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Impact of exercise on markers of b cell-related immunity:A systematic review

Journal of Sport and Health Science 2024年第3期13卷 339-352,I0002页

作者： David Walzik Sergen belen Karen Wilisch Marie Kupjetz Silvana Kirschke Tobias Esser Niklas Joisten Alexander Schenk Sebastian Proschinger Philipp Zimmer Division of Performance and Health(Sports Medicine) Institute for Sport and Sport ScienceTU Dortmund UniversityDortmund 44227Germany

background:b cells represent a crucial component of adaptive immunity that ensures long-term protection from infection by generating pathogen-specific *** alters b cell counts and immunoglobulin levels,but evidence-based conclusions on potential benefits for adaptive immunity are *** systematic review assessed current literatures on the impact of acute exercise and exercise training on b cells,immunoglobulins,and markers of secretory immunity in human ***:According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,MEDLINE,Web of Science,and Embase were searched on March 8,***-randomized controlled trials and crossover trials investigating the impact of acute exercise or exercise training on b cell counts and proportions,immunoglobulin levels,salivary flow rate,or secretory immunoglobulin A secretion rate were *** and reporting of exercise training studies were assessed using the Tool for the Assessment of Study Quality and reporting in *** characteristics,outcome measures,and statistically significant changes were summarized ***:Of the 67 eligible studies,22 applied acute exercise and 45 applied exercise *** included outcomes revealed significant alterations over time in acute exercise and exercise training context,but only a few investigations showed significant differences compared to control *** and plasma immunoglobulin A levels were most consistently increased in response to exercise ***:b cell-related outcomes are altered by acute exercise and exercise training,but evidence-based conclusions cannot be drawn with high confidence due to the large heterogeneity in populations and exercise ***-designed trials with large sample sizes are needed to clarify how exercise shapes b cell-related immunity.

关键词： Antibody b-lymphocyte Exercise Humoral immunity Immune system

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Skewed CD39/CD73/adenosine pathway contributes to b-cell hyperactivation and disease progression in patients with chronic hepatitis b

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Gastroenterology Report 2021年第1期9卷 49-58,I0002页

作者： Shuang-Nan Zhou Ning Zhang Hong-Hong Liu Peng Xia Chao Zhang Jin-Wen Song Xing Fan Ming Shi Lei Jin Ji-Yuan Zhang Fu-Sheng Wang Medical School of Chinese PLA BeijingP.R.China Infectious Disease Treatment and Research Center The Fifth Medical Center of Chinese PLA General HospitalBeijingP.R.China Liver transplatation Center The Fifth Medical Center of ChinesePLA General HospitalBeijingP.R.China Department of Integrated TCM&Western Medicine The Fifth Medical Center of Chinese PLA General HospitalBeijingP.R.China International Center for Liver Disease Treatment The Fifth Medical Center of Chinese PLA General HospitalBeijingP.R.China

background:The mechanisms underlying b-cell hyperactivation in patients with chronic hepatitis b virus(HbV)infection remain largely *** present study assessed the clinical characteristics of the CD39/CD73/adenosine pathway in patients with chronic hepatitis b(CHb).Methods:We examined CD39 and CD73 expression and adenosine production by b-cells from 202 HbV-infected patients.b-cell-activation phenotypes were assessed by flow cytometry after CpG+CD40 ligand stimulation with or without blockade and activation of the adenosine ***:CD39 and CD73 expression on circulating b-cells was decreased in CHb patients with high HbV DNA,HbeAg positivity,high HbsAg levels,and active liver inflammation,and was hierarchically restored in complete responders according to HbeAg seroconversion or HbsAg ***,CD39 and CD73 expression on activated memory and tissue-like memory b-cell subsets in complete responders was not increased despite effective antiviral ***,CD39 and CD73 expression on intra-hepatic b-cells was decreased in inflammatory *** vitro,b-cells from CHb patients showed a markedly reduced capacity to generate CD39/CD73-dependent extracellular adenosine and expressed increased levels of activation markers after adenosine-production ***,metformin significantly reduced activation-marker expression via regulating AMP-activated protein ***:The skewed CD39 and CD73 expression on b-cells was associated with a high viral burden,liver inflammation,and antiviral efficacy in CHb patients,and the skewed CD39/CD73/adenosine pathway contributed to b-cell *** of the CD39/CD73/adenosine pathway using metformin may represent a therapeutic option to reverse HbVinduced immune pathogenesis.

关键词： hepatitis b virus b-lymphocyte CD39 5’-nucleotidase lymphocyte activation

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Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation

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Neuroimmunology and Neuroinflammation 2014年第1期1卷 147-152页

作者： Yi Guo Tarik Tihan Helen Kim Christopher Hess Michael T.Lawton William L.Young Yuan-Li Zhao Hua Su Department of Anaesthesia and Perioperative Care Center for Cerebrovascular ResearchSan FranciscoCA 94110USA Department of Pathology University of CaliforniaSan FranciscoSan FranciscoCA 94110USA Department of Radiology and biomedical Imaging University of CaliforniaSan FranciscoSan FranciscoCA 94110USA Department of Neurological Surgery University of CaliforniaSan FranciscoSan FranciscoCA 94110USA Department of Neurology University of CaliforniaSan FranciscoSan FranciscoCA 94110USA Department of Neurosurgery Affiliated Hospital of Hebei UniversityBaoding 071000HebeiChina Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 410011China

Aim:To test the hypothesis that lymphocyte infiltration in brain arteriovenous malformation(bAVM)is not associated with iron deposition(indicator of micro-hemorrhage).Methods:Sections of unruptured,previously untreated bAVM specimens(n=19)were stained immunohistochemically for T-lymphocytes(CD3+),b-lymphocytes(CD20+),plasma cells(CD138+)and macrophages(CD68+).Iron deposition was assessed by hematoxylin and eosin and Prussian blue *** temporal arteries(STA)were used as ***:both T-lymphocytes and macrophages were present in unruptured,previously untreated bAVM specimens,whereas few b cells and plasma cells were *** deposition was detected in 8 specimens(42%;95%confidence intervals=20-67%).The samples with iron deposition tended to have more macrophages than those without(666±313 vs.478±174 cells/mm2;P=0.11).T-cells were clustered on the luminal side of the endothelial surface,on the vessel-wall,and in the perivascular *** was no correlation between T-lymphocyte load and iron deposition(P=0.88).No macrophages and lymphocytes were detected in STA ***:T-lymphocytes were present in bAVM *** macrophages,the load and location of T-lymphocytes were not associated with iron deposition,suggesting the possibility of an independent cell-mediated immunological mechanism in bAVM pathogenesis.

关键词： b-lymphocyte human brain arteriovenous malformation inflammatory cells micro-hemorrhage T-lymphocyte

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Rituximab for the Treatment of Multiple Sclerosis: A Retrospective Observational Cohort in Morocco

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Case Reports in Clinical Medicine 2022年第10期11卷 448-456页

作者： Siham bouchal Nabila Lahmadi Sara Zejli Naima Chtaou Youssef Hafidi Faouzi belahsen Department of Neurology Hassan II University Teaching Hospital Fez Morocco Laboratory of Epidemiology Clinical Research and Health Community Faculty of Medicine and Pharmacy Sidi Mohammed Ben Abdellah University Fez Morocco Department of Pharmacology Hassan II University Teaching Hospital Fez Morocco

background: RITUXIMAb (RTX) is a chimeric anti-CD20 monoclonal antibody that has initially demonstrated efficacy in patients with b-cell lymphoma. Then, over time, it has demonstrated its efficacy in systemic inflammatory diseases and recently in neurological diseases such as multiple sclerosis (MS). Here we describe our experience with rituximab from one MS center from MOROCCO. Objectives: To investigate the safety and efficacy of Rituximab in MS in a Moroccan population. Methods: A retrospective uncontrolled observational single-center study from January 2017 to July 2020, was including all off-label Rituximab-treated patients with MS with at least 6 months of follow-up. Outcome data were collected and evaluated relapse rate, EDSS score, and adverse events (AEs) from the medical charts. Adverse events grade according to the Common Terminology Criteria for Adverse Events. Results: A total of 63 MS patients were treated with RTX, 47 patients were included, while 12 cases had just initiated treatment and 4 cases were lost to follow-up. The mean age of the patients was 39 ± 12 years with a female predominance (F/M: 1.6). All forms of MS were included, 83% of whom had relapsing-remitting MS. The duration of disease progression was 8 ± 5 years. Median EDSS before RTX initiation was 5.5 (0 - 7). 51% of patients were treated with RTX as second-line therapy after failure of other disease-modifying therapies, whereas 34% received it as first-line therapy. The annualized relapse rates decreased from 0.8 to 0.2 after RTX treatment. The Median EDSS remained unchanged at 71%. Radiological stability was noted in 83.7%, while 13.5% had a single new T2 lesion. Infusion-related AEs occurred during 27.6% of infusions and most were mild. Simple infection grades ≤ 2 were noted in 19%. Abortion occurred in only one patient. Conclusion: Our study confirms the usability of rituximab treatment for MS in the MOROCCO healthcare environment.

关键词： b-lymphocyte CD20 Multiple Sclerosis Rituximab Moroccan Population

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