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Novel multi-parametric diagnosis of non-alcoholic fatty liver disease using ultrasonography,body mass index,and Fib-4 index

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World Journal of Gastroenterology 2023年第23期29卷 3703-3714页

作者： Kei Funada Yumi Kusano Yoshinori Gyotoku Ryosaku Shirahashi Toshikuni Suda Masaya Tamano Department of Gastroenterology Dokkyo Medical University Saitama Medical CenterKoshigaya-shi 343-8555SaitamaJapan

BACKGROUND Shear wave speed(SWS),shear wave dispersion(SWD),and attenuation imaging(ATI)are new diagnostic parameters for non-alcoholic fatty liver *** differentiate between non-alcoholic steatohepatitis(NASH)and non-alcoholic fatty liver(NAFL),we developed a clinical index we refer to as the“NASH pentagon”consisting of the 3 abovementioned parameters,body mass index(BMI),and Fib-4 *** To investigate whether the area of the NASH pentagon we propose is useful in discriminating between NASH and *** This non-invasive,prospective,observational study included patients diagnosed with fatty liver by abdominal ultrasound between September 2021 and August 2022 in whom shear wave elastography,SWD,and ATI were *** diagnosis based on liver biopsy was performed in 31 *** large pentagon group(LP group)and the small pentagon group(SP group),using an area of 100 as the cutoff,were compared;the NASH diagnosis rate was also *** patients with a histologically confirmed diagnosis,receiveroperating characteristic(ROC)curve analyses were *** One hundred-seven patients(61 men,46 women;mean age 55.1 years;mean BMI 26.8 kg/m2)were *** LP group was significantly older(mean age:60.8±15.2 years vs 46.4±13.2 years;P<0.0001).Twenty-five patients who underwent liver biopsies were diagnosed with NASH,and 6 were diagnosed with *** ROC curve analyses,the areas under the ROC curves for SWS,dispersion slope,ATI value,BMI,Fib-4 index,and the area of the NASH pentagon were 0.88000,0.82000,0.58730,0.63000,0.59333,and 0.93651,respectively;the largest was that for the area of the NASH *** The NASH pentagon area appears useful for discriminating between patients with NASH and those with NAFL.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis attenuation imaging Shear wave elastography Shear wave dispersion Diagnosis

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Advances in diagnostic ultrasound techniques for assessing liver steatosis in nonalcoholic fatty liver disease

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iLIVER 2023年第4期2卷 214-218页

作者： Zhaoxin Wang Yarong Ma Xiaolei Wu Yingxin Lu Qiuyun She Beijing University of Chinese Medicine Beijing 100029China Tianjin University of Traditional Chinese Medicine Tianjin 301617China Dongguan Hospital of Traditional Chinese Medicine Dongguan 523000China Caoyang Street Community Health Service Center of Shanghai City Shanghai 200062China

The incidence of nonalcoholic fatty liver disease(NAFLD),a common chronic liver disease,is increasing *** increasing degrees of liver steatosis,NAFLD can progress to varying degrees of hepatic fibrosis,cirrhosis,and even hepatocellular carcinoma(HCC),with a concomitant increase in the risk of metabolic syndrome and cardiovascular ***,early diagnosis and accurate assessment of NAFLD are particularly *** liver biopsy is regarded as the standard for evaluating the degree of hepatic steatosis in NAFLD,it is not frequently utilized due to its *** technology as a noninvasive diagnostic method has the advantages of operating simplicity and *** can effectively diagnose and assess the disease of *** article mainly summarizes the current status and progress of research on the assessment of NAFLD and liver steatosis by two main types of ultrasound techniques,semi-quantitative and quantitative ultrasound,as well as other emerging techniques,and briefly describes the strengths and limitations of B-mode ultrasound,controlled attenuation parameters(CAP),and attenuation imaging(ATI)in this field.

关键词： Nonalcoholic fatty liver disease Hepatic steatosis Ultrasound technology Controlled attenuation parameters attenuation imaging

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