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Auditory rehabilitation in Rhesus Macaque Monkeys （Macaca mulatta） with Auditory Brainstem Implants

Chinese Medical Journal 2015年第10期128卷 1363-1369页

作者： Zhen-Min Wang Zhi-Jun Yang Fu Zhao Bo Wang Xing-Chao Wang Pei-Ran Qu Pi-Nan Liu Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Neural Reconstruction Beijing Neurosurgical Institute Beijing 100050 China

Background：The auditory brainstem implants （ABIs） have been used to treat deafness for patients with neurofibromatosis Type 2 and nontumor *** lack of an appropriate animal model has limited the study of improving hearing rehabilitation by the *** study aimed to establish an animal model of ABI in adult rhesus macaque monkey （Macaca mulatta）.Methods：Six adult rhesus macaque monkeys （***） were *** general anesthesia,a multichannel ABI was implanted into the lateral recess of the fourth ventricle through the modified suboccipital-retrosigmoid （RS） *** electrical auditory brainstem response （EABR） waves were tested to ensure the optimal implant *** the operation,the EABR and computed tomography （CT） were used to test and verify the effectiveness via electrophysiology and anatomy,*** subjects underwent behavioral observation for 6 months,and the postoperative EABR was tested every two weeks from the 1st month after implant ***：The implant surgery lasted an average of 5.2 h,and no monkey died or *** averaged latencies of peaks Ⅰ,Ⅱ and Ⅳ were 1.27,2.34 and 3.98 ms,respectively in the ***-peak EABR wave was elicited in the operation,and one-or two-peak waves were elicited during the postoperative *** EABR wave latencies appeared to be constant under different stimulus intensities;however,the amplitudes increased as the stimulus increased within a certain ***：It is feasible and safe to implant ABIs in rhesus macaque monkeys （***） through a modified suboccipital RS approach,and EABR and CT are valid tools for animal model *** addition,this model should be an appropriate animal model for the electrophysiological and behavioral study of rhesus macaque monkey with ABI.

关键词： Animal Model Auditory Brain Stem Implants aural rehabilitation Feasibility Studies Macaca mulatta

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