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Chinese Medical Journal 2005年第16期118卷 1384-1387页

作者： WANG Ru-xing LI Xiao-rong JIANG Wen-ping LIU Zhi-hua YANG Xiang-jun XIAO Chun-hui SHAO Li-zheng ZHU Jian-qiu Department of Cardiology First People＇ s Hospital of Wuxi City and First Affiliated Hospital of Nanjing Medical University in Wuxi Wuxi 214002 China Department of Cardiology First Affiliated Hospital of Soochow University Suzhou 215006 China

In recent years, the indications of cardiac pacing have extended continuously with the rapid development of pacing technique. Pacemaker treatment has not only limited in arrhythmias of bradycardia and the number of pacemaker treatment has increased year by year. However, more and more new congestive heart failure （ CHF ） and aggravated CHF have appeared in patients after pacing therapy. Therefore, it is a hot topic that how to select reasonable pacing mode to reduce CHF occurrence or relieve CHF symptoms in patients with CHF.

关键词： b-type natriuretic peptide pacing mode congestive heart failure physiologic pacing ·non-physiologic pacing

Effects of short-acting β-adrenergic blocker on b-type natriuretic peptide at early stage of postresuscitation in rabbits

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Chinese Medical Journal 2006年第10期119卷 864-867页

作者： LI Xiang LI Pei-jie HE Yun-fen ZENG Hong LI Zi-li ZHANG Zheng-yi CAO Wen YANG Lan Department of Emergency Centre Second Hospital LanzhouUniversity Lanzhou 730000 China Department of Geratology First People Hospital of JiujiangJiujiang 332000 China Department of Emergency Centre Beijing Chaoyang HospitalBeijing 100043 China

Postresuscitation myocardial dysfunction is reversible heart failure and b-type natriuretic peptide （bNP） is a biochemical marker of ventricular disorders secreted from ventricle, which can be used to assess the status of left ventricular function. This study investigated the effect of β-adrenergic blocker on concentration of bNP and cardiac function after cardiopulmonary resuscitation in rabbits.

关键词： cardiac arrest cardiopulmonary resuscitation myocardial dysfunction b-type natriuretic peptide adrenergic blocker

Marked elevation of b-type natriuretic peptide in patients with heart failure and preserved ejection fraction

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The Journal of biomedical Research 2014年第4期28卷 255-261页

作者： Samuel Tate Andrea Griem blythe Durbin-Johnson Clifton Watt Saul Schaefer Department of Internal Medicine Division of Cardiovascular MedicineUniversity of California DavisDavisCAUSA Department of Public Health Sciences Division of BiostatisticsUniversity of California DavisDavisCAUSA Cardiology Section Department of Veteran AffairsNorthern California Health Care SystemMatherCAUSA

Marked elevations of b-type natriuretic peptide （bNP） are not generally seen in patients with heart failure and preserved ejection fraction （HFpEF）. The objective of this study was to examine the clinical and laboratory characteristics of a large cohort of patients with HFpEF and markedly elevated bNP. A retrospective examination of 421 inpatients at a university hospital admitted with a diagnosis of HFpEF was performed. Clinical and echocardiographic data in 4 groups of patients with levels of bNP ≤ 100 pg/mL, 100-400 pg/mL, 400-1,000 pg/mL and 〉 1,000 pg/mL were compared. Patients with HFpEF and bNP 〉 1,000 pg/mL （28% of the population） were characterized by impaired renal function and greater use of anti-hypertensive medications. A subset of these patients with bNP 〉 1,000 pg/mL had normal renal function （21%） and were significantly older, more frequently female, and tended to have lower ejection fractions. Conversely, patients with HFpEF and bNP ≤100 pg/mL were younger and had preserved renal function. bNP was inversely related to the likelihood of subsequent admission for heart failure, but not to myocardial infarction or death. In conclusion： bNP 〉 1,000 pg/mL is seen in almost 1/3 of patients hospitalized with HFpEF. This elevation of bNP often reflects impaired renal function, but can also be seen in patients with preserved renal function but relatively impaired systolic function.

关键词： b-type natriuretic peptide diastolic heart failure chronic kidney disease

The Utility of b-type natriuretic peptide to Predict Prognosis of Acute Myocardial Infarction Patients Complicated With Cardiogenic Shock Treated With Intra-aortic ballon Counterpulsation

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South China Journal of Cardiology 2008年第1期9卷 22-25页

作者：谢江王显谭琛 Lung-Heart Center of beijing Military Hospital

Objectives To assess the prognostic value of b-type natriuretic peptide （bNP） in severe AMI patients treated with intra-aortic ballon counterpulsation（IAbP）. Methods A total of 42 AMI patients with cardiogenic shock were retrospectively studied. bNP plasma level was recorded in the 24th hour and 4th day after myocardial infarction. The different mortality were compared among patients with different bNP levels. Results With aggressive treatment, 20 patients survived short term hospitalization. Plasma concentration of bNP in dying patients is much higher than in survivals（1369 ± 353 vs 651 ± 302 pg/ml. P〈 0.01）.Patients with bNP higher than 1474 pg/mL had a mortality of 92.9 %. Conclusions Elevated bNP level in AMI patients with cardiogenic shock treated with IAbP is highly associated with poor prognosis.

关键词： acute myocardial infarction cardiogenic shock b-type natriuretic peptide

b-type natriuretic peptide in predicting the severity of community-acquired pneumonia

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World Journal of Emergency Medicine 2015年第2期6卷 131-136页

作者： Jing Li Huan Ye Li Zhao Department of Emergency Medicine Fuxing HospitalCapital Medical University

bACKGROUND: Although pneumonia severity index(PSI) is widely used to evaluate the severity of community-acquired pneumonia(CAP), the calculation of PSI is very complicated. The present study aimed to evaluate the role of b-type natriuretic peptide(bNP) in predicting the severity of CAP.METHODS: For 202 patients with CAP admitted to the emergency department, bNP levels, cardiac load indexes, inf lammatory indexes including C-reactive protein(CRP), white blood cell count(WbC), and PSI were detected. The correlation between the indexes and PSI was investigated. bNP levels for survivor and non-survivor groups were compared, and a receiver operating characteristic(ROC) curve analysis was performed on the bNP levels versus PSI.RESULTS: The bNP levels increased with CAP severity(r=0.782, PbNP levels of the high-risk group(PSI classes IV and V) were signifi cantly higher than those of the low-risk group(PSI classes I–III)(PbNP levels were signifi cantly higher in the non-survivor group than in the survivor group(Pbetween bNP levels and PSI scores(r=0.782, PbNP level was highly accurate in predicting the severity of CAP(AUC=0.952). The optimal cut-off point of bNP level for distinguishing high-risk patients from low-risk ones was 125.0 pg/m L, with a sensitivity of 0.891 and a specifi city of 0.946. Moreover, bNP level was accurate in predicting mortality(AUC=0.823). Its optimal cut-off point for predicting death was 299.0 pg/m L, with a sensitivity of 0.675 and a specifi city of 0.816. Its negative predictive cut-off value was 0.926, and the positive predictive cut-off value was 0.426.CONCLUSION: bNP level is positively correlated with the severity of CAP, and may be used as a biomarker for evaluating the severity of CAP.

关键词： Community-acquired pneumonia b-type natriuretic peptide Pneumonia severity index biomarker Emergency Disease severity assessment

Effects and safety of natriuretic peptides as treatment of cirrhotic ascites:A systematic review and meta-analysis

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World Journal of Hepatology 2022年第4期14卷 827-845页

作者： Rasmus Hvidbjerg Gantzel Mikkel breinholt Kjær Peter Jepsen Niels Kristian Aagaard Hugh Watson Lise Lotte Gluud Henning Grønbæk Department of Hepatology and Gastroenterology Aarhus University HospitalAarhus N 8200Denmark Gastroenterology Unit Copenhagen University HospitalHvidovre 2650Denmark Department of Clinical Medicine University of CopenhagenHvidovre 2650Denmark

bACKGROUND natriuretic peptides are involved in the cascade of pathophysiological events occurring in liver cirrhosis,counterbalancing vasoconstriction and anti-natriuretic factors.The effects of natriuretic peptides as treatment of cirrhotic ascites have been investigated only in small studies,and definitive results are lacking.AIM To examine the effects and safety of natriuretic peptides in cirrhosis patients with ascites.METHODS We searched MEDLINE,Web of Science,Scopus,Cochrane Library and Embase for all available studies applying intravenous administration of any natriuretic peptide to patients suffering from cirrhotic ascites.Inclusion was not limited by treatment duration or dose,or by follow-up duration.both randomised controlled trials and non-randomised studies were eligible for inclusion.The primary outcome was change in renal sodium excretion.Secondary outcomes included safety measures and changes in renal water excretion,plasma aldosterone concentration,and plasma renin activity.RESULTS Twenty-two studies were included.Atrial natriuretic peptide(ANP)was the only intensively studied treatment.Sodium excretion increased in response to continuous ANP infusion and was more pronounced when infusion rates of>30 ng/kg/min were administered compared with≤30 ng/kg/min(Pbgroups with mild/moderate ascites compared with moderate/severe and refractory ascites(Pbaseline in study subgroups achieving a negative sodium balance in response to an ANP administration compared with treatment non-responders(Pblood pressure decreases occurred less frequently when ANP doses≤30 ng/kg/min were applied.The quality of evidence for a natriuretic response to ANP was low,mainly due to small sample sizes and considerable between-study heterogeneity.D

关键词： Atrial natriuretic peptide b-type natriuretic peptide Urodilatin Cirrhosis Ascites Refractory ascites

Cardiac biomarkers in children with congenital heart disease

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World Journal of Pediatrics 2015年第4期11卷 309-315页

作者： Masaya Sugimoto Seiko Kuwata Clara Kurishima Jeong Hye Kim Yoich Iwamoto Hideaki Senzaki Department of Pediatrics Asahikawa Medical UniversityAsahikawaJapan Department of Pediatric Cardiology Saitama Medical CenterSaitama Medical UniversityKawagoeJapan

background:Most congenital heart diseases(CHDs)have specific hemodynamics,including volume and pressure overload,as well as cyanosis and pulmonary hypertension,associated with anatomical abnormalities.Such hemodynamic abnormalities can cause activation of neurohormones,inflammatory cytokines,fibroblasts,and vascular endothelial cells,which in turn contribute to the development of pathologic conditions such as cardiac hypertrophy,fi brosis,and cardiac cell damages and death.Measuring biomarker levels facilitates the prediction of these pathological changes,and provides information about the stress placed on the myocardial cells,the severity of the damage,the responses of neurohumoral factors,and the remodeling of the ventricle.Compared to the ample information on cardiac biomarkers in adult heart diseases,data from children with CHD are still limited.Data sources:We reviewed cardiac biomarkers-specifi cally focusing on troponin as a biomarker of myocardial damage,amino-terminal procollagen type III peptide(PIIIP)as a biomarker of myocardialfi brosis and stromal remodeling,and b-type natriuretic peptide(bNP)/N-terminal probNP as biomarkers of cardiac load and heart failure,by introducing relevant publications,including our own,on pediatric CHD patients as well as adults.Results:Levels of highly sensitive troponin I are elevated in patients with atrial septal defects(ASDs)and ventricular septal defects(VSDs).PIIIP levels are also elevated in patients with ASD,VSD,pulmonary stenosis,and Tetralogy of Fallot.Measurement of bNP and N-terminal probNP levels shows good correlation with heart failure score in children.Conclusions:In the treatment of children with CHD requiring delicate care,it is vital to know the specifi c degree of myocardial damage and severity of heart failure.Cardiac biomarkers are useful tools for ascertaining the condition of CHDs with ease and are likely to be useful in determining the appropriate care of pediatric cardiology patients.

关键词： biomarker b-type natriuretic peptide congenital heart disease procollagen type III peptide troponin

Correlation between Histone Deacetylase 9 and Regulatory T Cell in Patients with Chronic Heart Failure

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Current Medical Science 2018年第2期38卷 199-203页

作者： Ping-ping LIAO Li-hua LIU bin WANG Xin FANG Shao-qiong ZHOU Wei LI Yan-qing ZHANG Si-ming GUAN Department of Geriatrics the Affiliated Hospital of Qingdao University Qingdao 266003 China Department of Geriatrics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Heart failure （HF） is the end stage of various kinds of cardiovascular diseases and leads to a high mortality worldwide. Numerous studies have demonstrated that frequencies of CD4＋CD25＋Foxp3＋ regulatory T cells （Tregs） are reduced in HF patients and properly expanding Tregs attenuates HF progression. Histone deacetylase （HDAC） 9 has been revealed to contribute to several cardiovascular and cerebrovascular diseases. Plenty of studies showed that HDAC9 negatively regulated the number and function of Tregs. Thus, we aim to investigate the expression of HDAC 9 in patients with chronic heart failure （CHF） and the relationship among HDAC9, Tregs and CHF. Our research showed a reduced number of Tregs and an increased expression of HDAC9 mRNA in CHF patients. Patients with CHF were divided into two groups by heart function grade of New York Heart Association （NYHA）, we found that the HDAC9 mRNA expression level in NYHA grade Ⅱ -Ⅲ group were lower than that in NYHA grade IV group. More importantly, the correlation study suggested that the expression of HDAC9 mRNA was negatively correlated to Tregs frequency and left ventricular ejection fraction （LVEF）, whereas positively correlated to larger left ventricular end-diastolic dimension （LVEDD） and b-type natriuretic peptide （bNP） in patients with CHF. The correlation studies also showed a positive correlation between HDAC9 and the severity of CHF. Our research suggests that HDAC9 may be a new indicator for assessing CHF and it may offer a new direction for research of CHF.

关键词： histone deacetylase 9 heart failure regulatory T cells b-type natriuretic peptide