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Assessment of co-segregated TLR4 genotypes among Nigerian children with asymptomatic and clinical malaria

Asian Pacific Journal of Tropical Biomedicine 2017年第2期7卷 96-102页

作者： Bamidele Abiodun Iwalokun Senapon Olusola Iwalokun Bernice Enobong Udoh Modinat Balogun Molecular Biology and Biotechnology Division Nigerian Institute of Medical ResearchLagosNigeria Olorunda Primary Health Centre LagosNigeria Department of Medical Microbiology and Parasitology Olabisi Onabanjo UniversityOgun StateNigeria Iru Primary Health Centre LagosNigeria

Objective: To assess the occurrence and pattern of Toll-like receptor 4(TLR4) cosegregated genotypes among children with Plasmodium falciparum malaria in ***: In this case-control study, a total of 79 Plasmodium falciparum infected children aged 2–7 years and 105 age-matched uninfected controls of Yoruba descents in Lagos were studied. The extracted DNA samples were used for TLR4 genotyping at codons 299(Asp > Gly) and 399(Thr > Ile) by PCR-restriction fragment length polymorphism. malaria infection was diagnosed by blood smear microscopy and infected children were stratified into asymptomatic, uncomplicated and severe malaria *** was determined by measuring the mid upper arm circumference and anemia was defined as hemoglobin 0.05) in frequency between infected and non-infected children. However, low and high occurrences of the TLR4 Asp299Asp/Thr399 Thr and Asp299Gly/Thr399 Thr genotypes were observed in the severe malaria ***: This study reveals a protective role for TLR4 Asp299Gly/Thr399 Ile and Asp299Asp/Thr399 Thr genotypes against severe malaria in Nigerian children.

关键词： TLR4 polymorphism TLR4 co-segregated genotypes asymptomatic malaria Clinical malaria Nigeria

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