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Designing artificial ion channels with strict K+/Na+ selectivity toward next-generation electric-eel-mimetic ionic power generation

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National Science Review 2023年第12期10卷 193-202页

作者： Jipeng Li Linhan Du Xian Kong Jianzhong Wu Diannan Lu Lei Jiang Wei Guo State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and Engineering Hainan University Department of Chemical Engineering Tsinghua University South China Advanced Institute for Soft Matter Science and Technology Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices School of Emergent Soft MatterSouth China University of Technology Department of Chemical and Environmental Engineering University of California Research Institute for Frontier Science Beihang University Center for Quantum Physics and Intelligent Sciences Department of Physics Capital Normal University

A biological potassium channel is> 1000 times more permeable to K+than to Na+and exhibits a giant permeation rate of ～108ions/*** is a great challenge to construct artificial potassium channels with such high sele ctivity and ion conduction ***,we unveil a long-overlo oked structural feature that underpins the ultra-high K+/Na+*** carrying out massive molecular dynamics simulation for ion transport through carbonyl-oxygen-modified bi-layer graphene nanopores,we find that the twisted carbonyl rings enable strict potassium selectivity with a dynamic K+/Na+selectivity ratio of 1295 and a K+conduction rate of 3.5 × 107ions/s,approaching those of the biological ***,atomic trajectories of K+permeation events suggest a dual-ion transport mode,*** like-charged potassium ions are successively captured by the nanopores in the graphene bi-layer and are interconnected by sharing one or two interlayer water *** dual-ion behavior allows rapid release of the exiting potassium ion via a soft knock-on mechanism,which has previously been found only in biological ion *** a proof-of-concept utilization of this discovery,we propose a novel way for ionic power generation by mixing KCl and NaCl solutions through the bi-layer graphene nanopores,termed potassium-permselectivity enabled osmotic power generation(PoPee-OP G).Theoretically,the biomimetic device achieves a very high power density of> 1000 W/m2with graphene sheets of artificial potassium channels and thus paves the way toward next-generation electric-eel-mimetic ionic power generation.

关键词： artificial ion channel bi-layer graphene dehydrated ion transport bio-inspired materials energy conversion

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Molecular rotaxane shuttle-relay accelerates K^(+)/Cl^(-) symport across a lipid membrane

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Science China Chemistry 2023年第8期66卷 2300-2308页

作者： Kai Ye Zekai Zhang Zexin Yan Shihao Pang Huiting Yang Xiaonan Sun Can Liu Linyong Zhu Cheng Lian Chunyan Bao Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistryInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai200237China State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismSchool of PharmacyEast China University of Science and TechnologyShanghai200237China

Synthetic molecules that can mediate the coupled transport of Cl^(-) with K^(+) and/or Na+across the lipid bilayers have aroused great interest due to their potential as a novel therapeutic strategy by disrupting cellular ion *** on the structural advantages of molecular rotaxanes,we herein show that two rotaxane-based transporters[2]R and[3]R induce coupled K^(+)/Cl^(-) channel transport by introducing Cl^(-) recognition sites in the thread and K^(+) binding group in the wheel,*** welldesigned molecular structures allow the insertion of unimolecular rotaxanes into the lipid bilayer,thus achieving effective ion transport by means of thermodynamically controlled movement and driven by the difference in ion concentration inside and outside the *** addition,the use of a three-component rotaxane can accelerate ion transport through a cooperative shuttlerelay mechanism in which two wheels move along the thread in the lipid membrane,thereby enabling[3]R to have higher ion transport *** work represents a major advance in the use of rotaxane molecules to accomplish more complex and effective tasks.

关键词： K^(+)/Cl^(-)symport molecular rotaxane artificial ion channel ion-pair recognition

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Self-assembled Supramolecular artificial Transmembrane ion channels:Recent Progress and Application

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Chemical Research in Chinese Universities 2023年第1期39卷 3-12页

作者： LUO Yichen ZHU Canhong ZHANG Tianlong YAN Tengfei LIU Junqiu College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationKey Laboratory of Organosilicon Material TechnologyHangzhou Normal UniversityHangzhou311121P.R.China

Natural protein channels have evolved with fantastic spatial structures,which play pivotal physiological functions in all living *** from nature,chemical scientists have developed a myriad of artificial transmembrane ion channels by using various chemical strategies,among which the non-covalent supramolecular ion channels exhibit remarkable advantages over other forms(e.g.,single-molecule ion channel),which exhibited facile preparation methods,easier structural modification and *** this review,we have systematically summarized the recent progress of supramolecular self-assembled artificial transmembrane ion channels,which were classified by different self-assembly mechanisms,such as hydrogen bonds,π-πinteractions,*** preparation process and self-assembly strategies of the supramolecular ion channels have been ***,potential biomedical applications of the supramolecular ion channels have also been carefully discussed in this ***,future opportunities and challenges facing this field were also elaborately *** is anticipated that this review could provide a panoramic sketch and future directions towards the construction of novel artificial ion channels with novel functions and biomedical applications.

关键词： Self-assembly Supramolecular artificial ion channel Biomedical application

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