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Hepatoprotective and antioxidant activity of ethanolic extract of artabotrys odoratissimus stem on rifampicin-induced hepatotoxicity in rats

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Drug Combination Therapy 2021年第2期3卷 9-17页

作者： Hindustan Abdul Ahad Chinthaginjala Haranath Bhupalam Pradeepkumar Beludari Mohammed Ishaq Department of Industrial Pharmacy Raghavendra Institute of Pharmaceutical Education and Research(RIPER)-AutonomousKR Palli CrossCheyyedu-515721AnanthapuramuAndhra PradeshIndia Department of Pharmacology Raghavendra Institute of Pharmaceutical Education&Research(RIPER)-AutonomousKR Palli CrossCheyyedu-515721Andhra PradeshIndia Department of Pharmaceutical Analysis Santhiram College of PharmacyNandyal-518501Kurnool Dist.Andhra PradeshIndia

The area of the existing examination was to explore the cancer prevention agent and hepatoprotective action of ethanolic stem concentrate of artabotrys odoratissimus in rifampicin caused hepatotoxicity in albino wister *** material was dehydrated in gloom;they were powdered,extricated with ethanol later primer phytochemical tests were *** hepatoprotective action of the ethanol extract was evaluated in albino wister ***(100 mg/kg)has upgraded the degrees of different biochemical markers of the liver like serum glutamic oxaloacetic transaminase,serum glutamate pyruvate transaminase,aspartate alkaline phosphatase and *** different biochemical and histopathological examinations have done were aspartate alkaline phosphatase,aminotransferase,alanine transaminase,bilirubin,cell reinforcement movement by 1,1-diphenyl 2-picryl hydrazyl,nitro blue tetrazolium,hydrogen peroxide,lipid perioxidation,hydroxyl revolutionary and nitric oxide *** of ethanolic concentrate of the stem of artabotrys odoratissimus(100 mg/kg,200 mg/kg and 400 mg/kg)has brought back the changed degrees of biochemical markers to the close ordinary levels in the portion subordinate *** discoveries proposed that artabotrys odoratissimus ethanol stem extricate had an intense cell reinforcement and hepatoprotective action.

关键词： artabotrys odoratissimus Rifampicin Liver protection Histopathology

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