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PDA-BPs integrated mussel-inspired multifunctional hydrogel coating on PPENK implants for anti-tumor therapy,antibacterial infection and bone regeneration

引用

Bioactive Materials 2023年第9期27卷 546-559页

作者： Yizheng Li Chengde Liu Xitong Cheng Jinyan Wang Yue Pan Cheng Liu Shouhai Zhang Xigao Jian State Key Laboratory of Fine Chemicals Frontier Science Center for Smart MaterialsSchool of Chemical EngineeringDalian University of TechnologyDalian116024China Department of Polymer Science and Engineering Dalian University of TechnologyDalian116024China State Key Laboratory of Fine Chemicals Department of Pharmaceutical SciencesSchool of Chemical EngineeringDalian University of TechnologyDalian116024China Liaoning Province Engineering Research Centre of High-Performance Resins Dalian116024China

Currently,many cancer patients with bone defects are still threatened by tumor recurrence,postoperative bacterial infection,and massive bone loss.Many methods have been studied to endow bone implants with biocompatibility,but it is difficult to find an implant material that can simultaneously solve the problems of anticancer,antibacterial and bone promotion.Here,a multifunctional gelatin methacrylate/dopamine methacrylate adhesive hydrogel coating containing 2D black phosphorus(BP)nanoparticle protected by polydopamine(pBP)is prepared by photocrosslinking to modify the surface of poly(aryl ether nitrile ketone)containing phthalazinone(PPENK)implant.The multifunctional hydrogel coating works in conjunction with pBP,which can deliver drug through photothermal mediation and kill bacteria through photodynamic therapy at the initial phase followed by promotion of osteointegration.In this design,photothermal effect of pBP control the release of doxorubicin hydrochloride loaded via electrostatic attraction.Meanwhile,pBP can generate reactive oxygen species(ROS)to eliminate bacterial infection under 808 nm laser.In the slow degradation process,pBP not only effectively consumes excess ROS and avoid apoptosis induced by ROS in normal cells,but also degrade into PO43􀀀to promote osteogenesis.In summary,nanocomposite hydrogel coatings provide a promising strategy for treatment of cancer patients with bone defects.

关键词： Poly(aryl ether nitrile ketone) Nanocomposite hydrogel coating Black phosphorus antitumor and pdt antibacterial therapy Osteogenesis

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