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asian variant intravascular large B-cell lymphoma with highly suspected central nervous system involvement:A case report

引用

World Journal of Clinical Cases 2023年第33期11卷 8058-8064页

作者： Yong-Pyo Lee Seung-Myoung Son Jihyun Kwon Department of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Pathology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea

BACKGROUND Intravascular large B-cell lymphoma(IVLBCL)is a rare subtype of extranodal *** particular,the asian variant of IVLBCL is characterized by hemophagocytic lymphohistiocytosis along with bone marrow ***,central nervous system(CNS)involvement is uncommon in this variant compared to the Western ***,we report a case of typical asian variant IVLBCL with highly suspected CNS involvement and discuss the nature of the disease and its genetic *** SUMMARY A 67-year-old female patient complained of gradually worsening cognitive *** hospitalized,she developed a high fever and showed marked *** imaging revealed a suspected leptomeningeal *** no malignant cells were found in the cerebrospinal fluid(CSF),the protein and lactate dehydrogenase levels in CSF were *** marrow examination revealed an increased number of hemophagocytic histiocytes,and 18F-fluorodeoxyglucose(FDG)positron emission tomography with computerized tomography scan revealed increased FDG uptake in both adrenal glands,the liver,and the right ethmoid sinus.A tissue biopsy showed atypical large lymphoid cells with prominent nucleoli in the vessels,and the tumor cells were positive for CD20,BCL2,BCL6,and IRF4/*** addition,targeted sequencing identified MYD88,TET2,and PIM1 ***,we diagnosed the patient with the asian variant of IVLBCL with highly suspected CNS *** Suspicion of IVLBCL and immediate diagnosis lead to timely ***,careful CNS examination at diagnosis is recommended.

关键词： Intravascular large B-cell lymphoma asian variant Hemophagocytic lymphohistiocytosis Central nervous system involvement Genetic alteration Case report

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