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Hailey-Hailey disease with lichenoid lesions around the anus

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Chinese Medical Journal 2019年第6期132卷 738-740页

作者： Yi-Man Wang Yue-Ping Zeng Wen-Ung Zhao Yue-Hua Liu Li Li Department of Dermatology Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China

To the Editor: Hailey-Hailey disease (HHD), first discovered by the brothers Howard and Hugh Hailey,[1]is a genodermatosis at intertriginous sites. Mutation of ATP2C1 on chromosome 3q21-2 coding a calciumdependent ATPase gives rise to calcium dysfunction within keratinocytes, resulting in acantholysis due to a signal transduction disorder.[2] It has been suggested that this gene mutation combined with irritation such as frequent friction, cold, and ultraviolet exposure leads to the development of HHD.[3]

关键词： Hailey-Hailey disease lichenoid lesions around the anus

Neurostimulation for fecal incontinence after correction of repair of imperforate anus

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World Journal of Clinical Cases 2017年第3期5卷 124-127页

作者： Alexandre Bougie Nathalie McFadden Sandeep Mayer Michel Lebel Ghislain Devroede Surgery Department Centre Hospitalier Universitaire de SherbrookeFaculté de MédecineUniversité de Sherbrooke Medicine Department NeurologyCentre Hospitalier Universitaire de SherbrookeFaculté de MédecineUniversité de Sherbrooke

We are reporting the case of a 32-year-old female who had suffered from fecal incontinence(FI). She was born with an imperforate anus and a recto-vaginal fistula; she underwent repair at 6 mo of age. At 29 years of age, she was still fecally incontinent despite extensive pelvic floor reeducation. A magnetic resonance imaging and an anal electromyography were performed. Because her symptoms were considered to be probably due to extra-sphincteric implantation of the neo-anus, a redo was performed of the recto-neo-anal intra-sphincteric anastomosis. A neurostimulator device was subsequently implanted for persistent incontinence. Solid and liquid FI resolved, and her quality of life improved markedly. Combining surgery to correct the position of the neo-anus within the anal sphincter complex and neurostimulation could thus become a new approach in cases of refractory FI for patients with imperforate anus as a newborn. Follow-up into adulthood after pediatric imperforate anus surgery should be recommended for adult patients with persistent FI.

关键词： Fecal incontinence Congenital malformation Neuromodulation Neurostimulation Imperforate anus

Long-term outcome of stem cell transplantation with and without anti-tumor necrotic factor therapy in perianal fistula with Crohn’s disease

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World Journal of Stem Cells 2024年第3期16卷 257-266页

作者： Min Young Park Yong Sik Yoon Jae Ha Park Jong Lyul Lee Chang Sik Yu Division of Colon and Rectal Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722South Korea Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND Stem cell transplantation is a promising therapeutic option for curing perianal fistula in Crohn’s disease(CD).Anti-tumor necrotic factor(TNF)therapy combined with drainage procedure is effective as ***,previous studies are limited to proving whether the combination treatment of biologics and stem cell transplantation improves the effect of fistula *** This study aimed to evaluate the long-term outcomes of stem cell transplantation and compare Crohn’s perianal fistula(CPF)closure rates after stem cell transplantation with and without anti-TNF therapy,and to identify the factors affecting CPF closure and *** The patients with CD who underwent stem cell transplantation for treating perianal fistula in our institution between Jun 2014 and December 2022 were *** data were compared according to anti-TNF therapy and CPF *** A total of 65 patients were *** median age of females was 26 years(range:21-31)and that of males was 29(44.6%).The mean follow-up duration was 65.88±32.65 months,and complete closure was observed in 50(76.9%)*** closure rates were similar after stem cell transplantation with and without anti-TNF therapy(66.7%vs 81.6%at 3 year,P=0.098).The patients with fistula closure had short fistulous tract and infrequent proctitis and anorectal stricture(P=0.027,0.002,and 0.008,respectively).Clinical factors such as complexity,number of fistulas,presence of concurrent abscess,and medication were not significant for *** cumulative 1-,2-,and 3-year closure rates were 66.2%,73.8%,and 75.4%,*** Anti-TNF therapy does not increase CPF closure rates in patients with stem cell ***,both refractory and non-refractory CPF have similar closure rates after additional anti-TNF *** tract length,proctitis,and anal stricture are risk factors for non-closure in patients with CPF after stem cell transplantation.

关键词： Crohn’s disease anus Fistula Stem cell transplantation Tumor necrosis factor-alpha inhibitors Infliximab

Education of Parents When a Child Born with an Imperforate anus;Does It Improve the Health of the Child?

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Open Journal of Pediatrics 2015年第1期5卷 90-98页

作者： Thi Hoa Chu Thi Hoa Duong National Hospital of Pediatrics Hanoi Vietnam Centre for Person-Centred Care (GPCC) Institute of Health and Care Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

Objectives: To describe and investigate the value of an education program for parents of children born with an imperforate anus in order to help them cope with the new situation of having a stoma. A comparison is made with a group of parents following routine hospital. A secondary aim was to illuminate the parents’ feelings and concerns in the first month after the birth of the child. Subjects and methods: The program was tested in 20 Vietnamese mothers of babies born with an imperforate anus;10 followed an intervention comprising an education program and 10 the ordinary routine hospital. The study design is both qualitative and quantitative. The mothers were interviewed, using open-ended questions, within a week of their child’s birth and then repeatedly for up to one month. Finally, the conditions of children were accessed on their return to the hospital for the second operation after one month of care at home. The qualitative data were subjected to content analysis. Results: All mothers felt sad and worried in the beginning, but this quickly changed to confidence, particularly among mothers in the intervention group who received education. While at home, mothers in both groups had financial concerns, as they were unable to work as much as expected and also had to buy equipment for colostomy care. The mothers in the control group complained about a lack of knowledge and how it affected the care of their child. The mothers in the intervention group, however, felt confident in their caring even at home. When the families returned for the second operation, the children in the intervention group were significantly healthier, had increased more in weight, and had fewer complications and emergency return visits to hospital compared to the control group. In the control group skin problems around the stoma, diarrhea, bleeding or constipation while at home were reported (p < 0.01). Conclusion: The education improved the care at home resulting in healthier children and more

关键词： Imperforate anus Participation Education for Parents

OBSERVATION ON THERAPEUTIC EFFECTS OF ACUPUNCTURE IN 206 CASES WITH POSTOPERATIVE COMPLICATION OF anus AND INTESTINE

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World Journal of Acupuncture-Moxibustion 1997年第1期7卷 13-17页

作者：李复明李梅

The authors have treated postoperative complication of anus and intestine by usingacupuncture at main point Chengshan(BL 57) with cool-producing needling manipulation. Therapeuticeffects of the treatment on postoperative severe pain, retention of urine, constipation, and bleedingwere observed clinically. Results indicated that the cure rate was 97. 6 % and the total effective ratewas 100%. Strong stimulation of Chengshan(BL 57) point improved mainly postoperative edema,spasm, local edema. The improvement of hyperemia and spasm is a ma jor factor of curing various postoperative complication of the anus and intestine. The therapeutic method has advantages of using lesspoints, rapidly producing effects, shorter therapeutic course, suffering little for patients, and no sideeffect.

关键词： anus Surgical operation Postoperative complication Pain Uroschesis Acupuncture therapy

Manometric asymmetry of the anal sphincter: anatomic evidence and clinical application

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Chinese Medical Journal 2005年第3期118卷 210-214页

作者： XIAOYuan-hong LIUGui-lin DepartmentofPediatricSurgery PLAGeneralHospitalBeijing100853China

Background Manometric pressure asymmetry of the anal sphincter exists in the anal canal. There are reports about the anatomy of the anal sphincter, but the relationship between the configuration and the pressure asymmetry of the anal sphincter is not clear. This study is to investigate the anatomic evidence and clinical application of anal sphincter pressure asymmetry. Methods PC polygram HR at the state of relaxing and squeezing was used in 27 normal children and 12 abnormal ones with fecal incontinence. Results In normal children, longitudinal pressure gradients existed at eight channels in the anal canal, and the maximal pressure I cm from the anal verge. Longitudinal pressure asymmetry changes of eight channels also existed in the anal canal, from 3 cm to 2 cm to I cm from the anal verge. The high pressure distribution changed from the posterior to the anterior anal canal. Anteriorly, 1 cm from the anal verge, the maximal pressure was formed in the anal canal. However, neither longitudinal pressure gradients nor longitudinal pressure asymmetry changes were seen in patients with fecal incontinence. Conclusion The configuration and function of the striated muscle complex possibly contribute to the formation of the pressure asymmetry of the anal sphincter, which is essential to anal control.

关键词： anus manometry anal sphincter pressure manometric asymmetry gradient anatomy

Anal carcinoma in giant anal condyloma, multidisciplinary approach necessary for optimal outcome:Two case reports and review of literature

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World Journal of Gastrointestinal Oncology 2019年第2期11卷 172-180页

作者： Santosh Shenoy Murali Nittala Yazen Assaf Department of General and Colorectal Surgery KCVA and University of Missouri at Kansas City

BACKGROUND Anal cancers are caused by human papilloma virus(HPV). Buschke-Lowenstein tumor also known as giant anal condyloma(GCA) is a variant of giant neglected anal tumors arising from warts caused by HPV infection. HPV are a family of double-stranded DNA viruses and primarily cause sexually transmitted disease of the genitalia and oropharyngeal mucosa. These tumors are slow growing;locally destructive large verrucous *** SUMMARY We present a series of two cases with large anal tumors harboring invasive cancers and highlight their presentation and management. Tumors with high risk HPV subtypes(HPV 16, 18, 31, 33) may progress into invasive squamous cell carcinoma(SCC). Untreated GCA can attain enormous size and extend into the pelvic organs and bony structures. Some tumors show malignant degeneration into SCC and are often difficult to diagnose given the large size of the *** surgical excision with negative margins is the treatment of choice and necessary to prevent recurrence. This is often not feasible and leaves large surgical wounds with tissue defects with delay in healing and increases postoperative morbidity. Pelvic reconstructive techniques including muscle flaps and grafts are often necessary to close the defects. Human immunodeficiency virus and immunocompromised patients generally do poorly with standard *** A multidisciplinary team of colorectal and plastic surgeons, medical and radiation oncologists along with combination treatment modalities are necessary when malignant transformation occurs in GCA, for optimal outcomes.

关键词： Squamous cell carcinoma of anus Human papilloma virus infection Giant anal condyloma Buschke-Lowenstein tumor Multidisciplinary treatment Case report

Human papillomavirus-related squamous cell carcinoma of the anal canal with papillary features

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World Journal of Gastroenterology 2015年第7期21卷 2210-2213页

作者： Marino E Leon Rania Shamekh Domenico Coppola Department of Anatomic Pathology H. Lee Moffitt Cancer Center and Research Institute Department of Pathology and Cell Biology University of South Florida

Human papillomavirus(HPV)related squamous cell carcinoma(SCC)involving the anal canal is a well-known carcinoma associated with high-risk types of *** SCC with papillary morphology(papillary SCC)has been described in the *** describe,for the first time,a case of anal HPV-related squamous carcinoma with papillary *** tumor arose from the anal *** biopsies revealed a superficially invasive SCCwith prominent papillary features and associated in situ *** tumor cells were positive for p16 and were also positive for high-risk types of HPV using chromogenic in situ *** findings are consistent with a HPV-related SCC of the anal canal with papillary *** tumor shows histologic features similar to a papillary HPV-related SCC of the *** studies are needed to characterize these lesions.

关键词： anus Squamous cell carcinoma Papillary Human papil

Neonatal colon perforation due to anorectal malformations: Can it be avoided?

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World Journal of Gastroenterology 2013年第25期19卷 3915-3917页

作者： Wei-Dong Tong Kirk A Ludwig Gastric and Colorectal Division Department of Surgery Daping Hospital Third Military Medical University Division of Colorectal Surgery Department of Surgery Medical College of Wisconsin

Anorectal malformations (ARM) are common anomalies in neonates. Diagnostic and therapeutic delays in the management of ARM may lead to colonic perforation, and even death. Physical examination of the perineum is often sufficient to diagnose ARM in neonates. Notwithstanding, delayed diagnosis of ARM has become increasingly familiar to surgeons, as evidenced by the number of recent publications on this topic in the literature. In this commentary, we discuss spontaneous colonic perforation due to delayed diagnosis of ARM in neonates, and highlight the importance of early diagnosis in assuring good outcomes with surgical management. At this point, a thorough examination of the perineum during the initial newborn assessment is mandatory, particularly in those patients presenting with abdominal signs or symptoms.

关键词： Anorectal malformation Imperforate anus Bowel perforation Colon