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argemone mexicana extract alleviates gastrointestinal disorders by stimulating muscarinic receptors and blocking voltage-gated L-type calcium channels

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Asian Pacific Journal of Tropical Biomedicine 2021年第5期11卷 214-221页

作者： Rabia Iqbal Irfan Hamid Khalid Hussain Janbaz Muhammad Furqan Akhtar Ammara Saleem Ali Sharif Sohaib Peerzada Bushra Akhtar Kashif Sohail Sajid Ali Faculty of Pharmacy The University of LahoreLahorePakistan Cadson College of Pharmacy University of the PunjabLahorePakistan Department of Pharmacology Bahauddin Zakariya UniversityMultanPakistan Riphah Institute of Pharmaceutical Sciences Riphah International UniversityLahore CampusLahorePakistan Department of Pharmacology Faculty of Pharmaceutical SciencesGovernment College University FaisalabadFaisalabadPakistan Department of Pharmacology Faculty of Pharmaceutical and Allied health SciencesLahore College for Women UniversityLahorePakistan Institute of Pharmacy Physiology and PharmacologyUniversity of AgricultureFaisalabadPakistan Akson College of Pharmacy Mirpur University of Science and TechnologyMirpurAJKPakistan

Objective:To investigate the pharmacological potential of argemone mexicana in treating constipation and emesis by using in vitro and in vivo ***:The spasmogenic and spasmolytic effects were evaluated on isolated rabbit jejunum fragments loaded in a tissue organ *** response was recorded with an isotonic transducer attached with Power Lab Data Acquisition *** laxative and antiemetic activities were assessed in BALB-c mice and poultry chicks challenged with carbamylcholine and copper sulphate stimulated emesis,***:The total phenolic and total flavonoids contents of the extract were(267.75±5.77)mg GAE/g and(73.86±6.01)mg QE/g,*** mexicana extract exerted spasmogenic effect on isolated rabbit jejunum segments with an EC_(50)value of 0.016 mg/m L,which was blocked by atropine(0.3μM).argemone mexicana extract exerted spasmolytic effect in atropine treated jejunum fragments with an EC_(50)value of 2.185 mg/***,argemone mexicana extract relaxed potassium(80 mM)-induced contractions(EC_(50):9.07 mg/mL),similar to a standard drug *** calcium channel blocker activity was confirmed by a rightward shift of concentration-response curve of calcium in the presence of argemone mexicana extract(1-5 mg/mL)and verapamil(0.1-1μM).In addition,the extract increased the distance travelled by a charcoal in the gastrointestinal tract and exhibited antiemetic effect on copper sulphate induced emesis in ***:argemone mexicana shows cholinergic agonist and calcium channel blocker activities,as well as antiemetic *** may be used as a potential agent for treating gastrointestinal disorders.

关键词： argemone mexicana Muscarinic agonist Calcium channel blocker Constipation Emesis

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