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Combined Surgical Treatment of Atherosclerotic Coronary Artery Disease and Moderate aortic valve Stenosis in Patient with Concomitant Lipton’s R-III Type of Single Coronary Artery Anomaly

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Congenital Heart Disease 2021年第6期16卷 647-653页

作者： Milica Karadzic Kocica Hristina Ugrinovic Dejan Lazovic Nemanja Karamarkovic Milos Grujic Borivoje Lukic Oliver Radmili Vladimir Cvetic Mladen Kocica Centre for Anesthesiology and Reanimatology UC Clinical Centre of SerbiaBelgrade11000Serbia Clinic for Cardiac surgery UC Clinical Centre of SerbiaBelgrade11000Serbia Clinic for Vascular and Endovascular surgery UC Clinical Centre of SerbiaBelgrade11000Serbia

A single coronary artery is a very rare condition,commonly associated with other congenital *** could be generally considered as neither benign nor malignant form of congenital coronary artery anomalies since its pathophysiological and clinical implications grossly depend on different anatomical patterns defined by the site of origin and distribution of the *** presenting the patient who underwent successful coronary artery bypass grafting and aortic valve replacement surgery in a presence of isolated single coronary artery,we intend to emphasize natural and procedural risks and distinguish casual from causal in this extremely rare clinical and surgical scenario.

关键词： Single coronary artery aortic stenosis angina pectoris aortic valve surgery coronary artery bypass grafting surgery

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Is there evidence for statins in the treatment of aortic valve stenosis?

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World Journal of Cardiology 2017年第8期9卷 667-672页

作者： Ibrahim Akin Christoph A Nienaber Medical Faculty Mannheim University Heidel- berg Royal Brompton Hospital and Harefield Trust

Research revealed that the pathogenesis of aortic stenosis(AS) not merely comprises of a mechanical wear and tear process yet that active biological processes, similar to those of coronary artery disease are involved, a promising role for statins in disease-modifying therapy was suggested. However, recently, many prospective studies could not observe decreased progression nor regression of the disease. Here, we review the current knowledge on the pathomechanisms of AS and its similarities and differences with atherosclerosis. Moreover, we discuss whether there is still a place for statins in the treatment of particular AS patient subgroups.

关键词： aortic stenosis Statins HMG-CoA enzyme inhibitor Coronary artery stenosis aortic valve surgery

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