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blm helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibiting homologous recombination repair

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Cancer Biology & Medicine 2022年第8期19卷 1150-1171页

作者： Yangyang Kong Chang Xu Xiaohui Sun Hao Sun Xiaotong Zhao Ningning He Kaihua Ji Qin Wang Liqing Du Jinhan Wang Manman Zhang Yang Liu Yan Wang Qiang Liu Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China

Objective:We aimed to investigate the radiosensitizing efficacy of the poly-ADP-ribose polymerase(PARP)inhibitor,olaparib,and the Bloom syndrome protein(blm)helicase inhibitor,ML216,in non-small cell lung cancer(NSCLC)***:Radiosensitization of NSCLC cells was assessed by colony formation and tumor growth ***,the effects of ML216,olaparib,and radiation on cell and tumor proliferation,DNA damage,cell cycle,apoptosis,homologous recombination(HR)repair,and non-homologous end joining(NHEJ)repair activity were ***:Both olaparib and ML216 enhanced the radiosensitivities of olaparib-sensitive H460 and H1299 cells,which was seen as decreased surviving fractions and Rad51 foci,increased total DNA damage,andγH2AX and 53BP1 foci(Pblm helicase inhibitors for radiosensitizing NSCLC cells,and supported the model that blm inhibition sensitizes cells to PARP inhibitor-mediated radiosensitization,as well as providing the basis for the potential clinical development of this combination for tumors intrinsically resistant to PARP inhibitors and radiotherapy.

关键词： NSCLC PARP blm radiosensitization homologous recombination repair

Study on the selection of blm detector for C-ADS Injector Ⅱ

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Chinese Physics C 2014年第11期38卷 72-75页

作者：任广益曾鸣何源李裕熊李为民 National Synchrotron Radiation Lab University of Science and Technology of China Tsinghua University Institute of Modern Physics Chinese Academy of Sciences

The injector of C-ADS （Chinese Accelerator Driven Sub-critical System） project is a high current, fully super-conducting proton accelerator. Meanwhile, a blm system is indispensable for this facility, especially in low energy segments. This paper presents some basic simulations for 10 MeV proton by Monte Carlo program FLUKA, as well as the distributions on different secondary particles in three aspects： angular, energy spectrum, and current. These results are beneficial to selecting the detector type and its location and determining its dynamic range matching different requirements for both fast and slow beam loss. Furthermore, in this paper the major impact of the background is also analyzed, such as superconducting cavity X radiation and radiation caused by material activation. This work is meaningful in blm system research.

关键词： C-ADS FLUKA blm

PHOTOELECTRIC EFFECTS FROM COVALENTLY LINKED PHTHALOCYANINE COMPLEXES IN BOTH blm AND SnO_2 PHOTOVOLTAIC CELL

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Chinese Chemical Letters 1992年第7期3卷 565-568页

作者： Zhi Chu BI Xin Li ZHAO Yue Ying QIAN Shu Yin SHEN Jia Yong YU Hui Jun XU Institute of Photographic Chemistry Academia Sinioa Beijing 100101

Covalently linked phthalocyanine complexes were incorporated in bilayer lipid membranes(BLN) and deposited on SnO_2 transparent electrodes, Their photovoltages were measured and compared. It has been found that a more favorable orientation and closer proximity are attained in the diad compounds between the donor (phthalocyanine)-acceptor(anthraquinone) pair than in the simple compound for efficient light-induced charge separation and transfer. The triad compound is the best among all tested compounds.

关键词： blm PHOTOELECTRIC EFFECTS FROM COVALENTLY LINKED PHTHALOCYANINE COMPLEXES IN BOTH blm AND SnO2 PHOTOVOLTAIC CELL SnO

The blm realization for the integral form of U_v(gl_(m|n))

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Science China Mathematics 2019年第2期62卷 351-370页

作者： Xiaoyu Chen Department of Mathematics Ningbo University

In this paper, we embed the integral form of the quantum supergroup U_v(gl_(m|n)) to the product of a family of integral quantum Schur super algebras. We show that the image of the embedding is a free Z[v, v^(-1)]-module by finding the basis explicitly and calculating the fundamental multiplication formulas of these bases. Unlike the non-super case, the fundamental multiplication formula, which is the key step, is more complicated since we have to deal with the case of multiplying the odd root vectors. As a consequence, via the base change, we realize the quantum supergroup at roots of unity as a subalgebra of the product of quantum Schur superalgebras. Thus, we find a new basis of quantum supergroups at odd roots of unity which comes from quantum Schur superalgebras.

关键词： quantum supergroup quantum Schur superalgebra blm basis integral form

Evaluate the Accuracy of Fargas and blm Models for Identification of Erosion Intensity

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Open Journal of Geology 2016年第11期6卷 1457-1468页

作者： Naser Abdi Department of Geology Ahar Branch Islamic Azad University Ahar Iran

Erosion process not only changes the land use to badlands, but also produces sediments that are dumped in the dam reservoirs, reduces the reservoir volume and finally makes it useless. So, it is necessary to do study on erosion intensity and the sediment production evaluation for which there are some methods and models. The experimental Fargas and blm models are largely used for this issue, in Iran as well as many other countries, separately or together based on the data availability. These studies results are as data for sediment supply estimation in different watershed management studies. So, the result accuracy is important for determination of sediment occurrence. This study evaluates these models’ results accuracy, in order to find the limitations and any solutions. Therefore, these two models were used and run in the same area, Aghbolagh drainage basin, Iran;the results were compared and evaluated. These models are based on some factors like rock type, drainage density, surface erosion and litter cover. The study includes field and laboratory analysis. The data were combined in GIS software and processed. The results reveal that, Fargas model predicts 3.67%, 14.26% and 81.06% of the area susceptible for high, severe and very severe erosion respectively;whilst, referring to blm model outcome, 42.96% area has high sensitivity;42.96% and 24.94% of the area have high and severe sensitivity for erosion, respectively. Furthermore, both models show same severity for around 18% of the study area. So, for these two models results very low similarities are concluded, which could be an indication of low reliability of the results, especially when they are used separately without any combination or comparison. Finally, it is recommended to use both of them together, or use another method beside each mentioned models.

关键词： Erosion Fargas GIS blm Sediment

BLAP75蛋白与DNA螺旋酶blm以及拓扑异构酶TopoⅢα的相互作用

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军事医学 2013年第5期37卷 358-362页

作者：徐畅陈凤华杜利清王彦曹嘉吴红英刘强中国医学科学院北京协和医学院放射医学研究所天津市分子核医学重点实验室天津300192

目的确定BLAP75蛋白与blm蛋白及TopoⅢα蛋白的相互作用及作用位点。方法构建一系列携带MBP标记的不同BLAP75载体,通过体外纯化蛋白结合实验检测BLAP75与blm、TopoⅢα的相互作用位点,并在真核细胞中通过免疫共沉淀方法进行验证;运用RN... 详细信息

目的确定BLAP75蛋白与blm蛋白及TopoⅢα蛋白的相互作用及作用位点。方法构建一系列携带MBP标记的不同BLAP75载体,通过体外纯化蛋白结合实验检测BLAP75与blm、TopoⅢα的相互作用位点,并在真核细胞中通过免疫共沉淀方法进行验证;运用RNA干扰(RNAi)技术特异性抑制BLAP75的表达,并利用West-ern印迹法检测其对blm和TopoⅢα蛋白表达的影响。结果 BLAP75与blm和TopoⅢα蛋白的结合位点位于BLAP75的N端区域;BLAP75与blm的直接相互作用需要DNA的介导;当BLAP75蛋白表达量减少时,blm和TopoⅢα蛋白量也随之减少。结论细胞内blm和TopoⅢα蛋白均结合在BLAP75的氨基端部分;BLAP75对TopoⅢα和blm的蛋白水平具有重要影响。

关键词：布卢姆综合征 BLAP75 DNA螺旋酶类 blm DNA拓扑异构酶 TopoⅢα

外加电场对平板膜(blm)中单体菌紫质分子bR光电响应的影响

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生物物理学报 1990年第1期6卷 25-30页

作者：胡坤生,王大辉,谈曼琪中国科学院生物物理研究所中国科学院生物物理研究所中国科学院生物物理研究所北京北京北京

本文研究了外加电场对单体菌紫质分子在平板膜系统中光电响应的影响.外加正电场时(外池为正,内池为负),光电响应信号变小,电场加至+52mV时,光电响应信号极性发生反转.外加负电场时,光电响应信号增大.本文提出了极性发生反转的可能模型,... 详细信息

本文研究了外加电场对单体菌紫质分子在平板膜系统中光电响应的影响.外加正电场时(外池为正,内池为负),光电响应信号变小,电场加至+52mV时,光电响应信号极性发生反转.外加负电场时,光电响应信号增大.本文提出了极性发生反转的可能模型,并对其机理进行了初步探讨.

关键词：菌紫质紫膜脂质脂类 bR blm 光电响应单体外加电场平板膜分子

三[二(苯甲酰基)甲烷]合铁(Ⅲ)的穆斯堡尔谱及其修饰的 blm 的伏安性质

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化学通报 1991年第2期 42-44页

作者：周精玉邰子厚陆轻铀南京大学配位化学研究所 210008 南京大学物理系 210008

在生物体中,对维持生命所必需的各种离子透过细胞膜时,均有各自的运送方式。通常,人们把可以诱导生物膜或人工膜的离子渗透力的有机配体(天然的或人工合成的)统称为离子载体,它们的分子量大约为200—2000道尔顿。

关键词：生物膜 blm 伏安性质穆斯堡尔谱

缬氨霉素对紫膜碎片双层平板脂膜(blm)光电响应的影响

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生物物理学报 1991年第2期7卷 179-182页

作者：胡坤生谈曼琪石志远彭程航中国科学院生物物理研究所北京100080

本实验中测量了缬氨霉素对双层平板膜系统的电性质和紫膜碎片blm上光电响应的作用.实验结果表明:缬氨霉素对K^+很灵敏,它可使大豆磷脂blm的膜电阻下降近四个量级,膜的稳定性也下降.它对Na^+也有作用,但其作用不如K^+那么明显.在缬氨霉... 详细信息

本实验中测量了缬氨霉素对双层平板膜系统的电性质和紫膜碎片blm上光电响应的作用.实验结果表明:缬氨霉素对K^+很灵敏,它可使大豆磷脂blm的膜电阻下降近四个量级,膜的稳定性也下降.它对Na^+也有作用,但其作用不如K^+那么明显.在缬氨霉素作用下,K^+对紫膜碎片blm光电响应的影响十分明显,它可以使光电压完全消失.Na^+对紫膜碎片blm的作用则比K^+的作用小得多.

关键词：紫膜 blm 结页氨霉素光电响应