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Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution

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Bioactive Materials 2022年第3期7卷 183-197页

作者： Lili Bao Geng Dou Ran Tian Yajie Lv Feng Ding Siying Liu Ruifeng Zhao Lu Zhao Jun Zhou Lin Weng Yan Dong Bei Li Shiyu Liu Xin Chen Yan Jin State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral Diseases Center for Tissue EngineeringSchool of StomatologyThe Fourth Military Medical UniversityXi’an710032China School of Chemical Engineering and Technology Shaanxi Key Laboratory of Energy Chemical Process IntensificationInstitute of Polymer Science in Chemical EngineeringXi’an Jiao Tong UniversityXi’an710049China Department of Dermatology Tangdu HospitalThe Fourth Military Medical UniversityXi’an710038China State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi International Joint Research Center for Oral Diseases Center for Digital DentistrySchool of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi710032China State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral Diseases Department of Oral and Maxillofacial SurgerySchool of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi710032China

Inflammatory response plays a critical role in myocardial infarction(MI)*** neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation resolution and initiate regeneration,while the therapeutic strategy that simulates and enhances this natural process has not been ***,we constructed engineered neutrophil apoptotic bodies(eNABs)to simulate natural neutrophil apoptosis,which regulated inflammation response and enhanced MI *** eNABs were fabricated by combining natural neutrophil apoptotic body membrane which has excellent inflammation-tropism and immunoregulatory properties,and mesoporous silica nanoparticles loaded with hexyl 5-aminolevulinate hydrochloride(HAL).The eNABs actively targeted to macrophages and the encapsulated HAL simultaneously initiated the biosynthesis pathway of heme to produce anti-inflammatory bilirubin after intracellular release,thereby further enhancing the anti-inflammation *** in vivo studies,the eNABs efficiently modulated inflammation responses in the infarcted region to ameliorate cardiac *** study demonstrates an effective biomimetic construction strategy to regulate macrophage functions for MI repair.

关键词： Neutrophils apoptotic bodies Engineering Inflammation Myocardial infarction

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In situ delivery of apoptotic bodies derived from mesenchymal stem cells via a hyaluronic acid hydrogel:A therapy for intrauterine adhesions

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Bioactive Materials 2022年第6期7卷 107-119页

作者： Liaobing Xin Cheng Wei Xiaomei Tong Yangyang Dai Dong Huang Jianmin Chen Lie Ma Songying Zhang Assisted Reproduction Unit Department of Obstetrics and GynecologySir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou310016China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province.No.3 Qingchun East Road Jianggan DistrictHangzhou310016China

Stem cell-based and stem cell-derived exosome-based therapies have shown promising potential for endometrial regeneration and the clinical treatment of intrauterine adhesions(IUAs).Evidence shows that apoptosis occurs in a majority of grafted stem cells,and apoptotic bodies(ABs)play a critical role in compensatory tissue ***,the therapeutic potential of AB-based therapy and its mechanism have not been explored in ***,a cell-free therapeutic strategy was developed by incorporating mesenchymal stem cell-derived ABs into a hyaluronic acid(HA)hydrogel to achieve endometrial regeneration and fertility ***,we found that the ABs could induce macrophage immunomodulation,cell proliferation,and angiogenesis in *** HA hydrogel promoted the retention of ABs and facilitated their continuous *** a murine model of acute endometrial damage and a rat model of IUAs,in situ injection of the AB-laden HA hydrogel could efficiently reduce fibrosis and promote endometrial regeneration,resulting in the fertility ***,ABs show good potential as therapeutic vesicles,and the AB-laden HA hydrogel appears to be a clinically feasible and cell-free alternative for endometrial regeneration and IUA treatment.

关键词： apoptotic bodies Mesenchymal stem cells Endometrial regeneration Intrauterine adhesions Tissue engineering

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