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北京大学学报（医学版） 2006年第1期38卷 57-61页

作者： Gary LU John ZHANG Katherine PAUPER Department of Pathology and Genetics USLabs/LabCorp Irvine California 91612 USA Department of Hematology/Oncology Quest Diagnostics/Nichols Institute San Juan Capistrano CA 92692 USA

Objective: To study the frequency of interstitial 7q deletions in b-cell lymphoproliferative disorders (b-LPDs). Methods: Cases were collected from the clinical laboratory diagnosis database at USLabs/LabCorp over the past two years (2002 to 2004). Cases that showed deletions in the long arm of chromosome 7 were then reviewed. Interstitial deletions in the long arm of chromosome 7 were further investigated according to the indications for clinical laboratory studies and flow cytometry findings. The final clinical diagnosis for each case was obtained from the referring physician. Results: A total of 19 483 cases were included in this series. Eighty-five cases were observed to have either terminal or interstitial deletion in the long arm of chromosome 7. Of the 85 cases, 46 had interstitial deletions accounting for 54.1% of the 7q deletions combined. b-LPDs were found in 10 of the 46 cases, accounting for 21.7%. The b-LPDs associated with 7q interstitial deletions were diverse, including b-cell chronic lymphocytic leukemia (b-CLL) in five cases. The deleted region in the long arm of chromosome 7 in the 10 cases associated with b-LPDs was solely confined to the 7q22-q32 region. Conclusion: (1) The frequency of 7q interstitial deletions associated with b-LPDs is substantially high; (2) 7q interstitial deletions are not uncommon in b-CLL.

关键词：染色体缺失染色体白血病 b细胞慢性流式细胞术 7号染色体血液肿瘤 b淋巴细胞增生障碍

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