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Menthol based microemulsion and gel containing tacrolimus for atopic dermatitis therapy: Enhancing the percutaneous delivery and antipruritic efficacy

Menthol based microemulsion and gel containing tacrolimus fo...

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2018年第十二届中国药物制剂大会

作者：王艺璇 Sisi Cao Kaiyue Yu Yuehong Xu School of Pharmaceutical Sciences Sun Yat-sen University

Objective: Menthol, originating from natural plant, is widely used in dermatology as antipruritic, analgesic and cooling formulations. Pruritus is an emblematical feature of atopic dermatitis（AD） that triggers scratch resulting in exacerbation of AD symptoms. In this study, menthol mixed with camphor forming eutectic was first applied in oil phase of microemulsion（ME） and ME-Gel loaded tacrolimus（FK506）, which promoted to solubilize FK506, enhance percutaneous penetration and retention of FK506, effectively contributing to AD therapy and pruritic relief. Methods: ME and ME-Gel containing tacrolimus were performed for skin permeation studies in vitro. The MTT assay certificated security of ME. The AD-like symptoms of DNCB-induced BALB/c mice were treated with ME and ME-Gel, appraised by dermatitis score, TEWL, histopathological studies, NF-?B and serum IgE expression. antipruritic efficacy was demonstrated by immunofluorescent staining of substance P. Results: ME and ME-Gel groups increased approximately 1.5-fold higher than commercial preparation group in skin retention. Blank vehicle was confirmed without cytotoxicity. Attributing to inhibition of NF-?B expression, serum IgE and substance P, topical administration of ME and ME-Gel could visibly alleviate AD symptoms. In addition, scratching frequency induced by pruritus was reduced dramatically. Conclusions: Menthol based ME and ME-Gel containing FK506 were prepared to increase the solubility of drug, enhance its permeation and retention into skin. The topical administration of ME and ME-Gel could visibly alleviate inflammation response of AD-like skin lesions in BALB/c mice. Moreover, menthol played a significant role in anti-itching and adjuvant therapy.

关键词： Tacrolimus Microemulsion Menthol Atopic dermatitis Transdermal delivery antipruritic

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Propofol with Varied Functions: A Potential Therapeutic Opportunity for Postoperative Nausea, Vomiting and Pruritus—A Narrative Review

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Open Journal of Anesthesiology 2024年第2期14卷 13-24页

作者： Thomas W. Anabah Fidelis Bayor David Z. Kolbila Terence Kunfire Dakurah Sylvanus Kampo Juventus B. Ziem Anaesthesia Unit Habana Medical Services Tamale Ghana Department of Anaesthesiology Lawra Municipal Hospital Ghana Health Service Lawra Ghana Department of Obstetrics and Gynecology School of Medicine University for Development Studies Tamale Ghana Department of Anaesthesia and Intensive Care School of Medical Sciences C. K. Tedam University of Technology and Applied Sciences Navrongo Ghana Department of Medical Microbiology School of Medical Sciences C. K. Tedam University of Technology and Applied Sciences Navrongo Ghana

Background: Despite the advances in anesthetics and non-pharmacological techniques, the prevalence of postoperative nausea and vomiting in all patients remains high. It is one of the most common distressing symptoms that cause dissatisfaction among patients after anesthesia and surgery. A sub-hypnotic dose of propofol has been shown to reduce morphine-induced postoperative nausea, vomiting, and pruritus. This review article will provide sufficient knowledge on the role of propofol in minimizing opioid-induced postoperative nausea, vomiting, and pruritus by providing detailed information on propofol antiemetic and antipruritic effects, as well as discussions based on empirically available data. Method: We conducted a narrative review of the literature published between 1990 and 2023 from a range of databases;PubMed, BioMed Central, Biosis Previews, Nature, International Pharmaceutical Abstracts, Springer-Link, and Elsevier. Discussion and Conclusion: The literatures reviewed in this study have demonstrated that propofol may have diverse therapeutic effects including antiemetic and antipruritic. The antiemetic effect of propofol may be an effective therapeutic approach for the prevention of postoperative nausea and vomiting. The literature also demonstrated that the use of propofol for sedation during surgery may as well ameliorates opioids induced postoperative pruritus, which may be beneficial to surgical patients. Also, it was demonstrated that prophylactic use of propofol may be an effective way of preventing nausea and vomiting and pruritus during opioid use.

关键词： Propofol Nausea Vomiting Antiemetic antipruritic Surgery

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Preventive effect of essential oil of Cinnamomum camphora leaves against mice allergic contact dermatitis

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Asian Journal of Traditional Medicines 2019年第3期14卷 142-146页

作者： Haizhu Xing Qian Lu Nianyun Yang Nanjing University of Chinese Medicine Nanjing 210023 China

This article was aimed to study the antiinflammatory and antipruritic effects of essential oil of camphor leaves and its possible mechanism. The chemical constituents of essential oil of camphor leaves were analyzed by GC-MS. Mice allergic contact dermatitis (ACD) models were induced 0.5% 2,4-dinitrofluorobenzene (DNFB) solution. The contents of IL-4, 5-LOX, LTB4 and LTR1 in serum and the histomorphology of mice ear cutaneous tissue were measured after induction. Pathological examination showed a large number of inflammatory cells in the model group. Inflammatory cells were not seen in essential oil high dose group. The dermis slightly thickened in the low doses of essential oil group. The contents of 5-LOX, LTB4 and LTR1 of the drug groups were significantly decreased (P 0.05). Essential oil of camphor leaves has significant antiinflammatory and antipruritic effects on ACD by inhibiting the 5-LOX-LTB4-LTR1 pathway.

关键词： Cinnamomum camphora essential oil antipruritic effect

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