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Journal of Otology 2014年第1期9卷 27-29页

作者： CHEN Aiting LIANG Sichao ZHANG Ruining GUO Weiwei ZHOU Qiyou JI Fei Department of Otolaryngology Head & Neck Surgery Chinese PLA General Hospital Chinese PLA Institute of Otolaryngology

Objective To analyze the characteristics of auditory brainstem response (ABR) in presbycusis patients el-der than 90 years. Methods Fourteen presbycusis patients elder than 90 years (presbycusis group, 91.1.4 ± 1.3 years, 26 ears) and 9 normal-hearing young adults (control group, 22.7 ± 1.2 years, 18 ears) participated in the study. Alternative click-evoked ABRs were recorded in both groups. The peak latency (PL) of peak I,Ⅲ, and V, and the inter-peak latency (IPI) of I-Ⅲ,Ⅲ-V, and I-V were compared between groups. Results In elder presbycusis patients, the occurrence rate of peak I andⅢwere both 76.9%, and that of peak V was 84.6%. In presbycusis group, the peak latencies of I, Ⅲ, V were significantly longer than that of control group (Pauditory brainstem responses in presbycusis pa-tients elder than 90 years showed worse wave differentiation.

关键词： auditory brainstem response auditory electrophysiology Presbycusis Senile patients

Universal newborn hearing screening program in Saudi Arabia: Current insight

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Journal of Otology 2024年第1期19卷 35-39页

作者： Noura Alothman Reem Elbeltagy Reem Mulla Department of Health Communication Sciences College of Health and Rehabilitation SciencesPrincess Nourah bint Abdulrahman UniversityRiyadhSaudi Arabia Audiovestibular Medicine Ear-Nose-Throat DepartmentFaculty of MedicineZagazig UniversityZagazigEgypt Department of Hearing Speech and Language SciencesGallaudet UniversityWashingtonDCUSA

Newborn hearing screening(NHS) programs are essential to identify hearing loss early in life and to improve outcomes in children. In Saudi Arabia, the national NHS program has been operational since 2016;however, few studies have evaluated its status, and none have covered all provinces across the country. This cross-sectional retrospective study provides an overview of the program's status across all provinces, focusing on screening coverage rates, referral/fail rates, and follow-up procedures. In 2021, 199,034 newborns were screened, with a coverage rate of 92.6% and an overall referral/fail rate of 1.87%. These performance measures provide a foundation for future progress and improvements. This study highlights the importance of ongoing efforts to enhance the program's effectiveness and sustainability.

关键词： Hearing screening Hearing loss Newborn auditory brainstem response Saudi Arabia

Effects of glutamate on distortion-product otoacoustic emissions and auditory brainstem responses in guinea pigs

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Journal of Otology 2008年第1期3卷 29-34页

作者： SUN Qing1,SUN Jian-he1,SHAN Xi-zheng2, LI Xing-qi1 1 Institute of Otorhinolaryngology, Chinese PLA General Hospital, Beijing 100853, China 2 Department of Otorhinolaryngology, General Hospital of Chinese People’s Armed Forces Beijing 100039, China Institute of Otorhinolaryngology Chinese PLA General Hospital Beijing 100853 China Department of Otorhinolaryngology General Hospital of Chinese People's Armed Forces Beijing 100039 China

Objectives To investigate changes in evoked potentials and structure of the guinea pig cochleae during whole cochlear perfusion with glutamate. Methods CM, CAP, DPOAE, and ABR were recorded as indicators of cochlear functions during whole cochlear perfusion. The morphology of the cochlea was studied via transmission electron microscopy. Results There were no significant changes in DPOAE amplitude before and after glutamate perfusion. CM I/O function remained nonlinear during perfusion. ABR latencies were delayed following glutamate perfusion. The average CAP threshold was elevated 35 dB SPL following glutamate perfusion.. The OHCs appeared normal, but the IHCs and afferent dendrites showed cytoplasmic blebs after glutamate perfusion. Conclusions While being a primary amino acid neurotransmitter at the synapses between hair cells and spiral ganglion neurons, excessive glutamate is neurotoxic and can destroy IHCs and spiral ganglion neurons. The technique used in this study can also be used to build an animal model of auditory neuropathy.

关键词： glutamate distortion product otoacoustic emission auditory brainstem response auditory neuropathy

A preliminary study of the mechanism of compound hearing loss caused by ototoxic drugs combined with impulse noise

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iLABMED 2024年第1期2卷 38-52页

作者： Xin Qiu Qing‐qing Jiang Wei‐wei Guo Ning Yu Shi‐ming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Chinese PLA Medical School BeijingChina

Background:Hearing loss(HL)is becoming increasingly common and is more commonly caused by noise,ototoxic substances,or a combination of ototoxic ***,so far,few studies have examined the mechanism by which compound factors cause *** only relevant study is about occupational ototoxic substances combined with environmental noise at 85-110 dB *** this study,to address the shortcomings of existing research,we innovatively focused on HL induced by loud noise(impulse noise,>160 dB SPL)combined with common ototoxic *** aim of this study was to establish and validate a mature animal model,and then to compare the characteristics of audiology,pathomorphology and molecular features,and to preliminarily predict pathogenesis in compound *** and Methods:We selected guinea pigs to construct in vivo HL model groups for different extents of exposure,including a blank control group,a single-drug group,a single-impulse noise group,and a compound *** animal model of the mature compound HL group was established using gentamicin combined with impulse *** then performed audio-logical and pathological *** analyzed the auditory brainstem response(ABR),pathological morphology of the cochlea,and molecules(including important self-radicals,cytokines,and apoptosis signal trans-duction pathway proteins in the pathogenesis of drug-and noise-induced HL),compared the effect of different extents of exposure on HL,and preliminarily predict the pathogenic mechanism of compound ***:Four groups of animal models were established successfully and verified by audiology and *** audiology,there were no sig-nificant differences in the ABR thresholds before exposure(p>0.05),but differences emerged among the groups after ***,after 3,7,and 14 days of exposure,there were significant differences in the ABR thresholds between the compound group and both the drug and noise groups(p<0.01),and after 14 days,the HL of the compoun

关键词： auditory brainstem response gentamicin hearing loss impulse noise molecular mechanisms pathomorphology

Circadian Rhythm and Intersexual Differences in auditory Frequency Sensitivity in Emei Music Frogs

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Asian Herpetological Research 2022年第1期13卷 43-52页

作者： Bicheng ZHU Xiaoqian SUN Haodi ZHANG Yezhong TANG Jianguo CUI CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan ProvinceChengdu Institute of BiologyChinese Academy of SciencesChengdu 610041SichuanChina University of Chinese Academy of Sciences Beijing 100049China

In anurans, calling behaviour is strongly seasonal and circadian. Previous studies have revealed that a uditory sensitivity in frogs exhibits seasonal plasticity, and electroencephalographic signals exhibit highly correlated circadian patterns;of which, the circadian rhythm remains unknown. In this study,the circadian rhythm and intersexual differences of auditory sensitivity were tested in the Emei music frog(Nidirana daunchina). This was achieved by comparing thresholds and latencies of auditory brainstem responses(ABRs) evoked by tones and clicks stimuli between male and female frogs during the day and at night,respectively. Our results revealed that both auditory thresholds and latencies had no differences between day and night except the la tencies in 3.5–4.0 kHz frequencies. However, the thresholds of tone pip evoked ABRs differed significantly between male and female frogs from 2.5 to 5.0 kHz. This demonstrated that the auditory sensitivity of Emei music frogs exhibits sexual dimorphism at high frequencies, with female frogs exhibiting greater auditory sensitivity than that of male frogs. Simultaneously, the power spectra of male advertisement calls are matched well with the frequency range of auditory sensitivity in male and female frogs,which supports the matched filter hypothesis. Our study enhances the understanding of circadian plasticity and sexual dimorphism of auditory sensitivity in frogs.

关键词： auditory brainstem response auditory plasticity day-night rhythm frog sexual auditory dimorphism the matched filter hypothesis

THE EFFECTS OF SALICYLATE ON auditory EVOKED POTENTIAL AMPLITWDE FROM THE auditory CORTEX AND auditory brainstem

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Journal of Otology 2014年第1期9卷 30-35页

作者： Brian Sawka SUN Wei Center for Hearing & Deafness Department of Communicative Disorders and Sciences State University of New York at Buffalo

Tinnitus has often been studied using salicylate in animal models as they are capable of inducing tempo-rary hearing loss and tinnitus. Studies have recently observed enhancement of auditory evoked responses of the auditory cortex (AC) post salicylate treatment which is also shown to be related to tinnitus like behavior in rats. The aim of this study was to observe if enhancements of the AC post salicylate treatment are also present at structures in the brainstem. Four male Sprague Dawley rats with AC implanted electrodes were tested for both AC and auditory brainstem response (ABR) recordings pre and post 250 mg/kg intraperitone-al injections of salicylate. The responses were recorded as the peak to trough amplitudes of P1-N1 (AC), ABR wave V, and ABR waveⅡ. AC responses resulted in statistically significant enhancement of ampli-tude at 2 hours post salicylate with 90 dB stimuli tone bursts of 4, 8, 12, and 20 kHz. Wave V of ABR re-sponses at 90 dB resulted in a statistically significant reduction of amplitude 2 hours post salicylate and a mean decrease of amplitude of 31%for 16 kHz. WaveⅡamplitudes at 2 hours post treatment were signifi-cantly reduced for 4, 12, and 20 kHz stimuli at 90 dB SPL. Our results suggest that the enhancement chang-es of the AC related to salicylate induced tinnitus are generated superior to the level of the inferior colliculus and may originate in the AC.

关键词： Salicylate Tinnitus auditory brainstem response

Calpain mediated cisplatin-induced ototoxicity in mice

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Neural Regeneration Research 2013年第21期8卷 1995-2002页

作者： Liang Chang Aimei Wang Party and Government Affairs Office Jinzhou Central Hospital Department of Physiology Liaoning Medical University

Ototoxic drug-induced apoptosis of inner ear cells has been shown to be associated with calpain expression. Cisplatin has severe ototoxicity, and can induce cochlear cell apoptosis. This study assumed that cisplatin activated calpain expression in apoptotic cochlear cells. A mouse model of cisplatin-induced ototoxicity was established by intraperitoneal injection with cisplatin （2.5, 3.5, 4.5, 5.5 mg/kg）. Immunofluorescence staining, image analysis and western blotting were used to detect the expression of calpain 1 and calpain 2 in the mouse cochlea. At the same time, the auditory brainstem response was measured to observe the change in hearing. Results revealed that after intraperitoneal injection with cisplatin for 5 days, the auditory brainstem response threshold shifts increased in mice. Calpain 1 and calpain 2 expression significantly increased in outer hair cells, the spiral ganglion and stria vascularis. Calpain 2 protein expression markedly increased with an increased dose of cisplatin. Results suggested that calpain 1 and calpain 2 mediated cisplatin-induced ototoxicity in BALB/c mice. During this process, calpain 2 plays a leading role.

关键词： neural regeneration biological factor cisplatin mice cochlea apoptosis calpain auditory brainstem response ototoxicity immunofluorescence staining image analysis technique western blotting grants-supported paper neuroregeneration

Mechanism of alpha-lipoic acid in attenuating kanamycin-induced ototoxicity

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Neural Regeneration Research 2012年第35期7卷 2793-2800页

作者： Aimei Wang Ning Hou Dongyan Bao Shuangyue Liu Tao Xu Department of Physiology Liaoning Medical University Scientific Laboratorial Center Liaoning Medical University

In view of the theory that alpha-lipoic acid effectively prevents cochlear cells from injury caused by various factors such as cisplatin and noise, this study examined whether alpha-lipoic acid can prevent kanamycin-induced ototoxicity. To this end, healthy BALB/c mice were injected subcutaneously with alpha-lipoic acid and kanamycin for 14 days. auditory brainstem response test showed that increased auditory brainstem response threshold shifts caused by kanamycin were significantly inhibited. Immunohistochemical staining and western blot analysis showed that the expression of phosphorylated p38 mitogen-activated protein kinase and phosphorylated c-Jun N-terminal kinase in mouse cochlea was significantly decreased. The experimental findings suggest that phosphorylated p38 and phosphorylated c-Jun N-terminal kinase mediated kanamycin-induced ototoxic injury in BALB/c mice. AIpha-lipoic acid effectively attenuated kanamycin ototoxicity by inhibiting the kanamycin-induced high expression of phosphorylated p38 and phosphorylated c-Jun N-terminal kinase.

关键词： alpha-lipoic acid kanamycin mouse cochlea p38 mitogen-activated protein kinase c-JunN-terminal kinase auditory brainstem response phosphorylation hearing loss western blot immunohistochemistry

Neurophysiological characteristics in infants and young children with auditory neuropathy

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Journal of Nanjing Medical University 2005年第1期19卷 25-29页

作者： GuangqianXing XingkuanBu DengyuanWang LingLu DepartmentofOtorhinolaryngology theFirstAffiliatedHospitalofNanjingMedicalUniversityNaning210029China

Objective:To analyze neurophysiological characteristics in infants and young children with auditory neuropathy(AN) and explore their clinical ***: Audiological measurements(acoustic immittance, EOAEs, ABR, CM, MLR and ERPs) and peripheral neurological tests were conducted and evaluated in 13 infants and young children with AN. Six of them received high-resolution temporal bone CT scans and/or cerebral MRI ***: All of the children showed type “A” tympanograms with abseatation of stapedial reflexes. EOAEs were normal in 12 of 13 subjects. In one child who had a history of anoxia during the birth,the EOAEs were not elicited. Click-evoked ABRs were absent in 12 of 13 subjects when maximum output of the instrument was reached. The CM potentials were presented bilaterally in all individuals,which were independent of the EOAEs and ABR. Of eight cases tested,all had clear MLR and six showed normal ERPs(P300 and MMN). Peripheral neurological tests and radiological findings were within the normal ranges. Conclusion: The diagnosis of AN in infants and young children should focus on analyzing their neurophysiological characteristics,especially on CM,MLR and ERPs. Combined use of EOAEs, ABR and CM was recommended for hearing screening on newborns with high risk factors.

关键词： auditory neuropathy auditory brainstem response otoacoustic emissions hearing screening