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HDL quality features revealed by proteome–lipidome connectivity are associated with atherosclerotic disease

Journal of Molecular Cell Biology 2022年第3期14卷 12-22页

作者： Dandan Wang Bilian Yu Qingrun Li Yanhong Guo Tomonari Koike Yui Koike Qingqing Wu Jifeng Zhang Ling Mao Xiaoyu Tang Liang Sun Xu Lin Jiarui Wu Y.Eugene Chen Daoquan Peng Rong Zeng CAS Key Laboratory of Systems Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China Department of Cardiovascular Medicine the Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of Internal Medicine Cardiovascular CenterUniversity of Michigan Medical CenterAnn ArborMI 48109USA Key Laboratory of Nutrition and Metabolism Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Systems Biology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesChinese Academy of SciencesHangzhou 310024China

Lipoprotein,especially high-density lipoprotein(HDL),particles are composed of multiple heterogeneous subgroups containing various proteins and *** molecular distribution among these subgroups is closely related to cardiovascular disease(CVD).Here,we established high-resolution proteomics and lipidomics(HiPL)methods to depict the molecular profiles across lipoprotein(Lipo-HiPL)and HDL(HDL-HiPL)subgroups by optimizing the resolution of anion-exchange chromatography and comprehensive quantification of proteins and lipids on the omics ***,based on the Pearson correlation coefficient analysis of molecular profiles across high-resolution subgroups,we achieved the relationship of proteome–lipidome connectivity(PLC)for lipoprotein and HDL *** application of these methods to high-fat,high-cholesterol diet-fed rabbits and acute coronary syndrome(ACS)patients,we uncovered the delicate dynamics of the molecular profile and reconstruction of lipoprotein and HDL *** note,the PLC features revealed by the HDL-HiPL method discriminated ACS from healthy individuals better than direct proteome and lipidome quantification or PLC features revealed by the Lipo-HiPL method,suggesting their potential in ACS ***,we established HiPL methods to trace the dynamics of the molecular profile and PLC of lipoprotein and even HDL during the development of CVD.

关键词： HDL high resolution proteomics lipidomics atherosclerotic disease

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Leriche syndrome with coronary artery disease and lower limb gangrene:two case reports

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Journal of Coastal Life Medicine 2016年第6期4卷 500-501页

作者： Ana Manuel Lute Silva Domingas Baiao Telmo Martins Cardio-Thoracic Center Girassol ClinicAvenida Comandante GikaNo.255LuandaAngola

Leriche syndrome is characterized by atheromatous occlusion of the infrarenal aorta,common iliac arteries or *** the epidemiological transition recently observed in some low/middle income countries,primary prevention of peripheral arterial disease progression is of utmost *** described two cases of severe leriche syndrome in clinical situations of high complexity with fatal *** simultaneous presence of clinically relevant atherosclerotic lesions in two major vascular territories,requires attention not only on lesion sites and inherent invasive procedures technical difficulties,but also on the cardiovascular risk factors and *** remarkable feature is the existence of diffuse atherosclerosis and comorbidities whose severity conditioned deference and complications of the vascular lesion *** syndrome has an important impact on cardiovascular and overall *** case report highlights the need of re-thinking established approach to atherosclerotic disease,especially in countries with limited resources.

关键词： Leriche syndrome atherosclerotic disease Coronary artery disease Limb gangrene Angola

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患勃起功能障碍的男性应该检查其心血管问题吗？

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Asian Journal of Andrology 2012年第1期14卷 138-144,179页

作者： Kenneth A Ewane Hao-Cheng Lin Run Wang Division of Urology University of Texas Medical School at Houston Houston TX 77030 USA Department of Urology Affiliated Drum Tower Hospital Nanjing University School of Medicine Nanjing 210008 China Department of Urology University of Texas M D Anderson Cancer Center Houston TX 77030 USA

The landmark Massachusetts Male Ageing Study shed new light on the prevalence of erectile dysfunction （ED） and drew attention to ED as a disease of ageing. Over the years, ED has been linked to the development of cardiovascular disease （CVD） in some patients. There is clear evidence that ED and CVD share and have a similar risk factor profile. CVD is one of the most recognizable causes of mortality and early detection coupled with prevention of mortality from CVD has been the prime interest of many researchers. Consequently, there has been a multidisciplinary curiosity regarding the proposal to use ED as a marker for future CVD. I n fact, there have been several proposals to use ED as a screening tool for future CVD. We performed a comprehensive Search of two main databases--PubMed and Cochrane Library using a combination of keywords such as acute myocardial infarction, coronary artery disease （CAD） and ED. Journal articles from January 2000 to June 2011 were reviewed. We included all articles discussing the relationship between ED and CVD in the English language. All the relevant randomized controlled trials, cohort and retrospective studies, and review articles were included in our overall analysis in an attempt to answer the question whether all patients with ED should be clinically evaluated for CVD. The results showed a link between ED and the development of future CVD in some patients, but ED was not shown to be an independent risk predictor that is any better than the traditional Framingham risk factors. Screening for CVD may, however, be rewarding in younger patients with severe ED and in patients with concurrent CVD risk factors.

关键词： atherosclerotic disease cardiovascular disease coronary artery disease erectile dysfunction

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