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Safety,effectiveness,and cost-effectiveness of argusⅱin patients with retinitis pigmentosa:a systematic review

International Journal of Ophthalmology(English edition) 2021年第2期14卷 310-316页

作者： Zakieh Ostad-Ahmadi Amin Daemi Mohammad-Reza Modabberi Ali Mostafaie Department of Health Management Policy and EconomicsSchool of Management and Medical InformaticsKerman University of Medical SciencesKerman ***Iran Health Management and Economics Research Center Iran University of Medical SciencesTehran ***Iran Student Research Committee School of Public HealthShahid Beheshti University of Medical SciencesTehran 198353Iran Iranian Center for Evidence Based Medicine Tabriz University of Medical SciencesTabriz ***Iran

AIM:To assess the effectiveness,safety,and costeffectiveness of the argus II in treatment of the retinitis pigmentosa(RP)***:The Pro Quest,Web of Science,EMBASE,MEDLINE(via Pub Med)were searched using combinations of the keywords of argus,safety,effectiveness,bionic eye,retinal prosthesis,and RP through March *** retrieved records were screened and then assessed for ***:Totally 926 records were retrieved from the searched databases and finally 12 studies *** RP patients showed improvements in visual function after receiving the prosthesis,compared to the time before the prosthesis or the time it was *** was measured by square localization,direction of motion,and grating visual acuity *** major adverse effect was reported for the argus II prosthesis itself and/or the surgery to implement it,but the most frequently reported items were hypotony,and conjunctival *** incremental cost-effectiveness ratio(ICER)was calculated to be€14603 per qualityadjusted life year(QALY)in UK and$207616 per QALY in ***:The available evidence shows that the argus II prosthesis in RP patients is effective in improvement of their visual *** minor adverse effects are reported for the *** cost-effectiveness studies show that the technology is cost-effective only at high levels of willingness-to-pay.

关键词： retinitis pigmentosa argusⅱ retinal prosthesis effectiveness adverse cost-effectiveness

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