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Plasma oxytocin and Arginine-vasopressin Levels in Children with autism spectrum disorder in China: Associations with Symptoms

引用

Neuroscience Bulletin 2016年第5期32卷 423-432页

作者： Hong-Feng Zhang Yu-Chuan Dai Jing Wu Mei-Xiang Jia Ji-Shui Zhang Xiao-Jing Shou Song-Ping Han Rong Zhang Ji-Sheng Han Neuroscience Research Institute Peking University Department of Neurobiology School of Basic Medical Sciences Peking University Health Science Center Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning Commission Peking University Center of Medical and Health Analysis Peking University Mental Health Institute Peking University Department of Neurology and Center of Rehabilitation Beijing Children’s Hospital Capital University of Medical Sciences

autism spectrum disorder（ASD） is defined by impairments of social interaction and the presence of obsessive behaviors. The ＇＇twin＇＇ nonapeptides oxytocin（OXT） and arginine-vasopressin（AVP） are known to play regulatory roles in social behaviors. However, the plasma levels and behavioral relevance of OXT and AVP in children with ASD have seldom been investigated. It is also unknown whether their mothers have abnormal plasma peptide levels. Here, using well-established methods of neuropeptide measurement and a relatively large sample size, we determined the plasma levels of the two neuropeptides in 85 normal children, 84 children with ASD, and 31 mothers from each group of *** expected, children with ASD had lower plasma OXT levels than gender-matched controls（P = 0.028）. No such difference was found for plasma AVP concentrations. Correlation analysis showed that ASD children with higher plasma OXT concentrations tended to have less impairment of verbal communication（Rho =-0.22,P = 0.076）, while those with higher plasma AVP levels tended to have lower levels of repetitive use of objects（Rho =-0.231, P = 0.079）. Unlike the findings in children, maternal plasma OXT levels showed no group difference. However, plasma AVP levels in the mothers of ASD children tended to be lower than in the mothers of normal children（P = 0.072）. In conclusion, our results suggest that the OXT system is dysregulated in children with ASD, and that OXT and AVP levels in plasma seem to be associated with specific autistic symptoms. The plasma levels of OXT or AVP in mothers and their ASD children did not seem to change in the same direction.

关键词： autism spectrum disorder oxytocin vasopressin behavioral relevance

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