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Association of alcohol consumption with aortic aneurysm and dissection risk:results from the UK Biobank cohort study

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World Journal of Emergency Medicine 2024年第6期15卷 465-474页

作者： Yaowen Liang Guoxiang Zou Dingchen Wang Weiyue Zeng Jiarui Zhang Xiaoran Huang Miao Lin Cong Mai Fei'er Song Yuelin Zhang Jinxiu Meng Hongliang Feng Yu Huang Xin Li Department of Emergency Medicine Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Shantou University Medical College Shantou 515063China South China University of Technology Guangzhou 510080China Medical Big Data Center Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Critical Care Medicine Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Center for Sleep and Circadian Medicine the Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510080China Department of Ophthalmology Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China

BACKGROUND:Previous studies have reported inconsistent results with positive,negative,and J-shaped associations between alcohol consumption and the hazard of aortic aneurysm and dissection(AAD).This study aimed to examine the connections between weekly alcohol consumption and the subsequent risk of ***:The UK Biobank study is a population-based cohort *** alcohol consumption was assessed using self-reported questionnaires and the congenital risk of alcohol consumption was also evaluated using genetic risk score(GRS).Cox proportional hazards models were used to estimate hazard ratios(HRs)with 95% confidence intervals(CIs)for the associations between alcohol consumption and *** sensitivity analyses were performed to assess the robustness of the ***:Among the 388,955 participants(mean age:57.1 years,47.4% male),2,895 incident AAD cases were documented during a median follow-up of 12.5 *** with never-drinkers,moderate drinkers(adjusted HR:0.797,95%CI:0.646-0.984,P<0.05)and moderate-heavy drinkers(adjusted HR:0.794,95%CI:0.635-0.992,P<0.05)were significantly associated with a decreased risk of incident ***-based subgroup analysis revealed that the protective effect of moderate drinking was reflected mainly in participants younger than 65 years and ***:Our findings support a protective effect of moderate alcohol consumption on AAD,but are limited to participants younger than 65 years and women.

关键词： Alcohol consumption aortic aneurysm and dissection Genetic risk score Cohort study UK Biobank

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Silicate ions as soluble form of bioactive ceramics alleviate aortic aneurysm and dissection

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Bioactive Materials 2023年第7期25卷 716-731页

作者： Yumei Que Zhaowenbin Zhang Yanxin Zhang Xin Li Likai Chen Peier Chen Caiwen Ou Chen Yang Jiang Chang Joint Centre of Translational Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China Shanghai Institute of Ceramics Chinese Academy of Sciences(CAS)1295 Dingxi RoadShanghai200050China Joint Centre of Translational Medicine Wenzhou InstituteUniversity of CASWenzhouZhejiang325000China Oujiang Laboratory WenzhouZhejiang325000China Center of Materials Science and Optoelectronics Engineering University of CAS19 Yuquan RoadBeijing100049China Wenzhou Medical University WenzhouZhejiang325000China Zhujiang Hospital Southern Medical UniversityGuangzhouGuangdong510280China

aortic aneurysm and dissection(AAD)are leading causes of death in the *** studies have demonstrated that silicate ions can manipulate multiple cells,especially vascular-related *** demonstrated in this study that silicate ions as soluble form of bioactive ceramics effectively alleviated aortic aneurysm and dissection in both Ang II andβ-BAPN induced AAD *** from the single targeting therapeutic drug approaches,the bioactive ceramic derived approach attributes to the effect of bioactive silicate ions on the inhibition of the AAD progression through regulating the local vascular microenvironment of aorta systematically in a multi-functional *** in vitro experiments revealed that silicate ions did not only alleviate senescence and inflammation of the mouse aortic endothelial cells,enhance M2 polarization of mouse bone marrow-derived macrophages,and reduce apoptosis of mouse aortic smooth muscle cells,but also regulate their *** in vivo studies further confirm that silicate ions could effectively alleviate senescence,inflammation,and cell apoptosis of aortas,accomplished with reduced aortic dilation,collagen deposition,and elastin laminae *** bioactive ceramic derived therapy provides a potential new treatment strategy in attenuating AAD progression.

关键词： Silicate ions aortic aneurysm and dissection Senescence Inflammation Cell apoptosis

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