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Adverse Events following astrazeneca COVID-19 Vaccination: A Case Study in Abidjan, Côte d’Ivoire

Open Journal of Immunology 2024年第2期14卷 11-15页

作者： Chiayé Claire Antoinette Yapo-Crezoit Samuel Boahene Mireille Dosso Immunity Biology Unit Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire

Introduction: Pharmaceutical companies have boosted vaccine production following the global COVID-19 pandemic. In Côte d’Ivoire, the first vaccination campaign with the astrazeneca vaccine began on March 1, 2021, as part of the Covax program. Despite the positive benefit/risk balance, the adverse effects of vaccination should not be minimized. Objective: To identify adverse events of astrazeneca’s COVID-19 vaccination for better management. Materials and Methods: This is a case of a 57-year-old obese (BMI = 39 kg/m2) female health care worker who experienced adverse events in March 2021 after the second dose of astrazeneca vaccine administered 4 weeks apart. These were subject to mandatory case reporting. Results: Major post-vaccination events occurred in a noisy systemic picture with parameters showing significant disturbances. Biological surveillance remains costly and makes the accountability of the vaccine complex. Conclusion: Vaccination remains the ultimate weapon in the fight against endemic diseases but should not overshadow the reporting of adverse events.

关键词： Adverse Events Post-Second Immunization astrazeneca vaccine Abidjan

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Down Protein C and S Antigen Could Be Predictor of Mortality Outcome in Critical Egyptian COVID-19 Illness

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Journal of Biosciences and Medicines 2022年第3期10卷 190-202页

作者： Nadia El Menshawy Ghada Elsaid Tarek Abo Zeid Nora A. Farag Clinical Pathology Department Hematology Unit Faculty of Medicine Oncology Center Mansoura University Mansoura Egypt Internal Medicine Specialized Medicine Hospital Mansoura University Mansoura Egypt Clinical Hematology Faculty of Medicine Oncology Center Mansoura University Mansoura Egypt Clinical Pathology Department Hematology Unit Faculty of Medicine Mansoura University Delta University Gamasa Egypt

Background: One of the most serious morbidity and mortality features in COVID-19 is thrombo-embolic manifestation with disturbed hemostasis in natural anticoagulant. Protein S plays a critical role in cytokine storming and acts as cross talk between immune status and coagulation process. So, we aimed to address its role in addition to protein C in severity and outcome of disease, with its role in vaccinated people by astrazeneca. Methods: The present study was conducted on 70 COVID-19 positive by real-time PCR. 40 of patients had moderate symptoms of respiratory, 30 cases were admitted into ICU of Mansoura University Hospital, some of them under mechanical ventilator. In addition to 40 healthy volunteers after first dose of vaccinated AstraZenka as reference, assessment of protein C&S antigen was done by ELIZA. Results: Significant increase in total leucocytic count in COVID-19 than vaccinated volunteer with significant reduction in absolute lymphocytosis, increased neutrophilia. First significant observation was higher MPV in COVID-19 than vaccinated, in addition to significantly higher C-reactive protein in severe cases than moderate and vaccinated. Prominent interesting finding in our study was significant reduction in Protein C&S in severe cases than moderate and vaccinated. Logistic regression analysis revealed that both could be predictor of mortality outcome as CRP in COVID-19 illness. Conclusion: There was significant reduction in protein C&S in severe cases than moderate and vaccinated. Regression analysis shows that could be predictor of mortality as well as CRP, D-dimer. Large extended study and follow up are needed to assess the incidence of thromboembolism and role of protein C&S in different variety protocols of vaccination programs.

关键词： Protein C S COVID-19 astrazeneca vaccine

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