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The Protective Effect of arabinose + Mannose on Mice with Acute Liver Injury Induced by CCl_4 and Its Mechanism

Medicinal Plant 2017年第1期8卷 48-50页

作者： Simao HUANG Ya GAO Houkang CAO Kefeng ZHANG Guilin Medical University

[Objectives] Taking mice with acute liver injury induced by CCl_4 as the model,the effect of arabinose + mannose( w/w = 1∶ 1) on mice with acute liver injury induced by CCl_4 was studied. [Methods]60 experimental mice were selected and then randomly divided into normal control,model group and positive group( bifendate 120 mg/kg),high-dose arabinose + mannose group( 800 mg/kg),middle-dose arabinose + mannose group( 400 mg/kg) and low-dose arabinose + mannose group( 200 mg/kg),each group had 10 mice,which were fed adaptively for 1 week. Except normal control group and model group,each treatment group was given medicine by gavage once a day and lasted for7 days according to the dosage of 20 ml/kg. After the last drug,except normal control group,the mice of other groups were injected 10 ml/kg0. 12% CC14 peanut oil through enterocoelia,thereby establishing acute liver injury model. The mice were fasted but not water for 24 h,after that,blood was sampled from mice eyes,then dissected rapidly. The activities of ALT and AST in the serum were determined,the expression levels of TNF-α,IL-1β and IL-6 from the hepatic tissues were detected by enzyme-linked immunosorbent assay( ELISA); then after HE dye,the changes of liver histopathology were observed. [Results]Compared with CCl_4 model,the activities of ALT and AST from the serum of mice from high-dose and middle dose groups decreased significantly( P arabinose + mannose has an obvious protective effect on mice with acute liver injury induced by CCl_4,and its mechanism may relate to anti-inflammatory.

关键词： arabinose Mannose CCl4 Acute liver injury Anti-inflammatory

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Carbon quantum dots modified TiO_(2) composites for hydrogen production and selective glucose photoreforming

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Journal of Energy Chemistry 2022年第1期31卷 201-208,I0006页

作者： Heng Zhao Xinti Yu Chao-Fan Li Wenbei Yu Aiguo Wang Zhi-Yi Hu Steve Larter Yu Li Md Golam Kibria Jinguang Hu Department of Chemical and Petroleum Engineering University of Calgary2500 University DriveNWCalgaryAlberta T2N 1N4Canada State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070HubeiChina Nanostructure Research Centre Wuhan University of Technology.Wuhan 430070Hubei.China Department of Geosciences University of Calgary2500 University DriveNWCalgaryAlberta T2N 1N4Canada

Lignocellulosic biomass photoreforming is a promising and alternative strategy for both sustainable H_(2) production and biomass valorization with infinite solar ***,harsh reaction conditions(high alkalinity or toxic organic solvents),with low biomass conversion and selectivity are often reported in *** this work,we report glucose photoreforming for coproduction of H_(2) and arabinose with improved selectivity under neutral condition using carbon quantum dots(CQDs)modified TiO_(2) *** show that the conventional CQDs fabricated by a facile one-step hydrothermal process could be endowed with novel color changing property,due to the particle aggregation under the regulation of incident *** as-fabricated CQDs/TiO_(2) composites with certain colored CQDs could greatly improve glucose to arabinose conversion selectivity(-75%)together with efficient hydrogen evolution(up to 2.43 mmolh^(-1)g^(-1))in *** arabinose is produced via the direct C1-C2 α-scissions mechanism with reactive oxygen species of·O_(2)^(-) and·OH,as evidenced by ^(13)C labeled glucose and the electron spin-resonance(ESR)studies,*** work not only sheds new lights on CQDs assisted photobiorefinery for biomass valorization and H_(2) coproduction,but also opens the door for rationale design of different colored CQDs and their potential applications for solar energy utilization in the noble-metal-free system.

关键词： CQDs Size regulation Hydrogen production Glucose photoreforming arabinose

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