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Immunotherapeutic strategies targeting b cell maturation antigen in multiple myeloma

Military Medical Research 2021年第3期8卷 433-443页

作者： Yi Fang Jian Hou Department of Hematology Renji HospitalSchool of MedicineShanghai Jiao Tong University160 Pujian RoadShanghai 200127China

Multiple myeloma(MM) is the second most common hematologic malignancy, and is characterized by the clonal expansion of malignant plasma cells. Despite the recent improvement in patient outcome due to the use of novel therapeutic agents and stem cell transplantation, all patients eventually relapse due to clone evolution. b cell maturation antigen(bCMA) is highly expressed in and specific for MM cells, and has been implicated in the pathogenesis as well as treatment development for MM. In this review, we will summarize representative anti-bCMA immune therapeutic strategies, including bCMA-targeted vaccines, anti-bCMA antibodies and bCMA-targeted CAR cells. Combination of different immunotherapeutic strategies of targeting bCMA, multi-target immune therapeutic strategies, and adding immune modulatory agents to normalize anti-MM immune system in minimal residual disease(MRD) negative patients, will also be discussed.

关键词： b cell maturation antigen Multiple myeloma Vaccine Antibody CAR T-cells

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Anti-bCMA CAR-T cell Therapy in Relapsed or Refractory Multiple Myeloma Patients with Impaired Renal Function

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Current Medical Science 2021年第3期41卷 474-481页

作者： Shao-long HE Yu-hang CHENG Di WANG Meng-lei XU Yi-mei QUE Yan-jie XU Liang-ming MA Chun-rui LI Jian-feng ZHOU Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Third Hospital of Shanxi Medical University Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTongji Medical CollegeHuazhong University of Science and TechnologyTaiyuan 030032China

Anti-b cell maturation antigen(bCMA)chimeric antigen receptor(CAR)T-cell therapyis effective and well-tolerated for refractory or relapsed multiple myeloma(RRMM).The purposcof the present study was to analyze efficacy in RRMM patients with renal impairment treated byanti-bCMA CAR-T cell therapy.A total of 59 RRMM patients were selected,and divided intoimpaired renal function(lRF)group[basclinc cstimated giomerular filtration rate(eSFR)baseline eGFR≥90 mL/min/1.73 m,n=41).For patients with IRF,eGFR at the 6th month post-CAR-T cells infusion was significantlyhigher than the baseline(Pbeta-2 micro-globulin(bcta-2M)were associated factors with the decrease of serum ***-free survival(PFS)in the NRF group and IRF group was 266 days and 181 *** survival(OS)in the NRF group and lRF group was 877 days and 238 *** was no significant difference in the objective response rate(ORR)between thelRF group and the NRF *** is suggested that CAR-T cells therapy could improve the renalfunction during the treatment of *** renal function could be more significantly improvedin RRMM patients with light chain type than with other types.

关键词： relapsed or refractory multiple myeloma chimeric antigen receptor T-cell therapy impaired renal function b cell maturation antigen

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Characterization and high-yield production of non-N-glycosylated recombinant human bCMA-Fc in Pichia pastoris

Characterization and high-yield production of non-N-glycosyl...

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中国生物化学与分子生物学会2016年全国学术会议

作者： Weihua Hou Min Yu Ministry of Education and Department of biochemistry and Molecular biology School of Basic Medicine Fudan University

b-cell maturation antigen(bCMA)fused at the C-terminus to the Fc portion of human Ig G1(bCMA-Fc)blocks b-cellactivating factor(bAFF)-and proliferation-inducing ligand(APRIL)-mediated b-cell activation,leading to immune *** fusion protein has been cloned and produced by several engineering cell lines,To reduce cost and enhance production,we attempted to express recombinant human bCMA-Fc(rh bCMA-Fc)in Pichia pastoris under the control of the AOX1

关键词： APRIL b cell maturation antigen N-glycosylation Pichia pastoris recombinant human protein

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