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Noninvasive assessment of hepatic fibrosis in Egyptian patients with chronic hepatitis C virus infection

World Journal of Gastroenterology 2012年第23期18卷 2988-2994页

作者： Shawky Abdelhamid Fouad Serag Esmat Dalia Omran Laila Rashid Mohamed H Kobaisi Department of Internal Medicine Faculty of Medicine Cairo University Cairo 11562 Egypt Department of Tropical Medicine Faculty of Medicine Cairo University Cairo 11562 Egypt Department of Biochemistry Faculty of Medicine Cairo University Cairo 11562 Egypt Department of Pathology National Institute of Nephrology Cairo 35789 Egypt

AIM: To evaluate the accuracy of specific biochemical markers for the assessment of hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection. METHODS: One hundred and fifty-four patients with chronic HCV infection were included in this study; 124 patients were non-cirrhotic, and 30 were cirrhotic. The following measurements were obtained in all patients: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total bilirubin, prothrombin time and concentration, complete blood count, hepatitis B surface antigen (HBsAg), HCVAb, HCV-RNA by quantitative polymerase chain reaction, abdominal ultrasound and ultrasonic-guided liver biopsy. The following ratios, scores and indices were calculated and compared with the results of the histopathological examination: AST/ALT ratio (AAR), age platelet index (API), AST to platelet ratio index (APRI), cirrhosis discriminating score (CDS), Pohl score, G teborg University Cirrhosis index (GUCI). RESULTS: AAR, APRI, API and GUCI demonstrated good diagnostic accuracy of liver cirrhosis (80.5%, 79.2%, 76.6% and 80.5%, respectively); P values were: 0.05). In addition, we found significant correlations for the AAR, APRI, API, GUCI and Pohl score between the non-cirrhotic (F0, F1, F2, F3) and cirrhotic (F4) groups (P values: 0.05). CONCLUSION: The use of AAR, APRI, API, GUCI and Pohl score measurements may decrease the need

关键词： Age platelet index aspartate aminotrans-ferase platelet ratio index aspartate aminotransferase-to-alanine aminotransferase ratio Cirrhosis discrimi-nating score Fibrosis evaluation G^teborg UniversityCirrhosis index Hepatitis C virus infection Liver fibro-sis Pohl score

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