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Anti-arthritis activity of roots of Hemidesmus indicus ***.(Anantmul)in rats

Asian Pacific Journal of Tropical Medicine 2012年第2期5卷 130-135页

作者： Alka Mehta Neeraj K Sethiya Chetan Mehta GB Shah Pharmacy Department Faculty of Technology and Engineering KalabhavanThe M.S.University of BarodaVadodara 390002(Gujarat)India Radiology Department SSG Hospital and Medical CollegeVadodara-390001(Gujarat)India KBIPER Gandhinagar-382023(Gujarat).India

Objective:To investigate the protective effects of hydroalcoholic and its fractions from roots of Hemidesmus indicus on arthritis in in vitro models of ***:Preliminary phytochemical analysis and thin-layer chromoatography were performed to analyze constituents of hydroalcoholic extract and its three fraction namely ethyl acetate fraction,chloroform fraction and residual fraction of mot of Hemidesmus *** rats models were established by Complete Freund’s *** parameters including paw edema,body weight,arthritic index,erythrocyte sedimentation rate,serum rheumatoid factor,serum C-reactive protein,serum nitrite level,and histopathology of synovial joints were *** was taken as positive ***:Rats treated with hydroalcoholic extract(450 mg/kg,p.o.),ethyl acetate (75 mg/kg,p.o.),chloroform(60 mg/kg,p.o) and residual fractions(270 mg/kg,p.o.),showed significant decrease in physical and biochemical parameters compared with arthritic model rats. Hydroalcoholic extract and its ethyl acetate fraction of Hemidesmus indicus showed significantly higher anti-arthritic activity than chloroform and residual *** analysis demonstrated that both of hydroalcoholic extract and its ethyl acetate fraction had comparable anti-arthritic activity with ***:The present study suggests that Hemidesmus indicus has protective activity against arthritis and the activity might be attributed to presence of terpenoid in hydroalcoholic extract,as well as in ethyl acetate fraction.

关键词： arthritic Index Hemidesmus indicus Anti-inflammatory Phenolic Terpenoids

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Multisystem Inflammatory Disease with Respiratory Failure in a 7-Year-Old Boy

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Case Reports in Clinical Medicine 2018年第12期7卷 594-600页

作者： Gurpreet Phull Prateek J. Shukla Dinesh K. Pillai Division of Pulmonary and Sleep Medicine MedStar Georgetown University Hospital Washington DC USA Division of Pulmonary and Sleep Medicine Children’s National Health System Washington DC USA

Relapsing polychondritis (RP) is a rare episodic and progressive inflammatory disease of presumed autoimmune etiology. The estimated incidence is 3.5 cases per million. Of these only 10% affect pediatric populations.

关键词： Polychondritis Chronic Atrophic Meyenburg-Altherr-Uehlinger Syndrome Atrophic Polychondritis Cartilaginous arthritic Deafness Syndrome

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