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Establishment of a new pig model for auxiliary partial orthotopic liver transplantation

World Journal of Gastroenterology 2005年第6期11卷 917-921页

作者： Cheng-HongPeng Liu-BinShi Hong-WeiZhang Shu-YouPeng Guang-WenZhou Hong-WeiLi transplantationCenter RuijinHospitalShanghai200025China transplantationCenter HuashanHospitalShanghai200040China DepartmentofGeneralSurgery theSecondAffiliatedHospitalMedicalCollegeZhejiangUniversityHangzhou310009ZhejiangProvinceChina

AIM: To establish a new pig model for auxiliary partial orthotopic liver transplantation (APOLT).METHODS: The liver of the donor was removed from its body. The left lobe of the liver was resected in vivo and the right lobe was used as a graft. After the left lateral lobe of the recipient was resected, end-to-side anastomoses of suprahepatic inferior vena cava and portal vein were performed between the donor and recipient livers,respectively. End-to-end anastomoses were made between hepatic artery of graft and splenic artery of the *** drainage was placed in donor common bile ***: Models of APOLT were established in 5 pigs with a success rate of 80%. Color ultrasound examination showed an increase of blood flow of graft on 5th d compared to the first day after operation. When animals were killed on the 5th d after operation, thrombosis of hepatic vein (HV) and portal vein (PV) were not found. Histopathological examination of liver samples revealed evidence of damage with mild steatosis and sporadic necrotic hepatocytes and focal hepatic lobules structure disorganized in graft. Infiltration of inflammatory cells was mild in portal or central vein area. Hematologic laboratory values and blood chemical findings revealed that compared with group A (before transplantation), mean arterial pressure (MAP), central venous pressure (CVP), buffer base (BB), standard bicarbonate (SB) and K+ in group B (after portal vein was clamped) decreased (P＜0.01). After reperfusion of the graft, MAP, CVP and K+ restored ***: Significant decrease of congestion in portal vein and shortened blocking time were obtained because of the application of in vitro veno-venous bypass during complete vascular clamping. This new procedure,with such advantages as simple vessel processing, quality anastomosis, less postoperative hemorrhage and higher success rate, effectively prevents ischemia reperfusion injury of the host liver and deserves to be spread.

关键词： auxiliary partial orthotopic liver transplantation Model pig

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Hepatofugal Portal Flow Associated with Acute Rejection in Living-donor auxiliary partial orthotopic liver transplantation:A Report of One Case and Literature Review

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2010年第6期30卷 824-826页

作者：魏来陈知水陈孝平杜敦峰李开艳蒋继贫 Institute of Organ transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Ultrasound Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

We report a case of reversible hepatofugal portal flow after auxiliary partial orthotopic liver transplantation (APOLT) from a living donor in this *** postoperative day 6,continuous hepatofugal portal flow was observed in the grafted liver without portal thrombosis and obstruction of the hepatic *** on histological findings,acute rejection was the suspected *** normal portal venous flow was restored after steroid pulse and antithymocyte globulin (ATG) *** patient was discharged on the 30th postoperative *** was concluded that hepatofugal flow after liver transplantation is a sign of serious acute rejection,and can be successfully treated by anti-rejection therapy.

关键词： hepatofugal flow auxiliary partial orthotopic liver transplantation living-donor liver transplantation acute rejection

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