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Gastroprotective Effects of ascaridole on Gastric Ulcer in Rats

Chinese Herbal Medicines 2012年第1期4卷 58-62页

作者： Yong-hong ZHU[a][b] Xin-xin LI[b] Hong-mei MO[b] Li-hua ZHANG[b] Lan-lan ZHANG[b] Shui-ping ZHOU[b] Xiao-hui MA[b][c] Bo-li ZHANG[a] Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Department of Pharmacology and Toxicity Tasly R&D Institute Tianjin Tasly Group Co. Ltd. Tianjin 300410 China Department of Pharmacology and Toxicity Tasly R&D Institute Tianjin Tasly Group Co. Ltd. Tianjin 300410 China School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 China

Objective To evaluate the gastroprotective activity of ascaridole. Methods The gastroprotective effect of ascaridole was evaluated on ulcer healing in rats with acetic acid-induced chronic gastric ulcer, pylorus ligation- and Aspirin-induced gastric ulcer. ascaridole was ig administered with the dosages of 10 and 20 mg/kg once daily for 7 d. Results ascaridole showed the significant anti-ulcer effects. In acetic acid-induced gastric ulcer rats, the ulcer areas after 10 and 20 mg/kg of ascaridole treatment were (65.1 ± 20.0) and (50.6 ± 11.0) mm2, respectively, which were significant lower (P ascaridole showed a gastric ulcer healing effect in a dose-dependent manner. ascaridole at the dose of 20 mg/kg showed 50% ulcer protection and had a significant (P ascaridole showed the significant reduction (P ascaridole shows potential efficacy on the healing of gastric ulcers induced by acetic acid, Aspirin, and pylorus ligation.

关键词： ascaridole Aspirin chronic gastric ulcer gastroprotective effect pylorus ligation

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ascaridole: A phytochemical of modern medicinal perspective

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Journal of Coastal Life Medicine 2017年第2期5卷 88-94页

作者： Dinesh Kumar Patel Christian School of Pharmacy Faculty of Health SciencesSam Higginbottom Institute of AgricultureTechnology and Sciences(SHIATS)Deemed-to-be UniversityAllahabad211007Uttar PradeshIndia

American wormseed oil, also known as Chenopodium ambrosioides oil, is obtained from the herbs of the genus Chenopodium which comprises more than 200 species and belongs to the geographical region of Asia, Europe, China, India, America and other *** has been traditionally used for digestive, respiratory, diabetes, uro-genital, nervous and vascular disorders and has antihelminthic, vermifuge, emmenagogue sedative, antipyretic, antirheumatic and abortifacient activities. ascaridole is a bicyclic monoterpene commonly known as ascarisin or 1,4-epidioxy-p-menth-2-ene which have sedative, antifungal and pain-relieving properties. It is a potent inhibitor of Trypanosoma cruzi,Plasmodium falciparum, and Leishmania amazonensis and is well known for its worm-expelling potential. ascaridole was firstly isolated by a German pharmacist in the 1900's and at that time it was one of the best antihelmintics for the treatment of ascarids and hookworms in humans and other species like cats, dogs, horses and pigs. ascaridole could be extracted by using a non-polar solvent hexane due to its very poor solubility in water. From the literature support, it has been proved that ascaridole have very high potential in the modern and other system of medicine for the treatment of various disorders. So on the basic of its uses, here we have collected and compiled all the data regarding its medicinal uses, pharmacological activities and analytical techniques of the ascaridole in the present review and expected that this review will be beneficial for the researcher in the field of medicine and other allied science.

关键词： Analytical techniques Antihelminthic ascaridole Chenopodium ambrosioides Medicinal uses Pharmacological uses

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GC-MS法测定大鼠血浆中的ascaridole及其药动学研究

GC-MS法测定大鼠血浆中的ascaridole及其药动学研究

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2010年中国药学大会暨第十届中国药师周

作者：褚扬朱永宏李伟马晓慧周水平刘昌孝天津天士力集团研究院天津药物研究院

目的建立快速、灵敏的GC/MS法测定大鼠血浆中ascaridole的含量。方法 ascaridole与萘(内标)经乙酸乙酯萃取,采用HP-5MScapillary色谱柱(30m×0.25mm,0.25μm)进行分离,以质谱检测器采用选择离子监测方式进行定量分析。结果该方法的线性... 详细信息

目的建立快速、灵敏的GC/MS法测定大鼠血浆中ascaridole的含量。方法 ascaridole与萘(内标)经乙酸乙酯萃取,采用HP-5MScapillary色谱柱(30m×0.25mm,0.25μm)进行分离,以质谱检测器采用选择离子监测方式进行定量分析。结果该方法的线性范围为10000ng·mL-1,最低定量限为10ng·mL-1,准确度在85.3%14.0%之间,日内、日间精密度均小于14.5%。结论此法成功地用于研究ascaridole分别以30,60and120mg·kg-1单剂量灌胃给药后在大鼠体内的药代动力学,以及ascaridole以30mg·kg-1静脉注射给药后的药代动力学。ascaridole的绝对生物利用度约为14.0%。

关键词： ascaridole 土荆芥 GC/MS 药动学

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GC-MS法测定大鼠血浆中的ascaridole及其药动学研究

GC-MS法测定大鼠血浆中的ascaridole及其药动学研究

引用

2009年中国药学大会暨第九届中国药师周

作者：褚扬朱永宏李伟马晓慧周水平刘昌孝天津天士力集团研究院天津药物研究院

目的建立快速、灵敏的GC/MS法测定大鼠血浆中ascaridole的含量。方法ascaridole与萘(内标)经乙酸乙酯萃取,采用HP-5MScapillary色谱柱(30m×0.25mm,0.25μm)进行分离,以质谱检测器采用选择离子监测方式进行定量分析。结果该方法的线性... 详细信息

目的建立快速、灵敏的GC/MS法测定大鼠血浆中ascaridole的含量。方法ascaridole与萘(内标)经乙酸乙酯萃取,采用HP-5MScapillary色谱柱(30m×0.25mm,0.25μm)进行分离,以质谱检测器采用选择离子监测方式进行定量分析。结果该方法的线性范围为10000ng·mL-1,最低定量限为10ng·mL-1,准确度在85.3%14.0%之间,日内、日间精密度均小于14.5%。结论此法成功地用于研究ascaridole分别以30,60and120mg·kg-1单剂量灌胃给药后在大鼠体内的药代动力学,以及ascaridole以30mg·kg-1静脉注射给药后的药代动力学。ascaridole的绝对生物利用度约为14.0%。

关键词： ascaridole 土荆芥 GC/MS 药动学

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