检索结果-南通市图书馆

validity of studies suggesting preoperative chemotherapy for resectable thoracic esophageal cancer:A critical appraisal of randomized trials

引用

World Journal of Gastrointestinal Oncology 2020年第1期12卷 113-123页

作者： Giulia Manzini Ursula Klotz Doris Henne-Bruns Michael Kremer Department of General and Visceral Surgery University of UlmUlm 89081Germany Department of General and Visceral Surgery Hospital of AarauAarau 5000Switzerland

BACKGROUND In 2015,Kidane published a Cochrane review and meta-analysis to summarise the impact of preoperative chemotherapy versus surgery alone on survival for resectable thoracic esophageal *** authors concluded that preoperative chemotherapy improved overall survival(OS).AIM The aim of this article was to assess the validity of the three most powerful studies included in the Cochrane review and the meta-analysis supporting the advantage of preoperative chemotherapy and to investigate the impact of an exclusion of these three studies on the result of the *** OS was selected as the endpoint of *** the ten included papers which analysed this endpoint,we identified the three publications with the highest weights influencing the final *** validity of these papers was analysed using the CONSORT checklist for randomized controlled *** performed a new meta-analysis without the three studies to assess their impact on the general result of the original *** The three analysed studies revealed several *** answers were found in up to one third of the items of the CONSORT *** information about sample-size calculation and power,unclear or inadequate randomisation,and missing blinded set-up were the most common *** the three criticized studies were excluded in the meta-analysis,preoperative chemotherapy showed no benefit in *** The three most powerful publications in the Cochrane review show substantial *** the exclusion of these studies from the meta-analysis,preoperative chemotherapy does not seem to result in an advantage in *** suggest a more critical appraisal regarding the validity of single studies.

关键词： Esophageal cancer assessment of validity Meta-analysis CONSORT Overall survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：