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Change of serum b-cell activating factor level in patients with positive antiphospholipid antibodies and previous adverse pregnancy outcomes and its significance

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Chinese Medical Journal 2020年第19期133卷 2287-2294页

作者： Xin-Yi Li Hong-Ji Duan Xiang-Yuan Liu Xiao-Li Deng Department of Rheumatology and Immunology Peking University Third HospitalHaidian DistrictBeijing 100191China

background:b-cell activating factor(bAFF)is vital for b cell *** bAFF levels are elevated in thrombotic antiphospholipid syndrome,but little is known about levels in patients with positive antiphospholipid antibodies(aPLs)and previous adverse pregnancy outcomes(APOs).We aimed to analyze serum bAFF concentrations of these patients in early pregnancy along with different pregnancy ***:Thirty-six pregnant patients positive for aPLs and previous APOs(patient group),25 healthy pregnant females(HP group)and 35 healthy non-pregnant females(HNP group)from the Peking University Third Hospital,between October 2018 and March 2019,were enrolled in this *** of HNP and serum of patients as well as HP in the first gestational trimester were ***-linked immunosorbent assay kits were used to measure serum bAFF and interferon-alpha(IFN-a)*** bead array analysis was used to measure serum concentrations of *** patient group was further divided into APOs and non-APOs(NAPOs)group,fetal loss and live birth group according to pregnancy *** Mann-Whitney U-test was used to assess significance between and within *** rank-order was used to evaluate correlation coefficients between bAFF and related ***:The serum bAFF level in HP group was significantly lower than HNP group(245.24[218.80,265.90]vs.326.94[267.31,414.80]pg/mL,Z=-3.966,PbAFF level was obviously elevated in patient group compared to that in HP group(307.77[219.86,415.65]vs.245.24[218.80,265.90]pg/mL,Z=-2.464,P=0.013).bAFF levels in APOs group tended to be higher than that in NAPOs group(416.52[307.07,511.12]vs.259.37[203.59,375.81]pg/mL,Z=-2.718,P=0.006).Compared to HP group,concentrations of IFN-a,interleukin(IL-6)and tumor necrosis factor were higher in patient group(33.37[18.85,48.12]vs.13.10[6.85,25.47]pg/mL,Z=-2.023,P=0.043;39.16[4.41,195.87]vs.3.37[2.92,3.90]pg/mL,Z=-3.650,P<0.001;8.23[2.27,64.46]vs.1.53[1

关键词： Antiphospholipid syndrome b-cell activating factor Cytokine Inflammation Obstetrics

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