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atractylenolide ⅰ protects against lipopolysaccharide-induced disseminated intravascular coagulation by anti-inflammatory and anticoagulation effect

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Asian Pacific Journal of Tropical Medicine 2017年第6期10卷 651-657页

作者： Xiao-Mei Tang Zhi-Kai Liao You-Wei Huang Xi Lin Liang-Cai Wu Department of Obstetrics and Gynecology The First Affiliated Hospital of Jinan University Department of Pharmacology Medical College Jinan University Department of Dermatology The 6th Affiliated Hospital Sun Yat-sen University

Objective:To investigate whether atractylenolide ⅰ(ATL-Ⅰ) has protective effect on lipopolysaccharide(LPS)-induced disseminated intravascular coagulation(DIC) in vivo and in vitro,and explore whether NF-κB signaling pathway is involved in ATL-Ⅰ ***:New Zealand white rabbits were injected with LPS through marginal ear vein over a period of 6h at a rate of 600 μg/kg(10 mL/h).Similarly,in the treatment groups,1.0,2.0,or 5.0 mg/kg ATL-Ⅰ were *** survival rate and organ function were tested,including the level of alanine aminotransferase(ALT),blood urine nitrogen(BUN),and TNF-α were examined by *** haemostatic and fibrinolytic parameters in serum were *** 264.7 macrophage cells were administered with control,LPS,LPS + ATL-Ⅰ and ATL-Ⅰ alone,and TNF-α,phosphorylation(P)-IκBα,phosphorylation(P)-NF-κB(P65) and NF-κB(P65) were determined by Western ***:The administration of LPS resulted in 73.3%mortality rate,and the increase of serum TNF-α,BUN and ALT *** ATL-Ⅰ treatment significantly increased the survival rate of LPS-induced DIC model,also improved the function of blood *** protein analysis indicated that ATL-Ⅰ remarkably protected liver and renal as decreasing TNF-α *** vitro,ATL-Ⅰ obviously decreased LPS-induced TNF-αproduction and the expression of P-NF-κB(P65),with the decrease of P-IκBα.Conclusions:ATL-Ⅰ has protective effect on LPS-induced DIC,which can elevate the survival rate,reduce organ damage,improve the function of blood coagulation and suppress TNF-α expression by inhibiting the activation of NF-κB signaling pathway.

关键词： atractylenolide ⅰ Disseminated intravascular coagulation Anti-inflammatory Anticoagulation Macrophag

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