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HIV aspartyl protease inhibitors as promising compounds against Candida albicans

World Journal of Biological Chemistry 2010年第2期1卷 21-30页

作者： André Luis Souza dos Santos Laboratory of Multidisciplinary Studies on Microbial Biochemistry Department of General MicrobiologyInstitute of Microbiology Prof. Paulo de GóesFederal University of Rio de JaneiroRio de JaneiroRJ 21941-902Brazil

Cells of Candida albicans(***) can invade humans and may lead to mucosal and skin infections or to deep-seated my coses of almost all inner organs,especially in immunocompromised *** this context,both the host immune status and the ability of *** to modulate the expression of its virulence factors are relevant aspects that drive the candidal susceptibility or resistance;in this last case,culminating in the establishment of successful infection knownas *** possesses a potent arma-mentarium consisting of several virulence moleculesthat help the fungal cells to escape of the host *** is no doubt that the secretion of aspartyl-type proteases,designated as Saps,are one of the major virulence attributes produced by *** cells,since these hydrolytic enzymes participate in a wide range of fungal physiological processes as well as in different facets of the fungal-host *** these reasons,Saps clearly hold promise as new potential drug *** this hypothesis,the introduction of new anti-human immunodeficiency virus drugs of the as party l protease inhibitor-type(HIV PIs) have emerged as new agents for the inhibition of *** introduction of HIV PIs has revolutionized the treatment of HIV disease,reducing opportunistic infections,especially *** attenuation of candidal infections in HIV-infected individuals might not solely have resulted from improved immunological status,but also as a result of direct inhibition of *** *** this article,we review updates on the beneficial effects of HIV PIs against the human fungal pathogen ***,focusing on the effects of these compounds on Sap activity,growth behavior,morphological architecture,cellular differentiation,fungal adhesion to animal cells and abiotic materials,modulation of virulence factors,experimental candidiasis infection,and their synergistic actions with classical antifungal agents.

关键词： Candida albicans aspartyl protease Proteolytic inhibitors Human immunodeficiency virus Chemotherapy

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