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An artificial heart System for Testing and Evaluation of Cardiac Pacemakers

Computers, Materials & Continua 2022年第12期73卷 6269-6287页

作者： Martin Augustynek Jan Kubicek Jaroslav Thomas Marek Penhaker Dominik Vilimek Michal Strycek Ondrej Sojka Antonino Proto Department of Cybernetics and Biomedical Engineering Faculty of Electrical Engineering and Computer ScienceVSB-Technical University of Ostrava17.Listopadu 15Ostrava–Poruba70800Czech Republic

The usability assessment of a pacemaker is a complex task where the dedicated programmer for testing programmed algorithms is *** paper provides the outcomes of development and complex testing of the artificial cardiac system to evaluate the pacemaker’s *** this work,we used the modular laboratory platform ELVIS II and created graphical user interface in LabVIEW programming *** electrical model of the heart allows signals generation(right atrium,right ventricle)and the monitoring of the stimulation *** LabVIEW user interface allows to set the parameters of the generated signals and the simulation of the cardiac rhythm disorders as well as the monitoring and visualization of the pacemaker behavior in *** results demonstrate the capability of proposed system to evaluate the paced and sensed *** proposed solution allows the scientists to test the behavior of any cardiac pacemaker for its pre-programmed settings and pacing *** addition,the proposed system can simulate various disorders and test cardiac pacemakers in different working modes.

关键词： artificial heart cardiac conduction system electrical cardiac stimulation pacemaker

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On the understanding of dielectric elastomer and its application for all-soft artificial heart

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Science Bulletin 2021年第10期66卷 981-990,M0003页

作者： Wenjie Wu Shuangkun Zhang Zhanpeng Wu Sichen Qin Fanzhu Li Tianfu Song Xia Cao Zhong Lin Wang Liqun Zhang Center of Advanced Elastomer Materials State Key Laboratory of Organic-Inorganic CompositesBeijing University of Chemical TechnologyBeijing 100029China Engineering Research Center of Ministry of Education on Energy and Resource Saved Elastomers Beijing University of Chemical TechnologyBeijing 100029China Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100140China Research Center for Bioengineering and Sensing Technology Beijing Key Laboratory for Bioengineering and Sensing TechnologySchool of Chemistry and Biological Engineeringand Beijing Municipal Key Laboratory of New Energy Materials and TechnologiesUniversity of Science and Technology BeijingBeijing 100083China Key Laboratory of Carbon Fiber and Functional Polymers Beijing University of Chemical Technology(Ministry of Education)Beijing 100029China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332-0245USA State Key Laboratory of Alternate Electric Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China

Although dielectric elastomer(DE)with substantial actuated strain(AS)has been reported 20 years ago,its scientific understanding remains *** most accepted theory of DE,which is proposed in 2000,holds the view that AS of DE is induced by the Maxwell *** to this theory,materials have similar ratios of permittivity and Young’s modulus should have similar AS,while the experimental results are on contrary to this theory,and the experimental AS has no relationship with ideal ***,a new dipole-conformation-actuated strain cross-scale model is proposed,which can be generally applied to explain the AS of DE without *** to this model,several characteristics of an ideal DE are listed in this work and a new DE based on polyphosphazene(PPZ)is *** AS of PPZ can reach 84%without any *** last,a PPZ-based all soft artificial heart(ASAH)is built,which works in the similar way with natural myocardium,indicating that this material has great application potential and possibility in the construction of an ASAH for heart failure(HF)patients.

关键词： Polyphosphazene Dielectric elastomer artificial heart heart failure

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Systematical Experiment for Optimal Design of Vibrating Flow Pump with Jelly-fish Valve

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Journal of Bionic Engineering 2016年第1期13卷 166-179页

作者： Satoyuki Kawano Saki Miyagawa Atsushi Shirai Graduate School of Engineering Science Osaka University Osaka 560-8531 Japan Institute of Fluid Science Tohoku University Sendai 980-8577 Japan

The fundamental characteristics and the flow mechanism of a Vibrating Flow Pump （VFP） with a jelly-fish valve, which can be applied to a novel artificial heart, were studied theoretically and experimentally. By using water as the working fluid, the measurement methodology for the typical unsteady flow for VFP was developed here. The effects of the frequency, amplitude and inner diameter of the vibrating pipe, and thickness of the silicone rubber sheet of the jelly-fish valve on the basic per- formance of VFP were systematically investigated. A high-speed observation technique and simple theoretical model analysis were also introdueed for further detailed discussion. Quantitative contributions of the individual parameters to the pumping performance were shown through the experiment, which would give us essential knowledge for establishing design criteria of VFE The theoretical model, which agreed with the experiment and the high-speed observation, elucidated the pumping mechanism with respect to the role of inertia of the inner fluid.

关键词： vibrating flow pump artificial heart left ventricular assistance jelly-fish valve pump performance H-Q curve

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Preface for the special issue on regenerative medical materials

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Frontiers of Materials Science 2014年第1期8卷 1-2页

作者： Shengmin Zhang (1) Rizhi Wang (2) 1. Huazhong University of Science and Technology Huazhong China2. The University of British Columbia Vancouver Canada

Biomaterials science is undoubtedly at the frontier of materials science and engineering. It bridges materials science with biology and medicine, and more importantly its progress brings direct impact to improving health and quality of life for many of us. Traditionally, biomedical implants are made from common engineering materials to replace human tissues or organs. A good example is the artificial joints made of cobalt-chromium alloy, titanium alloy, and high density polyethylene. Over 1 million total hip arthroplasties are performed annually in North America. They effectively relieve pain and restore mobility of those suffering from osteoarthritis and osteoporosis. Other well-known biomedical implants developed in the 20th century are dental implants, artificial heart valves, coronary stents, and artificial hearts. Although effective in achieving the functions, these biomaterials share the same drawback： they are inert and do not actively interact with the surrounding tissues. The injured tissues or organs are replaced permanently by non-viable materials without the possibility of regeneration.

关键词： artificial heart Materials Science and Engineering Total Joint Replacement Biocompatible Materials Inert Distress Medicine materials science medical materials human tissue Regenerative Organ High Density Polyethylene Engineering Materials Osteoarthritis

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人工心脏临床应用研究(英文)

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中国医学工程 2002年第6期10卷 42-44页

作者：陈国涵刘中民卢蓉郭建华范慧敏刘泳李高平施巍巍李健上海市东方医院同济大学附属东方医院上海200120

Objective:To summarize practical experiences of clinical application of artificial heart and discuss its indications and prevention of complications. Methods: Before operation, all the four patients underwent regular treatment of internal medicine, and after its failure they were implanted with artificial hearts. Operations were performed under general anesthesia and external circulation at low temperature. Left ventricle assistant devices (LVAD) were used for three patients, and double ventricle assistant device (DVAP) for one. Two patients were embeded with Berlin artificial hearts (Melipot company). The other two were implanted with Medos artificial hearts ( Medos company). Results:All the patients had no infection and haemorrhage, while their cardiac functions were restored apparently. Three to five days after operation, patients could take off- bed activities. Two had been taken away their artificial hearts on 52th and 53th postoperative day, and arrhythmia disappeared. Half year follow- up revealed favorable results. One died,on 271st day,of bleeding from congenital cerebrovascular deformity. One died, on 10th postoperative day, of renal dysfunction and DIC. Conclusion: artificial heart or Ventricle assistant devices (VAD) could be used as temporary substitute for heart transplantation, and used in emergent heart attacks in order to restore cardiac function.

关键词： artificial heart Clinical Application heart Failure

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