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astragalin attenuates diabetic cataracts via inhibiting aldose reductase activity in rats

International Journal of Ophthalmology(English edition) 2023年第8期16卷 1186-1195页

作者： Na Wang Deepika Singh Qiong Wu Department of Ophthalmology Shaanxi Eye HospitalXi’an People’s Hospital(Xi’an Fourth Hospital)Affiliated People’s Hospital of Northwest UniversityXi’an 710004Shaanxi ProvinceChina Department of Pharmaceutical Sciences Sam Higginbottom University of AgricultureTechnology and SciencesPrayagraj 211007India

AIM:To investigate the aldose reductase(AR)inhibition capacity of astragalin(AST)against streptozoticin-induced diabetic cataracts(DCs)in ***:Ex vivo investigations were conducted by treating the lens of a goat placed for 72h in artificial aqueous humor(AAH)of pH 7.8 at room temperature with cataract-causing substance(55 mmol/L of galactose)and in vivo studies were performed on rats via induction with *** was administered at different dose levels and scrutinize for DC ***:In diabetic rats,AST improved the body weight,blood insulin,and glucose as well as the levels of galactitol in a dose-dependent way,other biochemical parameters *** mediators and cytokines,and also suppress AR *** level of the antioxidant parameters such as superoxide dismutase(SOD),catalase(CAT),and glutathione(GSH)activity were also altered on a diabetic lens after the administration of the ***:AST protects against lens opacification to avoid cataracts and polyols formation,indicating that it could be used as a potential therapeutic agent for diabetes.

关键词： astragalin diabetic cataract lens opacification aldose reductase rats

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astragalin and rutin restore gut microbiota dysbiosis, alleviate obesity and insulin resistance in high-fat diet-fed C57BL/6J mice

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Food Science and Human Wellness 2024年第6期13卷 3256-3265页

作者： Muni Swamy Ganjayi Karunakaran Reddy Sankaran Balaji Meriga Ruchika Bhatia Shikha Sharma Kanthi Kiran Kondepudi Department of Biochemistry Sri Venkateswara UniversityTirupati 517502India Department of Biomedical Sciences Heritage College of Osteopathic MedicineOhio UniversityAthens 45701United States Food and Nutrition Biotechnology Division National Agri-Food Biotechnology InstituteSAS NagarPunjab 140306India

In the present study we investigated the impact of the combination of astragalin and rutin(CAR)on restoring gut-microbial dysbiosis and obesity and obesity related *** male C57BL/6J mice were experimentally divided into 5 groups and fed either a normal diet or a high-fat diet(HFD)for 16 *** to vehicle treated group(HFD group),CAR could substantially improve selected gut microbiota abundance(Akkermansia,Lactobacillus,Bifidobacteria,Roseburia,Prevotella),reversed the Firmicutes/Bacteroidetes proportions,and inhibited the growth of Escherichia coli,Salmonella,and Klebsiella in obese *** addition,CAR-treated mice showed significantly increased total short-chain fatty acid production,reduced body weight gain,organs’weights,serum lipid profile(except HDL)and insulin *** mRNA expressions of CCAAT/enhancer binding protein-α(C/EBP-α),sterol regulatory element-binding protein-1c(SREBP-1c),peroxisome proliferator-activated receptor-γ(PPAR-γ),acetyl-CoA carboxylase(ACC),adipocyte protein 2(aP2),and fatty acid synthase(FAS)were downregulated(P<0.05)and the protein expression of PPAR-γwas downregulated while adenosine 5’monophosphate-activated protein kinase(AMPK)was phosphorylated in CAR-treated HFD-fed mice compared to the HFD control ***,CAR-treated HFD-fed mice showed significantly improved tissue architecture in the liver and fatty *** conclusion,the findings suggest that CAR/Moringa oleifera may be beneficial in the treatment of insulin resistance and obesity disorders.

关键词： astragalin Gut microbiota Moringa oleifera Obesity Rutin

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Effect of astragalin on matrix secretion and β1 integrin mRNA expression in human mesangial cells

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Chinese Medical Journal 1999年第12期 7-11页

作者：倪兆慧张庆怡钱家麒王利民

Objective To investigate the effect of astragalin on human renal mesangial cells Methods Cultured human mesangial cells were treated with astragalin and astragalin serum in different concentrations in the presence or absence of PDGF BB, the proliferation and type Ⅳ collagen secretion of mesangial cells were measured by MTT assay and ELISA, and expression of β1 integrin gene was estimated by reverse transcription polymerase chain reaction (RT PCR) method, sespectively Results After 72 hours astragalin or astragalin serum treatment, the proliferation of mesangial cells induced by PDGF BB was inhibited significantly in a dose dependent manner compared with untreated controls ( P astragalin or astragalin serum treatment, the secretion of type Ⅳ collagen protein in presence of PDGF BB was significantly decreased and β1 integrin mRNA level decreased significantly compared with untreated control ( P astragalin inhibits cell proliferation and matrix over synthesis which might be mediated, at least, partly by decrease of β1 integrin gene over expression The study suggested that astragalin might play a role in preventing the progression of chronic renal diseases

关键词： astragalin mesangial cell β1 integrin type Ⅳ collagen

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Effect of astragalin on Paraoxon-induced Vascular Endothelium Dysfunction

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Plant Diseases and Pests 2011年第2期2卷 73-76页

作者：李鹏尹雅玲潘国聘赵繁荣王倩倩新乡医学院医学院河南新乡453003 新乡医学院基础医学院河南新乡453003

[ Objective] The paper was to explore the effect of astragalin on paraoxon-indueed vascular endothelium dysfunction and analyze the potential mecha- nism. [Method]The isolated rat thoracic aorta rings were exposed to medium contained paraoxon （3.63 μmol/L）, and astragalin （10 μmol/L） was used to inhib- it the damage effect. Rat thoracic aorta rings were suspended in organ chambers to assess vas orelaxation activity in vitro by acetyleholine （ACh）-induced endotheli- um dependent relaxation reaction （EDRR） and sodium nitroprusside （SNP）-induced endothdium-independent relaxation reaction. [Result]The exposure to parao- xon （3.63 μmol/L） resulted in an inhibition of the EDRR, markedly reduced the level of nitric oxide （NO）, the activity of paraoxonasel （PON1） and superoxide dismutase （SOD）, and significantly increased the level of malondialdehyde （MDA） in isolated rat thoracic aorta. However, the presence of astragalin （10 μmol/L） markedly attenuated the vascular endothelium dysfunction induced by paraoxon via increasing level of NO, activity of PON1 and SOD, as well as reducing level of MDA. In addition, treatment of astragalin （ 10 μmol/L） showed a similar effect to hydrogen peroxide （ 1.0 μmol/L）, a kind of antioxidant, on paraoxon- induced vascular endothelium dysfunction. [ Conclusion] astragalin could protect the vascular endothelium against the paraoxon-induced dysfunction in isolated rat thoracic aorta, and＇the beneficial effects of astragalin might be concerned with the antioxidation of astragalin due to inhibiting the decreased activity of PONI.

关键词： astragalin Paraoxon Oxidative stress Paraoxonase 1

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Quantitative Metabolomics:Analysis on Active Components in Extracts from Kaki Folium

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Chinese Herbal Medicines 2012年第4期4卷 276-281页

作者： DAI Li-peng GU Yuan YIN Ren-jie LIU Chang-xiao SI Duan-yun State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical Research Tianjin 300193 China School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co. Ltd. Guangzhou 510515 China

Objective In order to analyze the active components in the extracts from Kaki Folium(KF),quantitative metabolomics approach was adopted to investigate the number of active components existing among the different extracts and their *** LC-MS method was established for the quantitative determination of the active components taking the mixture with reference substance as tested *** In terms of the number of active components and amount presented in the different tested samples of KF extracted by many types of solvents,variation was *** rutin,astragalin,and kaempferol were presented in all *** was found between the samples extracted from the products on market and from the raw materials of KF processed by polar solvents with different ***,the three active components were found in all samples *** These results might be valuable as all information and could be used for the optimization of raw materials extraction procedure to enhance the productivity.

关键词： active components astragalin extracts from Kaki Folium kaempferol metabolomics quantitative metabolomics rutin

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