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RNA-seq analysis reveals the critical role of the novel lnc RNA biancr in intramuscular adipogenesis through the ERK1/2 signaling pathway

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Journal of Animal Science and Biotechnology 2023年第3期14卷 917-935页

作者： Xinhao Ma Xinran Yang Dianqi Zhang Wenzhen Zhang Xiaoyu Wang Kuncheng Xie Jie He Chugang Mei Linsen Zan College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100People’s Republic of China Xi’an Dairy Cow Breeding Center Xi’an Agriculture and Rural BureauXi’anShaanxi 712100People’s Republic of China National Beef Cattle Improvement Center Northwest A&F UniversityYanglingShaanxi 712100People’s Republic of China

Background Long non-coding RNAs(lncRNAs)regulate numerous biological processes,including adipogenesis.Research on adipogenesis will assist in the treatment of human metabolic diseases and improve meat quality in livestock,such as the content of intramuscular fat(IMF).However,the significance of lncRNAs in intramuscular adipogenesis remains unclear.This research aimed to reveal the lncRNAs transcriptomic profiles in the process of bovine intramuscular adipogenesis and to identify the lncRNAs involved in the adipogenesis of bovine intramuscular adipocytes.Results In this research,a landscape of lncRNAs was identified with RNA-seq in bovine intramuscular adipocytes at four adipogenesis stages(0 d,3 d,6 d,and 9 d after differentiation).A total of 7035 lncRNAs were detected,including 3396 novel lncRNAs.Based on the results of differential analysis,co-expression analysis,and functional prediction,we focused on the bovine intramuscular adipogenesis-associated long non-coding RNA(biancr),a novel lncRNA that may have an important regulatory function.The knockdown of biancr inhibited proliferation and promoted apoptosis of intramuscular preadipocytes.Moreover,biancr knockdown inhibited intramuscular adipogenesis by regulating the ERK1/2 signaling pathway.Conclusion This study obtained the landscape of lncRNAs during adipogenesis in bovine intramuscular adipocytes.biancr plays a crucial role in adipogenesis through the ERK1/2 signaling pathway.The results are noteworthy for improving beef meat quality,molecular breeding,and metabolic disease research.

关键词： Adipogenesis biancr Bovine Intramuscular adipocyte LncRNAs

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