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Impact of high-fat diet on antioxidant status, vascular wall thickening and cardiac function in adult female LDLR<sup>–/–</sup>mice

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World Journal of Cardiovascular Diseases 2012年第3期2卷 184-192页

作者： Stéphanie Delemasure Carole Richard Ségolène Gambert Jean-Claude Guilland Catherine Vergely Patrick Dutartre Luc Rochette Jean-Louis Connat Biochemistry Department University Hospital Dijon France COHIRO Biotechnology Faculty of Medicine Dijon France Laboratory of Cardio-Metabolic Pathophysiology and Pharmacology Faculty of Medicine University of Burgundy Inserm UMR866 Dijon France

Background: Western diet, rich in saturated fatty acids and cholesterol, is associated with increased cardiovascular risk. We thus investigated in female mice the influence of this diet on plasma antioxidant status, vascular wall thickening and cardiac function. Methods and Results: Adult female C57BL/6J wild type (WT) and LDLR–/– mice were fed a normal diet (ND) or a high-fat diet (HFD) for 17 weeks. HFD induced an increase in plasma lipids and vitamin C (Vit C) levels in both groups but at a much higher level in LDLR–/– and a decrease in plasma ascorbyl free radical levels to Vit C ratio (an endogenous oxidative stress index) in LDLR–/–. We only found a slight decrease in circulating antioxidant status evaluated by the Oxygen Radical Absorbance Capacity (ORAC) assay in WT, but not in LDLR–/–. Echocardiography evidenced an increase in arterial wall thickness in aortic arch at atherosclerosis predilection sites in HFD LDLR–/– as compared to ND LDLR–/– and HFD WT. This result was confirmed by histology. Further-more, histological examination of aortic valves showed an increase in atherosclerotic lesions. Our study, using echocardiography, show that chronic HFD does not induce any major modifications of systolic function in the both mice groups. Conclusions: High-fat intake in mice causes serious disturbances in lipid plasma levels associated to variations of circulating antioxidant status due, at least in part, to an increase in Vit C. At this stage, atherosclerotic lesions, observed in aortic arch and valve, do not impair cardiac function in HFD-fed mice.

关键词： ascorbyl Free Radical Echocardiography Vitamin C High-Fat Diet Oxygen Radical Absorbance Capacity Oxidant/Antioxidant Status Systolic Function Aortic Arch

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