检索结果-南通市图书馆

In vivo and in vitro antiproliferative and antimetastatic effects of hemolymph of aspongopus chinensis Dallas on breast cancer cells

引用

Journal of Traditional Chinese Medicine 2021年第4期41卷 523-529页

作者： ZHAO Shuai TAN Jun YU Hengmei TIAN Ying WU Youfang LUO Rui GUO Jianjun Institute of Entomology Guizhou Provincial Key Laboratory for Agricultural Pest Management in Mountainous RegionGuizhou UniversityGuiyang 550025China Institute of Entomology Guizhou UniversityGuizhou Provincial Key Laboratory for Agricultural Pest Management in Mountainous RegionGuiyang 550025China Department of Histology and Embryology Zunyi Medical UniversityZunyi 563000China College of Life Science Guizhou UniversityGuiyangGuizhou 550025China

OBJECTIVE:To investigate the effects of aspongopus(A.)chinensis hemolymph on the proliferation and metastasis of breast cancer ***:The in vitro effects of *** hemolymph were investigated in murine(4T1)and human(HCC1937)breast cancer cell ***,cell apoptosis,and cell migration were evaluated by using the cell counting kit-8 assay,Hoechst staining,and wound healing experiments,respectively.A syngeneic mouse model was established to evaluate the in vivo effects of the hemolymph extract on tumor growth and *** body weight,tumor size,blood levels of function-related enzymes,and pathological features of the liver and kidney tissues were ***:The hemolymph of *** significantly inhibited in vitro tumor cell migration and viability while inducing ***,it inhibited in vivo tumor growth and metastasis with a minimal effect on mouse body weight,and did not induce liver or kidney ***:Our results suggested that the *** hemolymph has antitumorigenic properties,suggesting it has potential as a novel therapeutic option for the treatment of metastatic breast cancer.

关键词： breast neoplasms cell proliferation neoplasm metastasis apoptosis aspongopus chinensis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asponchimides A−E: new enantiomeric N-acetyldopamine trimers from aspongopus chinensis

引用

Chinese Journal of Natural Medicines 2023年第11期21卷 859-867页

作者： NIE Jinchun MEI Fang ZHENG Yueyuan WEN Qiuyi LI Zhenwei ZHANG Daidi LI Wei GUO Dean School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshan 528400China

Five new racemic N-acetyldopamine (NADA) trimers, asponchimides A−E ( 1 − 5 ), were isolated from aspongopus chinensis, a prominent traditional Chinese medicinal insect employed for alleviating pain, treating indigestion, and addressing kidney ailments. Compounds 1 − 5 were successfully resolved by chiral high-performance liquid chromatography (HPLC), yielding five pairs of enantiomers: (+)- and (−)-asponchimides A−E ( 1a / 1b − 5a / 5b ). Their structural identities were discerned by extensive spectroscopic analyses, including high-resolution mass spectrometry (HRMS), ultraviolet-visible (UV-Vis) spectroscopy, infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR), and their absolute configurations were determined by electronic circular dichroism (ECD) calculations. Compounds 1 − 5 are pioneering instances of NADA trimers featuring a Δ7 double bond. When subjected to a series of bioassays, a majority of the compounds exhibited weak inhibitory activity against nitric oxide (NO) production in LPS-induced RAW 264.7 cells.

关键词： aspongopus chinensis N-acetyldopamine trimer ECD calculations NO inhibitory activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：