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第六届泛环渤海生物化学与分子生物学会学术交流会

作者： Dan Cui Linlin Sui Yanni Ma Chenyang Zhu Zhenzhen Guo Man Zhang Ying Kong Department of Biochemistry and Molecular Biology Dalian Medical University

Embryo implantation is an extremely complex process and the endometrium receptivity is vital forsuccessful embryo *** and progestogen are known to regulate the endometrium receptivity to induce both temporal and spatial synchronization of the uterine endometrium and the *** study is aimed to investigate the mechanism of AQP3 regulated by E2P4(17 β-estradiol and progesterone) which affect the endometrial *** we show that expression of AQP3 inthe mid-secretory and late-secretory phase of human endometrium is significantly higher than other phases.E2P4 up-regulates AQP3 expression more significantly compared to the single function of E2 and ***,for the first time,report that P4 up-regulates AQP3 by directly targeting the promoter of the AQP3 gene.E2P4 promote RL95-2 cells migration and invasion,by inducing the epithelial-mesenchymal transition(EMT) through *** other innovation is thatwe find AQP3 co-localized with ezrin,and affect the formation of filopodia and lamellipodia duringEMT process by E2P4,but has no effect on the expression of ezrin and *** data indicate that AQP3 might be regulated by E2P4 to influence endometrial migration and invasion to establish endometrial receptivity.

关键词： aquaporin-3 E2P4 uterine endometrium embryo promote

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Effect of Cyclosporin a Eye Drop on Keratoconjunctivitis Sicca and Its Mechanism

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2005年第6期25卷 738-740页

作者：孙京华刘常明张煜昭王慧 Department of Ophthalmology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

In this study, the effect of cyclosporin A （CsA） eye drop on keratoconjunctivitis Sicca （KCS） and its mechanism were studied. The KCS models were established by injecting Pertussis vaccine, complete freund＇s adjuvant （CFA） and antigen of conjunctiva from isotype mice. Then the KCS models were treated with cyclosporin A eye drop. Changes in breaking-up time （BUT）, lacrimal secretion in 30 min and diversion in 24 h were measured. The percentage of beaker cells, the lymphocytic infiltration in conjunctiva were observed. The expression levels of aquaporin-3 （AQP3） in conjunctiva epithelial cells, beaker cells and accessory lacrimal gland were immunohistochemically detected. The results showed that there were significant differences in BUT, the percentage of beaker cells, lacrimal secretion in 30 min, the lymphocytic infiltration and the expression of AQP3 between the experimental group and an control group. It was *** CsA eye drop exerts marked therapeutic effect on KCS by inhibiting T lymph cells, increasing the goblet cells and AQP3 expression in conjunctiva.

关键词： keratoconjunctivitis sicca cyclosporin A eye drop beaker cell aquaporin-3

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Identification of the multiple bioactive derivatives and their endogenous molecular targets that may mediate the laxative effect of rhubarb in rats

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Journal of Traditional Chinese Medical Sciences 2020年第2期7卷 210-220页

作者： Lei Xie Ying Wang Gan Luo Wenjuan Zhou Jiayan Miao Siqi Tang Qin Jiang Yage Guan Xiaoyan Gao School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China

Objective:To determine the mechanism of the laxative effect of rhubarb(Rheum tanguticum *** Balf.)in rats using a combined bioinformatic and in vivo ***:Substances derived from rhubarb that are present in the colorectum were identified using high-performance liquid chromatography,coupled with linear ion-trap quadrupole Orbitrap highresolution mass *** targets with a potential laxative effect were identified from databases and the literature,then used with rhubarb-derived substances in molecular docking *** expression of candidate endogenous target molecules that bound specific components of rhubarb was then measured in constipated rats that had or had not been administered rhubarb by western ***,potentially bioactive compounds were traced back to their prototype ***:We identified 17 anthraquinones and 21 anthrones derived from rhubarb in the colorectum of rats.G-scoring identified three potential mediators of the laxative effect:c-kit,5-hydroxytryptamine receptor 4(5-HT4),and aquaporin-3(AQP3).In addition,10 rhubarb-derived components(aloeemodin,emodin,rhein,chrysophanol,physcion,sennoside A,sennoside C,physcionanthrone,aloeemodinanthrone,and rheinanthrone),which have strong binding affinities for more than one of the three potential targets,were selected as likely active *** extract increased the expression of c-kit and 5-HT4,and reduced the expression of AQP3 in the colon of constipated rats,which might mediate its laxative *** also found that a single prototype component may be metabolized into several active metabolites,and a single active ingredient can also be generated from various prototype ***:The present study demonstrates that various anthraquinones and anthrones present in rhubarb may be metabolized to form bioactive compounds that have additive or synergistic effects to promote defecation via c-kit,5-HT4 and/or AQP3.

关键词： Rhubarb Laxative Anthraquinones Anthrones C-kit aquaporin-3

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