF1 IsModulated by Its Heterodimerizing ProteinPartners, HY5 and HYH

Molecular Plant 2014年第2期7卷 448-451页

作者： Hathi Ram Pushp Priya Mukesh Jain Sudip Chattopadhyay National Institute of Plant Genome Research Aruna Asaf Ali Marg New Delhi 110067 India Department of Biotechnology National Institute of Technology Mahatma Gandhi Avenue Durgapur 713209 India

Dear Editor, In today＇s post-genomic era where direct targets of manytranscription factors have been identified, it is becomingincreasingly evident that transcriptional networks are verycomplex. Heterodimerization of transcription factors is oneof the several methods by which these complex transcrip-tional networks are formed. By heterodimerization, DNA-binding specificity and affinity, transactivation properties,and ultimately cell physiology might be altered （Naar et al.,2001）. The formation of heterodimers has the potential torecognize additional binding sites and increase the rangeof DNA-binding specificity （Foster et al., 1994）. Further, het-erodimerization also allows the production of new proteinconfigurations. For example, the protein STF1 from soybeancan dimerize with GBF proteins and this dimerization bringstogether the acidic region from STF1 and the proline-richregion of the GBF proteins into one binding element （Cheonget al., 1998）. These results highlight the importance and/orconsequences of heterodimerization of transcription factorsat particular locus. However, to understand the complex tran-scriptional networks, it is important to investigate that howheterodimerization affects the whole-genome-wide bind-ing and transcriptional properties of a transcription *** in this study, we have investigated genome-wide DNAbinding of bzip transcription factor GBF1, and analyzed theimportance of its heterodimerization with HY5 and HYH forits genome-wide binding. We have found that GBF1 bindingsites are enriched within the 1-kb regions upstream to thetranscription start sites of target genes. Moreover, the bind-ings of GBF1 to most of its targets are largely dependent onHY5, while HYH only affects the binding of GBF1 to somespecific sites.

关键词： TRANSCRIPTION FACTOR bzip proteins LIGHT

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