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Preparation and characterization of bioactive glass tablets and evaluation of bioactivity and cytotoxicity in vitro

Bioactive Materials 2018年第3期3卷 315-321页

作者： Jianhui Chen Lei Zeng Xiaofeng Chen Tianshun Liao Jiafu Zheng Department of Biomedical Engineering School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510641China National Engineering Research Center for Tissue Restoration and Reconstruction Guangzhou 510006China Key Laboratory of Biomedical Materials and Engineering Ministry of EducationSouth China University of TechnologyGuangzhou 510006China

In this study, the SiO2eCaOeP2O5 ternary component of bioactive glass particles were successfullysynthesized by sol-gel method, then the bioactive glass particles were pressed into tablets with drypressing molding technology. The physicochemical structure, in-vitro bioactivity and biocompatibility ofBG tablets were characterized by various methods, such as XRD、SEM、FTIR, etc. The results showedthat the sol-gel bioactive glass particle was distinguished with its amorphous structure and micron-size.After being soaked in Tris-Hcl solution for 15 d, the bioactive glass tablets didn't collapse. Also, themineralization assay in vitro showed that the bioactive glass tablets had good capability of inducing theformation of hydroxycarbonate apatite (HCA) after being immersed in simulated body fluid (SBF). Inaddition, the cytotoxicity assay indicated that the osteoblast (MC3T3) grew well on the surface ofbioactive glass tablets. According to the above results, the bioactive glass tablets presented good mechanicalstrength, excellent apatite-forming activity and high biocompatibility, which demonstratedtheir potential applications in the field of bone defect repairing.

关键词： Sol-gel bioactive glass Dry pressing molding BG tablets Bioactivity Cytotoxicity

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