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Alteration of ascending colon mucosal microbiota in patients after cholecystectomy

World Journal of Gastrointestinal Surgery 2024年第8期16卷 2436-2450页

作者： Miao-Yan Fan Qiao-Li Jiang Meng-Yan Cui Meng-Qi Zhao Jing-Jing Wang Ying-Ying Lu Department of Gastroenterology Jiading Branch of Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201803China Shanghai Key Laboratory of Pancreatic Diseases Institute of Translational MedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China

BACKGROUND Cholecystectomy is a successful treatment option for gallstones,although the inci-dence of colorectal cancer(CRC)has notably increased in post-cholecystectomy(PC)***,it remains uncertain whether the altered mucosal micro-biota in the ascending colon is *** total,30 PC patients and 28 healthy controls underwent colonoscopies to collect mucosal biopsy *** patients were divided based on their clinical ***,16S-rRNA gene sequencing was used to analyze the amplicon,alpha diversity,beta diversity,and composition of the bacterial ***-tionally,the Phylogenetic Investigation of Communities by Reconstruction of Unobserved States(PICRUSt)database,sourced from the Kyoto Encyclopedia of Genes and Genomes,was used to predict the functional capabilities of the *** PC patients were comparable with healthy ***,PC patients older than 60 years had a distinct composition compared to those under 60 years *** richness was considerably higher at the phylum level in PC ***,Parabacteroides,and Bilophila were more abundant in the PC group than in the control ***,PC patients exhibited greater enrichment in metabolic pathways,specifically those related to lipopolysaccharide biosynthesis and vancomycin group antibiotic production,than *** This study indicated that the mucosal microbiota in PC patients was altered,perhaps offering new perspectives on the treatment possibilities for CRC and diarrhea following cholecystectomy.

关键词： Post-cholecystectomy ascending colon Mucosal Microbiota Colorectal cancer Diarrhea

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Image-guided conservative management of right colonic diverticulitis

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World Journal of Gastroenterology 2009年第46期15卷 5838-5842页

作者： Sun Jin Park Sung II Choi Suk Hwan Lee Kil Yeon Lee Department of Surgery Kyung Hee University School of Medicine

AIM： To study the clinical outcomes of medical therapy in patients with right colonic diverticulitis. METHODS： The records of 189 patients with right colonic diverticulitis which was finally diagnosed by computed tomography, ultrasonography, or operative findings were retrospectively reviewed. RESULTS： Of the 189 patients hospitalized for right colonic diverticulitis, the stages of diverticulitis by a modified Hinchey classification were 26 patients （13.8%） in stage 0, 139 patients （73.5%） in stage I a, 23 patients （12.2%） in stage I b, and 1 patient （0.5%） in stage Ⅲ. Medical therapy was undertaken in 185 of 189 patients （97.9%）. One hundred and eighty three of 185 patients were successfully treated with bowel rest and antibiotics. Two patients in stage I b required a resection or surgical drainage because of an inadequate response to conservative treatment. Recurrent diverticulitis developed in 15 of 183 patients （8.2%） who responded to medical therapy. All 15 patients who suffered a second attack had uncomplicated diverticulitis, and were successfully treated with medical ***： Our results indicate that right colonic diverticulitis is essentially benign and image-guided conservative treatment is primarily required.

关键词： ascending colon Cecum Medical therapy colonic diverticulitis

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Asymptomatic Anisakiasis of the colon Diagnosed and Treated by colonoscopy

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Case Reports in Clinical Medicine 2020年第9期9卷 288-294页

作者： Tomoshi Takeda Kenji Niwa Akie Sano Atsunori Kodama Kuninori Hatasa Yasunari Matsuno Masao Kagami Motoki Takenaka Kohjiro Niwa Takuji Tanaka Department of Internal Medicine Gujo City Hospital Shimadani Gujo City Gifu Japan Section of Laboratory Medicine and Obstetrics & Gynecology Gujo City Hospital Shimadani Gujo City Gifu Japan Sano Internal Medicine Clinic Naka-fukuno-cho Seki City Gifu Japan Department of Obstetrics & Gynecology Gifu University School of Medicine Yanagido Gifu City Japan Department of Internal Medicine Kizawa Memorial Hospital Shimokobi Kobicho Minokamo City Japan Department of Diagnostic Pathology & Research Center of Diagnostic Pathology Gifu Municipal Hospital Gifu City Japan

Anisakiasis can involve any part of the digestive tract, but most cases reported have involved the stomach;few reports have described colonic anisakiasis. Furthermore, asymptomatic colonic anisakiasis has been reported to be very rare. A 58-year-old Japanese male asymptomatically received colonoscopy due to a fecal occult blood testing positive, and an Anisakis larva was removed in the ascending colon. After colonoscopy, an detailed questionings concerning eating raw fish revealed that the patient ate the liver of raw filefish 21 days before the colonoscopy. Thus, questionings concerning eating the raw fish were very important and helpful for correct diagnosis. This case report demonstrated that colonic anisakiasis can be diagnosed by colonoscopy before severe complications (intestinal obstruction, perforation, and cancer development) occur. Also, biopsy forceps could be used to remove the Anisakis worms, demonstrating that diagnosis and treatment can be simultaneously performed.

关键词： Asymptomatic Anisakiasis ascending colon colonoscopy Risk Factor for Cancer

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